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Fasting plasma insulin modulates lipid levels and particle sizes in 2- to 3-year-old children.
Obes Res. 2003 Jun; 11(6):709-21.OR

Abstract

OBJECTIVE

Obesity and hyperinsulinemia are associated with dyslipidemia in adults and older children, but little is known about these relationships in very young children. We examined the relation of fasting insulin to lipid levels and lipid particle size in young healthy children.

RESEARCH METHODS AND PROCEDURES

Analyses were performed on data from 491 healthy 2- and 3-year old Hispanic children enrolled in a dietary study conducted in New York City, 1992-1995. Obesity measures included BMI, ponderal index, skinfold thickness, and waist circumference. Low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol particle size were measured by nuclear magnetic resonance.

RESULTS

Fasting insulin level was positively correlated with triglyceride levels (r = 0.24 for boys and r = 0.23 for girls; p < 0.001 for both) and inversely correlated with HDL-cholesterol level in boys (r = -0.20; p < 0.01). Higher fasting insulin level was also correlated with smaller mean HDL particle size in both boys (r = -0.21; p < 0.001) and girls (r = -0.14; p < 0.05) and smaller mean LDL particle size in boys (r = -0.13; p < 0.05). The associations of fasting insulin level with triglyceride and HDL-cholesterol levels and HDL and LDL particle size remained significant after multivariate regression adjustment for age, sex, and BMI or ponderal index.

DISCUSSION

Fasting insulin level is associated with relative dyslipidemia in healthy 2- and 3-year-old Hispanic children.

Authors+Show Affiliations

Division of General Medicine, Columbia University College of Physicians & Surgeons, New York, New York 10032, USA. ss35@columbia.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12805392

Citation

Shea, Steven, et al. "Fasting Plasma Insulin Modulates Lipid Levels and Particle Sizes in 2- to 3-year-old Children." Obesity Research, vol. 11, no. 6, 2003, pp. 709-21.
Shea S, Aymong E, Zybert P, et al. Fasting plasma insulin modulates lipid levels and particle sizes in 2- to 3-year-old children. Obes Res. 2003;11(6):709-21.
Shea, S., Aymong, E., Zybert, P., Berglund, L., Shamoon, H., Deckelbaum, R. J., & Basch, C. E. (2003). Fasting plasma insulin modulates lipid levels and particle sizes in 2- to 3-year-old children. Obesity Research, 11(6), 709-21.
Shea S, et al. Fasting Plasma Insulin Modulates Lipid Levels and Particle Sizes in 2- to 3-year-old Children. Obes Res. 2003;11(6):709-21. PubMed PMID: 12805392.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fasting plasma insulin modulates lipid levels and particle sizes in 2- to 3-year-old children. AU - Shea,Steven, AU - Aymong,Eve, AU - Zybert,Patricia, AU - Berglund,Lars, AU - Shamoon,Harry, AU - Deckelbaum,Richard J, AU - Basch,Charles E, PY - 2003/6/14/pubmed PY - 2004/1/17/medline PY - 2003/6/14/entrez SP - 709 EP - 21 JF - Obesity research JO - Obes Res VL - 11 IS - 6 N2 - OBJECTIVE: Obesity and hyperinsulinemia are associated with dyslipidemia in adults and older children, but little is known about these relationships in very young children. We examined the relation of fasting insulin to lipid levels and lipid particle size in young healthy children. RESEARCH METHODS AND PROCEDURES: Analyses were performed on data from 491 healthy 2- and 3-year old Hispanic children enrolled in a dietary study conducted in New York City, 1992-1995. Obesity measures included BMI, ponderal index, skinfold thickness, and waist circumference. Low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol particle size were measured by nuclear magnetic resonance. RESULTS: Fasting insulin level was positively correlated with triglyceride levels (r = 0.24 for boys and r = 0.23 for girls; p < 0.001 for both) and inversely correlated with HDL-cholesterol level in boys (r = -0.20; p < 0.01). Higher fasting insulin level was also correlated with smaller mean HDL particle size in both boys (r = -0.21; p < 0.001) and girls (r = -0.14; p < 0.05) and smaller mean LDL particle size in boys (r = -0.13; p < 0.05). The associations of fasting insulin level with triglyceride and HDL-cholesterol levels and HDL and LDL particle size remained significant after multivariate regression adjustment for age, sex, and BMI or ponderal index. DISCUSSION: Fasting insulin level is associated with relative dyslipidemia in healthy 2- and 3-year-old Hispanic children. SN - 1071-7323 UR - https://www.unboundmedicine.com/medline/citation/12805392/Fasting_plasma_insulin_modulates_lipid_levels_and_particle_sizes_in_2__to_3_year_old_children_ L2 - https://doi.org/10.1038/oby.2003.101 DB - PRIME DP - Unbound Medicine ER -