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Cholesterol synthesis in mice is suppressed but lipofuscin formation is not affected by long-term feeding of n-3 fatty acid-enriched oils compared with lard and n-6 fatty acid-enriched oils.
Biol Pharm Bull. 2003 Jun; 26(6):766-70.BP

Abstract

Hypocholesterolemic activity of dietary polyunsaturated fatty acids is observed after relatively short-term but not long-term feedings, and their long-term feedings are suspected to accelerate aging through tissue accumulation of lipid peroxides and age pigments (lipofuscin). To define the long-term effects of fats and oils in more detail, female mice were fed a conventional basal diet supplemented with lard (Lar), high-linoleic (n-6) safflower oil (Saf), rapeseed oil (Rap), high-alpha-linolenic (n-3) perilla oil (Per), or a mixture of ethyl docosahexaenoate and soybean oil (DHA/Soy) from 17 weeks to 71 weeks of age. The DHA/Soy and Per groups had decreased serum cholesterol levels compared with the Lar and Saf groups, but the difference between the Lar and Saf groups was not significant. The 3-hydroxy-3-methyglutary-CoA (HMG-CoA) reductase activity in the liver was also significantly lower in the Per and DHA/Soy groups. However, no significant difference in lipofuscin contents in the brain and liver was observed among the 5 dietary groups, despite significant differences in peroxidizability indices of the dietary and/or tissue lipids. These results indicate that n-3 fatty acid-rich oils are hypocholesterolemic by suppressing hepatic HMG-CoA reductase activity compared with animal fats and high-linoleic (n-6) oil, but tissue lipofuscin contents are not affected by a long-term feeding of fats and oils with different degree of unsaturation in mice.

Authors+Show Affiliations

Department of Preventive Nutraceutical Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12808283

Citation

Du, Chunyan, et al. "Cholesterol Synthesis in Mice Is Suppressed but Lipofuscin Formation Is Not Affected By Long-term Feeding of N-3 Fatty Acid-enriched Oils Compared With Lard and N-6 Fatty Acid-enriched Oils." Biological & Pharmaceutical Bulletin, vol. 26, no. 6, 2003, pp. 766-70.
Du C, Sato A, Watanabe S, et al. Cholesterol synthesis in mice is suppressed but lipofuscin formation is not affected by long-term feeding of n-3 fatty acid-enriched oils compared with lard and n-6 fatty acid-enriched oils. Biol Pharm Bull. 2003;26(6):766-70.
Du, C., Sato, A., Watanabe, S., Wu, C. Z., Ikemoto, A., Ando, K., Kikugawa, K., Fujii, Y., & Okuyama, H. (2003). Cholesterol synthesis in mice is suppressed but lipofuscin formation is not affected by long-term feeding of n-3 fatty acid-enriched oils compared with lard and n-6 fatty acid-enriched oils. Biological & Pharmaceutical Bulletin, 26(6), 766-70.
Du C, et al. Cholesterol Synthesis in Mice Is Suppressed but Lipofuscin Formation Is Not Affected By Long-term Feeding of N-3 Fatty Acid-enriched Oils Compared With Lard and N-6 Fatty Acid-enriched Oils. Biol Pharm Bull. 2003;26(6):766-70. PubMed PMID: 12808283.
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TY - JOUR T1 - Cholesterol synthesis in mice is suppressed but lipofuscin formation is not affected by long-term feeding of n-3 fatty acid-enriched oils compared with lard and n-6 fatty acid-enriched oils. AU - Du,Chunyan, AU - Sato,Akira, AU - Watanabe,Shiro, AU - Wu,Chun-Zheng, AU - Ikemoto,Atsushi, AU - Ando,Ken, AU - Kikugawa,Kiyomi, AU - Fujii,Yoichi, AU - Okuyama,Harumi, PY - 2003/6/17/pubmed PY - 2004/1/16/medline PY - 2003/6/17/entrez SP - 766 EP - 70 JF - Biological & pharmaceutical bulletin JO - Biol Pharm Bull VL - 26 IS - 6 N2 - Hypocholesterolemic activity of dietary polyunsaturated fatty acids is observed after relatively short-term but not long-term feedings, and their long-term feedings are suspected to accelerate aging through tissue accumulation of lipid peroxides and age pigments (lipofuscin). To define the long-term effects of fats and oils in more detail, female mice were fed a conventional basal diet supplemented with lard (Lar), high-linoleic (n-6) safflower oil (Saf), rapeseed oil (Rap), high-alpha-linolenic (n-3) perilla oil (Per), or a mixture of ethyl docosahexaenoate and soybean oil (DHA/Soy) from 17 weeks to 71 weeks of age. The DHA/Soy and Per groups had decreased serum cholesterol levels compared with the Lar and Saf groups, but the difference between the Lar and Saf groups was not significant. The 3-hydroxy-3-methyglutary-CoA (HMG-CoA) reductase activity in the liver was also significantly lower in the Per and DHA/Soy groups. However, no significant difference in lipofuscin contents in the brain and liver was observed among the 5 dietary groups, despite significant differences in peroxidizability indices of the dietary and/or tissue lipids. These results indicate that n-3 fatty acid-rich oils are hypocholesterolemic by suppressing hepatic HMG-CoA reductase activity compared with animal fats and high-linoleic (n-6) oil, but tissue lipofuscin contents are not affected by a long-term feeding of fats and oils with different degree of unsaturation in mice. SN - 0918-6158 UR - https://www.unboundmedicine.com/medline/citation/12808283/Cholesterol_synthesis_in_mice_is_suppressed_but_lipofuscin_formation_is_not_affected_by_long_term_feeding_of_n_3_fatty_acid_enriched_oils_compared_with_lard_and_n_6_fatty_acid_enriched_oils_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/bpb/26.766?from=PubMed DB - PRIME DP - Unbound Medicine ER -