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Current chemotherapy of human African trypanosomiasis.
Parasitol Res. 2003 Jun; 90 Supp 1:S10-3.PR

Abstract

Human African trypanosomiasis is a fatal disease caused by Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense that has re-emerged in recent years. However, very little progress has been made in the development of new drugs against this disease. Most drugs still in use were developed one or more decades ago, and are generally toxic and of limited effectiveness. The most recently introduced compound, eflornithine, is only useful against sleeping sickness caused by T. b. gambiense, and is prohibitively expensive for the African developing countries. We present here an overview of today's approved and clinically used drugs against this disease.

Authors+Show Affiliations

Docampo R
Laboratory of Molecular Parasitology, Department of Pathobiology, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, IL 61802, USA. rodoc@uiuc.edu
Moreno SN
No affiliation info available

MeSH

AnimalsEflornithineHumansMelarsoprolPentamidineSuraminTrypanocidal AgentsTrypanosomaTrypanosomiasis, African

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

12811544

Citation

Docampo, Roberto, and Silvia N J. Moreno. "Current Chemotherapy of Human African Trypanosomiasis." Parasitology Research, vol. 90 Supp 1, 2003, pp. S10-3.
Docampo R, Moreno SN. Current chemotherapy of human African trypanosomiasis. Parasitol Res. 2003;90 Supp 1:S10-3.
Docampo, R., & Moreno, S. N. (2003). Current chemotherapy of human African trypanosomiasis. Parasitology Research, 90 Supp 1, S10-3.
Docampo R, Moreno SN. Current Chemotherapy of Human African Trypanosomiasis. Parasitol Res. 2003;90 Supp 1:S10-3. PubMed PMID: 12811544.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Current chemotherapy of human African trypanosomiasis. AU - Docampo,Roberto, AU - Moreno,Silvia N J, Y1 - 2002/11/23/ PY - 2003/6/18/pubmed PY - 2003/8/9/medline PY - 2003/6/18/entrez SP - S10 EP - 3 JF - Parasitology research JO - Parasitol Res VL - 90 Supp 1 N2 - Human African trypanosomiasis is a fatal disease caused by Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense that has re-emerged in recent years. However, very little progress has been made in the development of new drugs against this disease. Most drugs still in use were developed one or more decades ago, and are generally toxic and of limited effectiveness. The most recently introduced compound, eflornithine, is only useful against sleeping sickness caused by T. b. gambiense, and is prohibitively expensive for the African developing countries. We present here an overview of today's approved and clinically used drugs against this disease. SN - 0932-0113 UR - https://www.unboundmedicine.com/medline/citation/12811544/Current_chemotherapy_of_human_African_trypanosomiasis_ DB - PRIME DP - Unbound Medicine ER -