Tags

Type your tag names separated by a space and hit enter

Bioactivity of secoiridoid glycosides from Centaurium erythraea.
Phytomedicine. 2003 May; 10(4):344-7.P

Abstract

As part of our on-going search for bioactive compounds from Scottish plants, two secoiridoid glycosides, swertiamarin and sweroside, have been isolated from the aerial parts of Centaurium erythraea Rafn (Family: Gentianaceae) by reversed-phase preparative HPLC coupled with a photo-diode-array detector. The structures of these compounds were elucidated unambiguously by UV, FABMS and extensive 1D and 2D NMR spectroscopic analyses and also by comparing experimental data with literature data. Antibacterial, free radical scavenging activities and general toxicity of these glycosides have been assessed. Both compounds inhibited the growth of Bacillus cereus, Bacillus subtilis, Citrobacter freundii and Escherichia coli. While swertiamarin was also active against Proteus mirabilis and Serratia marcescens, sweroside inhibited the growth of Staphylococcus epidermidis. Swertiamarin and sweroside exhibited significant general toxicity in brine shrimp lethality bioassay and the LD50 values were 8.0 microg/ml and 34 microg/ml, respectively, whereas that of the positive control podophyllotoxin, a well known cytotoxic lignan, was 2.79 microg/ml. Chemotaxonomic implications of these compounds in the family Gentianaceae have also been discussed briefly.

Authors+Show Affiliations

Kumarasamy Y
Phytopharmaceutical Research Laboratory, School of Pharmacy, The Robert Gordon University, Schoolhill, Aberdeen, UK.
Nahar L
No affiliation info available
Cox PJ
No affiliation info available
Jaspars M
No affiliation info available
Sarker SD
No affiliation info available

MeSH

AnimalsAnti-Bacterial AgentsArtemiaCentauriumChromatography, High Pressure LiquidGlucosidesGram-Negative BacteriaGram-Positive BacteriaHumansIridoid GlucosidesIridoidsLethal Dose 50Magnetic Resonance SpectroscopyMicrobial Sensitivity TestsPhytotherapyPlant ExtractsPyrones

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12809366

Citation

Kumarasamy, Y, et al. "Bioactivity of Secoiridoid Glycosides From Centaurium Erythraea." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 10, no. 4, 2003, pp. 344-7.
Kumarasamy Y, Nahar L, Cox PJ, et al. Bioactivity of secoiridoid glycosides from Centaurium erythraea. Phytomedicine. 2003;10(4):344-7.
Kumarasamy, Y., Nahar, L., Cox, P. J., Jaspars, M., & Sarker, S. D. (2003). Bioactivity of secoiridoid glycosides from Centaurium erythraea. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 10(4), 344-7.
Kumarasamy Y, et al. Bioactivity of Secoiridoid Glycosides From Centaurium Erythraea. Phytomedicine. 2003;10(4):344-7. PubMed PMID: 12809366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioactivity of secoiridoid glycosides from Centaurium erythraea. AU - Kumarasamy,Y, AU - Nahar,L, AU - Cox,P J, AU - Jaspars,M, AU - Sarker,S D, PY - 2003/6/18/pubmed PY - 2003/8/26/medline PY - 2003/6/18/entrez SP - 344 EP - 7 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 10 IS - 4 N2 - As part of our on-going search for bioactive compounds from Scottish plants, two secoiridoid glycosides, swertiamarin and sweroside, have been isolated from the aerial parts of Centaurium erythraea Rafn (Family: Gentianaceae) by reversed-phase preparative HPLC coupled with a photo-diode-array detector. The structures of these compounds were elucidated unambiguously by UV, FABMS and extensive 1D and 2D NMR spectroscopic analyses and also by comparing experimental data with literature data. Antibacterial, free radical scavenging activities and general toxicity of these glycosides have been assessed. Both compounds inhibited the growth of Bacillus cereus, Bacillus subtilis, Citrobacter freundii and Escherichia coli. While swertiamarin was also active against Proteus mirabilis and Serratia marcescens, sweroside inhibited the growth of Staphylococcus epidermidis. Swertiamarin and sweroside exhibited significant general toxicity in brine shrimp lethality bioassay and the LD50 values were 8.0 microg/ml and 34 microg/ml, respectively, whereas that of the positive control podophyllotoxin, a well known cytotoxic lignan, was 2.79 microg/ml. Chemotaxonomic implications of these compounds in the family Gentianaceae have also been discussed briefly. SN - 0944-7113 UR - https://www.unboundmedicine.com/medline/citation/12809366/Bioactivity_of_secoiridoid_glycosides_from_Centaurium_erythraea_ DB - PRIME DP - Unbound Medicine ER -