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308-nm excimer laser for the treatment of psoriasis: induration-based dosimetry.
Arch Dermatol. 2003 Jun; 139(6):759-64.AD

Abstract

OBJECTIVE

To determine the response of stubborn psoriatic plaques to the 308-nm excimer laser.

DESIGN

Controlled study with a before-after design.

SETTING

A university-based clinical research center.

PATIENTS

Adult subjects with recalcitrant plaque psoriasis that have not responded to other therapies for at least 2 months.

INTERVENTIONS

Selected psoriatic plaques were treated with the 308-nm excimer laser. One lesion was left as a control. Each plaque was treated 2 times a week, with an initial dose based solely on the induration component of the modified Psoriasis Area and Severity Index score for that lesion. Subsequent treatments were twice a week with dosage increments up to 50%, based on the change in induration. Four final consolidation doses were given once the induration score was reduced to zero.

RESULTS

Eighteen subjects were treated. There were 4 dropouts because of various scheduling problems. In the remaining 14 subjects, 44 plaques received a mean of 10 treatments (range, 4-14). Treatments were quick and well tolerated. The mean cumulative dose was 8.8 J/cm2 (range, 2.2-22.8 J/cm2). Compared with controls, treated plaques showed significant improvement (P<.001). The only adverse event was a mild sunburn-like reaction in 2 subjects after 1 treatment.

CONCLUSIONS

Selective targeting of laser-generated 308-nm excimer radiation with this convenient subblistering dosage schedule based on induration allows for individualized treatment plans for each plaque. Clearing of stubborn psoriatic lesions occurs rapidly and safely.

Authors+Show Affiliations

Gange Photomedicine Research Center, Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12810507

Citation

Taneja, Atul, et al. "308-nm Excimer Laser for the Treatment of Psoriasis: Induration-based Dosimetry." Archives of Dermatology, vol. 139, no. 6, 2003, pp. 759-64.
Taneja A, Trehan M, Taylor CR. 308-nm excimer laser for the treatment of psoriasis: induration-based dosimetry. Arch Dermatol. 2003;139(6):759-64.
Taneja, A., Trehan, M., & Taylor, C. R. (2003). 308-nm excimer laser for the treatment of psoriasis: induration-based dosimetry. Archives of Dermatology, 139(6), 759-64.
Taneja A, Trehan M, Taylor CR. 308-nm Excimer Laser for the Treatment of Psoriasis: Induration-based Dosimetry. Arch Dermatol. 2003;139(6):759-64. PubMed PMID: 12810507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 308-nm excimer laser for the treatment of psoriasis: induration-based dosimetry. AU - Taneja,Atul, AU - Trehan,Manju, AU - Taylor,Charles R, PY - 2003/6/18/pubmed PY - 2003/7/3/medline PY - 2003/6/18/entrez SP - 759 EP - 64 JF - Archives of dermatology JO - Arch Dermatol VL - 139 IS - 6 N2 - OBJECTIVE: To determine the response of stubborn psoriatic plaques to the 308-nm excimer laser. DESIGN: Controlled study with a before-after design. SETTING: A university-based clinical research center. PATIENTS: Adult subjects with recalcitrant plaque psoriasis that have not responded to other therapies for at least 2 months. INTERVENTIONS: Selected psoriatic plaques were treated with the 308-nm excimer laser. One lesion was left as a control. Each plaque was treated 2 times a week, with an initial dose based solely on the induration component of the modified Psoriasis Area and Severity Index score for that lesion. Subsequent treatments were twice a week with dosage increments up to 50%, based on the change in induration. Four final consolidation doses were given once the induration score was reduced to zero. RESULTS: Eighteen subjects were treated. There were 4 dropouts because of various scheduling problems. In the remaining 14 subjects, 44 plaques received a mean of 10 treatments (range, 4-14). Treatments were quick and well tolerated. The mean cumulative dose was 8.8 J/cm2 (range, 2.2-22.8 J/cm2). Compared with controls, treated plaques showed significant improvement (P<.001). The only adverse event was a mild sunburn-like reaction in 2 subjects after 1 treatment. CONCLUSIONS: Selective targeting of laser-generated 308-nm excimer radiation with this convenient subblistering dosage schedule based on induration allows for individualized treatment plans for each plaque. Clearing of stubborn psoriatic lesions occurs rapidly and safely. SN - 0003-987X UR - https://www.unboundmedicine.com/medline/citation/12810507/308_nm_excimer_laser_for_the_treatment_of_psoriasis:_induration_based_dosimetry_ L2 - https://jamanetwork.com/journals/jamadermatology/fullarticle/vol/139/pg/759 DB - PRIME DP - Unbound Medicine ER -