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308-nm excimer laser for the treatment of psoriasis: induration-based dosimetry.
Arch Dermatol 2003; 139(6):759-64AD

Abstract

OBJECTIVE

To determine the response of stubborn psoriatic plaques to the 308-nm excimer laser.

DESIGN

Controlled study with a before-after design.

SETTING

A university-based clinical research center.

PATIENTS

Adult subjects with recalcitrant plaque psoriasis that have not responded to other therapies for at least 2 months.

INTERVENTIONS

Selected psoriatic plaques were treated with the 308-nm excimer laser. One lesion was left as a control. Each plaque was treated 2 times a week, with an initial dose based solely on the induration component of the modified Psoriasis Area and Severity Index score for that lesion. Subsequent treatments were twice a week with dosage increments up to 50%, based on the change in induration. Four final consolidation doses were given once the induration score was reduced to zero.

RESULTS

Eighteen subjects were treated. There were 4 dropouts because of various scheduling problems. In the remaining 14 subjects, 44 plaques received a mean of 10 treatments (range, 4-14). Treatments were quick and well tolerated. The mean cumulative dose was 8.8 J/cm2 (range, 2.2-22.8 J/cm2). Compared with controls, treated plaques showed significant improvement (P<.001). The only adverse event was a mild sunburn-like reaction in 2 subjects after 1 treatment.

CONCLUSIONS

Selective targeting of laser-generated 308-nm excimer radiation with this convenient subblistering dosage schedule based on induration allows for individualized treatment plans for each plaque. Clearing of stubborn psoriatic lesions occurs rapidly and safely.

Authors+Show Affiliations

Gange Photomedicine Research Center, Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA.

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12810507

Citation

Taneja, Atul, et al. "308-nm Excimer Laser for the Treatment of Psoriasis: Induration-based Dosimetry." Archives of Dermatology, vol. 139, no. 6, 2003, pp. 759-64.
Taneja A, Trehan M, Taylor CR. 308-nm excimer laser for the treatment of psoriasis: induration-based dosimetry. Arch Dermatol. 2003;139(6):759-64.
Taneja, A., Trehan, M., & Taylor, C. R. (2003). 308-nm excimer laser for the treatment of psoriasis: induration-based dosimetry. Archives of Dermatology, 139(6), pp. 759-64.
Taneja A, Trehan M, Taylor CR. 308-nm Excimer Laser for the Treatment of Psoriasis: Induration-based Dosimetry. Arch Dermatol. 2003;139(6):759-64. PubMed PMID: 12810507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 308-nm excimer laser for the treatment of psoriasis: induration-based dosimetry. AU - Taneja,Atul, AU - Trehan,Manju, AU - Taylor,Charles R, PY - 2003/6/18/pubmed PY - 2003/7/3/medline PY - 2003/6/18/entrez SP - 759 EP - 64 JF - Archives of dermatology JO - Arch Dermatol VL - 139 IS - 6 N2 - OBJECTIVE: To determine the response of stubborn psoriatic plaques to the 308-nm excimer laser. DESIGN: Controlled study with a before-after design. SETTING: A university-based clinical research center. PATIENTS: Adult subjects with recalcitrant plaque psoriasis that have not responded to other therapies for at least 2 months. INTERVENTIONS: Selected psoriatic plaques were treated with the 308-nm excimer laser. One lesion was left as a control. Each plaque was treated 2 times a week, with an initial dose based solely on the induration component of the modified Psoriasis Area and Severity Index score for that lesion. Subsequent treatments were twice a week with dosage increments up to 50%, based on the change in induration. Four final consolidation doses were given once the induration score was reduced to zero. RESULTS: Eighteen subjects were treated. There were 4 dropouts because of various scheduling problems. In the remaining 14 subjects, 44 plaques received a mean of 10 treatments (range, 4-14). Treatments were quick and well tolerated. The mean cumulative dose was 8.8 J/cm2 (range, 2.2-22.8 J/cm2). Compared with controls, treated plaques showed significant improvement (P<.001). The only adverse event was a mild sunburn-like reaction in 2 subjects after 1 treatment. CONCLUSIONS: Selective targeting of laser-generated 308-nm excimer radiation with this convenient subblistering dosage schedule based on induration allows for individualized treatment plans for each plaque. Clearing of stubborn psoriatic lesions occurs rapidly and safely. SN - 0003-987X UR - https://www.unboundmedicine.com/medline/citation/12810507/308_nm_excimer_laser_for_the_treatment_of_psoriasis:_induration_based_dosimetry_ L2 - https://jamanetwork.com/journals/jamadermatology/fullarticle/vol/139/pg/759 DB - PRIME DP - Unbound Medicine ER -