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Beneficial effects of low-dose benidipine in acute autoimmune myocarditis: suppressive effects on inflammatory cytokines and inducible nitric oxide synthase.
Circ J. 2003 Jun; 67(6):545-50.CJ

Abstract

Excessive production of nitric oxide (NO) by inducible NO synthase (iNOS) contributes to the progression of myocardial damage in myocarditis. Some dihydropyridine calcium channel blockers reportedly inhibit NO production and proinflammatory cytokines and the present study sought to clarify if a low dose of benidipine, a novel dihydropyridine calcium channel blocker, would ameliorate experimental autoimmune myocarditis (EAM). Rats with or without myocarditis were administered oral benidipine at a dose of 3 mg. kg(-1). day(-1) for 3 weeks. Low-dose benidipine did not decrease blood pressure significantly compared with the untreated group, but markedly reduced the severity of myocarditis. Myocardial interleukin-1beta (IL-1beta) expression and IL-1beta-positive cells were significantly less in rats with EAM that were treated with low-dose benidipine compared with untreated rats. Also, myocardial iNOS expression and iNOS-positive cells were markedly reduced in in the treated rats compared with the untreated group. Furthermore, myocardial NO production and nitrotyrosine expression were suppressed by the treatment in rats with EAM. The cardioprotection of low-dose benidipine may be caused by suppression of inflammatory cytokines and inhibition of NO production.

Authors+Show Affiliations

Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12808275

Citation

Yuan, Zuyi, et al. "Beneficial Effects of Low-dose Benidipine in Acute Autoimmune Myocarditis: Suppressive Effects On Inflammatory Cytokines and Inducible Nitric Oxide Synthase." Circulation Journal : Official Journal of the Japanese Circulation Society, vol. 67, no. 6, 2003, pp. 545-50.
Yuan Z, Kishimoto C, Shioji K. Beneficial effects of low-dose benidipine in acute autoimmune myocarditis: suppressive effects on inflammatory cytokines and inducible nitric oxide synthase. Circ J. 2003;67(6):545-50.
Yuan, Z., Kishimoto, C., & Shioji, K. (2003). Beneficial effects of low-dose benidipine in acute autoimmune myocarditis: suppressive effects on inflammatory cytokines and inducible nitric oxide synthase. Circulation Journal : Official Journal of the Japanese Circulation Society, 67(6), 545-50.
Yuan Z, Kishimoto C, Shioji K. Beneficial Effects of Low-dose Benidipine in Acute Autoimmune Myocarditis: Suppressive Effects On Inflammatory Cytokines and Inducible Nitric Oxide Synthase. Circ J. 2003;67(6):545-50. PubMed PMID: 12808275.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beneficial effects of low-dose benidipine in acute autoimmune myocarditis: suppressive effects on inflammatory cytokines and inducible nitric oxide synthase. AU - Yuan,Zuyi, AU - Kishimoto,Chiharu, AU - Shioji,Keisuke, PY - 2003/6/17/pubmed PY - 2004/1/24/medline PY - 2003/6/17/entrez SP - 545 EP - 50 JF - Circulation journal : official journal of the Japanese Circulation Society JO - Circ J VL - 67 IS - 6 N2 - Excessive production of nitric oxide (NO) by inducible NO synthase (iNOS) contributes to the progression of myocardial damage in myocarditis. Some dihydropyridine calcium channel blockers reportedly inhibit NO production and proinflammatory cytokines and the present study sought to clarify if a low dose of benidipine, a novel dihydropyridine calcium channel blocker, would ameliorate experimental autoimmune myocarditis (EAM). Rats with or without myocarditis were administered oral benidipine at a dose of 3 mg. kg(-1). day(-1) for 3 weeks. Low-dose benidipine did not decrease blood pressure significantly compared with the untreated group, but markedly reduced the severity of myocarditis. Myocardial interleukin-1beta (IL-1beta) expression and IL-1beta-positive cells were significantly less in rats with EAM that were treated with low-dose benidipine compared with untreated rats. Also, myocardial iNOS expression and iNOS-positive cells were markedly reduced in in the treated rats compared with the untreated group. Furthermore, myocardial NO production and nitrotyrosine expression were suppressed by the treatment in rats with EAM. The cardioprotection of low-dose benidipine may be caused by suppression of inflammatory cytokines and inhibition of NO production. SN - 1346-9843 UR - https://www.unboundmedicine.com/medline/citation/12808275/Beneficial_effects_of_low_dose_benidipine_in_acute_autoimmune_myocarditis:_suppressive_effects_on_inflammatory_cytokines_and_inducible_nitric_oxide_synthase_ L2 - https://joi.jlc.jst.go.jp/JST.JSTAGE/circj/67.545?from=PubMed DB - PRIME DP - Unbound Medicine ER -