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Cholesterol synthesis in mice is suppressed but lipofuscin formation is not affected by long-term feeding of n-3 fatty acid-enriched oils compared with lard and n-6 fatty acid-enriched oils.
Biol Pharm Bull. 2003 Jun; 26(6):766-70.BP

Abstract

Hypocholesterolemic activity of dietary polyunsaturated fatty acids is observed after relatively short-term but not long-term feedings, and their long-term feedings are suspected to accelerate aging through tissue accumulation of lipid peroxides and age pigments (lipofuscin). To define the long-term effects of fats and oils in more detail, female mice were fed a conventional basal diet supplemented with lard (Lar), high-linoleic (n-6) safflower oil (Saf), rapeseed oil (Rap), high-alpha-linolenic (n-3) perilla oil (Per), or a mixture of ethyl docosahexaenoate and soybean oil (DHA/Soy) from 17 weeks to 71 weeks of age. The DHA/Soy and Per groups had decreased serum cholesterol levels compared with the Lar and Saf groups, but the difference between the Lar and Saf groups was not significant. The 3-hydroxy-3-methyglutary-CoA (HMG-CoA) reductase activity in the liver was also significantly lower in the Per and DHA/Soy groups. However, no significant difference in lipofuscin contents in the brain and liver was observed among the 5 dietary groups, despite significant differences in peroxidizability indices of the dietary and/or tissue lipids. These results indicate that n-3 fatty acid-rich oils are hypocholesterolemic by suppressing hepatic HMG-CoA reductase activity compared with animal fats and high-linoleic (n-6) oil, but tissue lipofuscin contents are not affected by a long-term feeding of fats and oils with different degree of unsaturation in mice.

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Authors+Show Affiliations

Du C
Department of Preventive Nutraceutical Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan.
Sato A
No affiliation info available
Watanabe S
No affiliation info available
Wu CZ
No affiliation info available
Ikemoto A
No affiliation info available
Ando K
No affiliation info available
Kikugawa K
No affiliation info available
Fujii Y
No affiliation info available
Okuyama H
No affiliation info available

MeSH

Acyl Coenzyme AAgingAnimalsBrainCholesterolDietary FatsDietary Fats, UnsaturatedFatty Acids, MonounsaturatedFatty Acids, Omega-3Fatty Acids, Omega-6FemaleLipofuscinLiverMiceMice, Inbred C57BLPlant OilsRapeseed OilSafflower OilSoybean OilTime Factors

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12808283

Citation

Du, Chunyan, et al. "Cholesterol Synthesis in Mice Is Suppressed but Lipofuscin Formation Is Not Affected By Long-term Feeding of N-3 Fatty Acid-enriched Oils Compared With Lard and N-6 Fatty Acid-enriched Oils." Biological & Pharmaceutical Bulletin, vol. 26, no. 6, 2003, pp. 766-70.
Du C, Sato A, Watanabe S, et al. Cholesterol synthesis in mice is suppressed but lipofuscin formation is not affected by long-term feeding of n-3 fatty acid-enriched oils compared with lard and n-6 fatty acid-enriched oils. Biol Pharm Bull. 2003;26(6):766-70.
Du, C., Sato, A., Watanabe, S., Wu, C. Z., Ikemoto, A., Ando, K., Kikugawa, K., Fujii, Y., & Okuyama, H. (2003). Cholesterol synthesis in mice is suppressed but lipofuscin formation is not affected by long-term feeding of n-3 fatty acid-enriched oils compared with lard and n-6 fatty acid-enriched oils. Biological & Pharmaceutical Bulletin, 26(6), 766-70.
Du C, et al. Cholesterol Synthesis in Mice Is Suppressed but Lipofuscin Formation Is Not Affected By Long-term Feeding of N-3 Fatty Acid-enriched Oils Compared With Lard and N-6 Fatty Acid-enriched Oils. Biol Pharm Bull. 2003;26(6):766-70. PubMed PMID: 12808283.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cholesterol synthesis in mice is suppressed but lipofuscin formation is not affected by long-term feeding of n-3 fatty acid-enriched oils compared with lard and n-6 fatty acid-enriched oils. AU - Du,Chunyan, AU - Sato,Akira, AU - Watanabe,Shiro, AU - Wu,Chun-Zheng, AU - Ikemoto,Atsushi, AU - Ando,Ken, AU - Kikugawa,Kiyomi, AU - Fujii,Yoichi, AU - Okuyama,Harumi, PY - 2003/6/17/pubmed PY - 2004/1/16/medline PY - 2003/6/17/entrez SP - 766 EP - 70 JF - Biological & pharmaceutical bulletin JO - Biol Pharm Bull VL - 26 IS - 6 N2 - Hypocholesterolemic activity of dietary polyunsaturated fatty acids is observed after relatively short-term but not long-term feedings, and their long-term feedings are suspected to accelerate aging through tissue accumulation of lipid peroxides and age pigments (lipofuscin). To define the long-term effects of fats and oils in more detail, female mice were fed a conventional basal diet supplemented with lard (Lar), high-linoleic (n-6) safflower oil (Saf), rapeseed oil (Rap), high-alpha-linolenic (n-3) perilla oil (Per), or a mixture of ethyl docosahexaenoate and soybean oil (DHA/Soy) from 17 weeks to 71 weeks of age. The DHA/Soy and Per groups had decreased serum cholesterol levels compared with the Lar and Saf groups, but the difference between the Lar and Saf groups was not significant. The 3-hydroxy-3-methyglutary-CoA (HMG-CoA) reductase activity in the liver was also significantly lower in the Per and DHA/Soy groups. However, no significant difference in lipofuscin contents in the brain and liver was observed among the 5 dietary groups, despite significant differences in peroxidizability indices of the dietary and/or tissue lipids. These results indicate that n-3 fatty acid-rich oils are hypocholesterolemic by suppressing hepatic HMG-CoA reductase activity compared with animal fats and high-linoleic (n-6) oil, but tissue lipofuscin contents are not affected by a long-term feeding of fats and oils with different degree of unsaturation in mice. SN - 0918-6158 UR - https://www.unboundmedicine.com/medline/citation/12808283/Cholesterol_synthesis_in_mice_is_suppressed_but_lipofuscin_formation_is_not_affected_by_long_term_feeding_of_n_3_fatty_acid_enriched_oils_compared_with_lard_and_n_6_fatty_acid_enriched_oils_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/bpb/26.766?from=PubMed DB - PRIME DP - Unbound Medicine ER -