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The sun protection factor (SPF) inadequately defines broad spectrum photoprotection: demonstration using skin reconstructed in vitro exposed to UVA, UVBor UV-solar simulated radiation.
Eur J Dermatol. 2003 May-Jun; 13(3):242-9.EJ

Abstract

Wavelength specific biological damage has been previously identified in human skin reconstructed in vitro. Sunburn cell and pyrimidine dimers were found after UVB exposure, and alterations of dermal fibroblasts after UVA exposure. These damages permitted us to discriminate UVB and UVA single absorbers. The present study shows that these biological effects can be obtained simultaneously by a combined UVB + UVA exposure using ultraviolet solar simulated light (UV-SSR), which represents a relevant UV source. In addition, the protection afforded by two broad spectrum sunscreen complex formulations was assessed after topical application. These two formulations displayed the same sun protection factor but different UVA protection factors determined by the persistent pigment darkening (PPD) method. Dose response experiments of UVA or UV-SSR showed that the preparation with the highest PF-UVA provided a better protection with regard to dermal damage compared to the other formulation. Using an original UVB source to obtain the UVB portion of SSR spectrum, the preparations provided the same protection. This study strikingly illustrates the fact that the photoprotection afforded by two sunscreen formulations having similar SPF values is not equal with regard to dermal damage related to photoaging.

Authors+Show Affiliations

L'Oréal Recherche, C. Zviak Centre, 90 rue du Général Roguet, 92583 Clichy, France. fbernard@recherche.loreal.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

12804982

Citation

Bernerd, Françoise, et al. "The Sun Protection Factor (SPF) Inadequately Defines Broad Spectrum Photoprotection: Demonstration Using Skin Reconstructed in Vitro Exposed to UVA, UVBor UV-solar Simulated Radiation." European Journal of Dermatology : EJD, vol. 13, no. 3, 2003, pp. 242-9.
Bernerd F, Vioux C, Lejeune F, et al. The sun protection factor (SPF) inadequately defines broad spectrum photoprotection: demonstration using skin reconstructed in vitro exposed to UVA, UVBor UV-solar simulated radiation. Eur J Dermatol. 2003;13(3):242-9.
Bernerd, F., Vioux, C., Lejeune, F., & Asselineau, D. (2003). The sun protection factor (SPF) inadequately defines broad spectrum photoprotection: demonstration using skin reconstructed in vitro exposed to UVA, UVBor UV-solar simulated radiation. European Journal of Dermatology : EJD, 13(3), 242-9.
Bernerd F, et al. The Sun Protection Factor (SPF) Inadequately Defines Broad Spectrum Photoprotection: Demonstration Using Skin Reconstructed in Vitro Exposed to UVA, UVBor UV-solar Simulated Radiation. Eur J Dermatol. 2003 May-Jun;13(3):242-9. PubMed PMID: 12804982.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The sun protection factor (SPF) inadequately defines broad spectrum photoprotection: demonstration using skin reconstructed in vitro exposed to UVA, UVBor UV-solar simulated radiation. AU - Bernerd,Françoise, AU - Vioux,Corinne, AU - Lejeune,François, AU - Asselineau,Daniel, PY - 2003/6/14/pubmed PY - 2003/10/1/medline PY - 2003/6/14/entrez SP - 242 EP - 9 JF - European journal of dermatology : EJD JO - Eur J Dermatol VL - 13 IS - 3 N2 - Wavelength specific biological damage has been previously identified in human skin reconstructed in vitro. Sunburn cell and pyrimidine dimers were found after UVB exposure, and alterations of dermal fibroblasts after UVA exposure. These damages permitted us to discriminate UVB and UVA single absorbers. The present study shows that these biological effects can be obtained simultaneously by a combined UVB + UVA exposure using ultraviolet solar simulated light (UV-SSR), which represents a relevant UV source. In addition, the protection afforded by two broad spectrum sunscreen complex formulations was assessed after topical application. These two formulations displayed the same sun protection factor but different UVA protection factors determined by the persistent pigment darkening (PPD) method. Dose response experiments of UVA or UV-SSR showed that the preparation with the highest PF-UVA provided a better protection with regard to dermal damage compared to the other formulation. Using an original UVB source to obtain the UVB portion of SSR spectrum, the preparations provided the same protection. This study strikingly illustrates the fact that the photoprotection afforded by two sunscreen formulations having similar SPF values is not equal with regard to dermal damage related to photoaging. SN - 1167-1122 UR - https://www.unboundmedicine.com/medline/citation/12804982/The_sun_protection_factor__SPF__inadequately_defines_broad_spectrum_photoprotection:_demonstration_using_skin_reconstructed_in_vitro_exposed_to_UVA_UVBor_UV_solar_simulated_radiation_ L2 - https://medlineplus.gov/sunexposure.html DB - PRIME DP - Unbound Medicine ER -