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Vitamin D and the skin.

Abstract

Vitamin D was originally discovered as a factor that regulates calcium and bone metabolism. Recent advances in investigation have shown that vitamin D also functions as a regulator of cellular growth and differentiation in various tissues. The skin is not an exception from such effects of vitamin D; it is regarded as a site of its activation and action. Evidence has accumulated showing that the active form of vitamin D and its analogs suppress growth and stimulate the terminal differentiation of keratinocytes. In psoriatic lesions, epidermal keratinocytes exhibit hyper-proliferation and impaired differentiation triggered by inflammation. Therefore, it is quite reasonable that vitamin D is effective on psoriasis. Indeed, within the past decade, analogs of vitamin D3 have been used as topical therapy for psoriasis. In this review, we summarize the fundamental features of vitamin D and the development of vitamin D therapy for psoriasis. Clinical application to other skin diseases and the future of vitamin D therapy in dermatology are also discussed.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Dermatology, Course of Molecular Medicine, Graduate School of Medicine, Osaka University, Suita, Japan.

    ,

    Source

    The Journal of dermatology 30:6 2003 Jun pg 429-37

    MeSH

    Forecasting
    Humans
    Psoriasis
    Skin
    Skin Aging
    Vitamin D

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    12810989

    Citation

    Kira, Masahiro, et al. "Vitamin D and the Skin." The Journal of Dermatology, vol. 30, no. 6, 2003, pp. 429-37.
    Kira M, Kobayashi T, Yoshikawa K. Vitamin D and the skin. J Dermatol. 2003;30(6):429-37.
    Kira, M., Kobayashi, T., & Yoshikawa, K. (2003). Vitamin D and the skin. The Journal of Dermatology, 30(6), pp. 429-37.
    Kira M, Kobayashi T, Yoshikawa K. Vitamin D and the Skin. J Dermatol. 2003;30(6):429-37. PubMed PMID: 12810989.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamin D and the skin. AU - Kira,Masahiro, AU - Kobayashi,Teruaki, AU - Yoshikawa,Kunihiko, PY - 2003/02/19/received PY - 2003/02/27/accepted PY - 2003/6/18/pubmed PY - 2004/1/14/medline PY - 2003/6/18/entrez SP - 429 EP - 37 JF - The Journal of dermatology JO - J. Dermatol. VL - 30 IS - 6 N2 - Vitamin D was originally discovered as a factor that regulates calcium and bone metabolism. Recent advances in investigation have shown that vitamin D also functions as a regulator of cellular growth and differentiation in various tissues. The skin is not an exception from such effects of vitamin D; it is regarded as a site of its activation and action. Evidence has accumulated showing that the active form of vitamin D and its analogs suppress growth and stimulate the terminal differentiation of keratinocytes. In psoriatic lesions, epidermal keratinocytes exhibit hyper-proliferation and impaired differentiation triggered by inflammation. Therefore, it is quite reasonable that vitamin D is effective on psoriasis. Indeed, within the past decade, analogs of vitamin D3 have been used as topical therapy for psoriasis. In this review, we summarize the fundamental features of vitamin D and the development of vitamin D therapy for psoriasis. Clinical application to other skin diseases and the future of vitamin D therapy in dermatology are also discussed. SN - 0385-2407 UR - https://www.unboundmedicine.com/medline/citation/12810989/Vitamin_D_and_the_skin_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0385-2407&date=2003&volume=30&issue=6&spage=429 DB - PRIME DP - Unbound Medicine ER -