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Gallstones, gallbladder disease, and pancreatitis: cross-sectional and 2-year data from the Swedish Obese Subjects (SOS) and SOS reference studies.
Am J Gastroenterol 2003; 98(5):1032-41AJ

Abstract

OBJECTIVES

Obesity and weight loss have been associated with gallstone disease. There is also an association between gallstones and pancreatitis. We investigated cross-sectional relationships between body mass index (BMI), body fat distribution, and prevalence of gallstones, gallbladder disease, and pancreatitis in men and women. Furthermore, 2-yr incidences of these disorders were examined in relation to changes in weight and body fat distribution after surgical and conventional obesity treatment.

METHODS

Self-administered questionnaires were used to assess biliary and pancreatic disease. In the cross-sectional investigation, 6328 obese patients and 1135 randomly selected reference individuals were used. Longitudinally, 1422 operated and 1260 conventionally treated patients were examined.

RESULTS

Obese subjects had significantly higher prevalence of cholelithiasis, cholecystitis, cholecystectomies, and pancreatitis as compared with the reference population. In women, BMI and waist-hip ratio (WHR) were independently related to an increased biliary disease prevalence. In men, only BMI was independently associated with biliary disease. Compared with conventional treatment, obesity surgery significantly increased the incidence of cholelithiasis, cholecystitis, and cholecystectomies in men. There was no incidence difference among women. In both genders, weight loss, but not change in WHR, was related to an increased incidence of biliary disease.

CONCLUSIONS

This study showed an increased prevalence of gallstones, gallbladder disease, and pancreatitis in the obese. Biliary disease was related to BMI and WHR in women, but only to BMI in men. Weight loss, but not change in WHR, increased the risk of biliary disease in both genders.

Authors+Show Affiliations

Swedish Obese Subjects Secretariat, Department of Body Composition and Metabolism, Sahlgrenska University Hospital, Göteborg, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12809825

Citation

Torgerson, Jarl S., et al. "Gallstones, Gallbladder Disease, and Pancreatitis: Cross-sectional and 2-year Data From the Swedish Obese Subjects (SOS) and SOS Reference Studies." The American Journal of Gastroenterology, vol. 98, no. 5, 2003, pp. 1032-41.
Torgerson JS, Lindroos AK, Näslund I, et al. Gallstones, gallbladder disease, and pancreatitis: cross-sectional and 2-year data from the Swedish Obese Subjects (SOS) and SOS reference studies. Am J Gastroenterol. 2003;98(5):1032-41.
Torgerson, J. S., Lindroos, A. K., Näslund, I., & Peltonen, M. (2003). Gallstones, gallbladder disease, and pancreatitis: cross-sectional and 2-year data from the Swedish Obese Subjects (SOS) and SOS reference studies. The American Journal of Gastroenterology, 98(5), pp. 1032-41.
Torgerson JS, et al. Gallstones, Gallbladder Disease, and Pancreatitis: Cross-sectional and 2-year Data From the Swedish Obese Subjects (SOS) and SOS Reference Studies. Am J Gastroenterol. 2003;98(5):1032-41. PubMed PMID: 12809825.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gallstones, gallbladder disease, and pancreatitis: cross-sectional and 2-year data from the Swedish Obese Subjects (SOS) and SOS reference studies. AU - Torgerson,Jarl S, AU - Lindroos,Anna Karin, AU - Näslund,Ingmar, AU - Peltonen,Markku, PY - 2003/6/18/pubmed PY - 2003/7/25/medline PY - 2003/6/18/entrez SP - 1032 EP - 41 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 98 IS - 5 N2 - OBJECTIVES: Obesity and weight loss have been associated with gallstone disease. There is also an association between gallstones and pancreatitis. We investigated cross-sectional relationships between body mass index (BMI), body fat distribution, and prevalence of gallstones, gallbladder disease, and pancreatitis in men and women. Furthermore, 2-yr incidences of these disorders were examined in relation to changes in weight and body fat distribution after surgical and conventional obesity treatment. METHODS: Self-administered questionnaires were used to assess biliary and pancreatic disease. In the cross-sectional investigation, 6328 obese patients and 1135 randomly selected reference individuals were used. Longitudinally, 1422 operated and 1260 conventionally treated patients were examined. RESULTS: Obese subjects had significantly higher prevalence of cholelithiasis, cholecystitis, cholecystectomies, and pancreatitis as compared with the reference population. In women, BMI and waist-hip ratio (WHR) were independently related to an increased biliary disease prevalence. In men, only BMI was independently associated with biliary disease. Compared with conventional treatment, obesity surgery significantly increased the incidence of cholelithiasis, cholecystitis, and cholecystectomies in men. There was no incidence difference among women. In both genders, weight loss, but not change in WHR, was related to an increased incidence of biliary disease. CONCLUSIONS: This study showed an increased prevalence of gallstones, gallbladder disease, and pancreatitis in the obese. Biliary disease was related to BMI and WHR in women, but only to BMI in men. Weight loss, but not change in WHR, increased the risk of biliary disease in both genders. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/12809825/Gallstones_gallbladder_disease_and_pancreatitis:_cross_sectional_and_2_year_data_from_the_Swedish_Obese_Subjects__SOS__and_SOS_reference_studies_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0002-9270&date=2003&volume=98&issue=5&spage=1032 DB - PRIME DP - Unbound Medicine ER -