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Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene.
Oncogene. 2003 Jun 19; 22(25):3911-6.O

Abstract

Integration of Hepatitis B Virus (HBV) DNA into liver cell DNA has been well established, but its implication in liver carcinogenesis is still being debated. In particular, insertion of the viral genome into cellular genes has been viewed as a rare event. By using HBV-Alu PCR, we have now isolated, from nine hepatocellular carcinomas, nine HBV-DNA integration sites showing that the viral genome mutates key regulatory cellular genes: neurotropic tyrosin receptor kinase 2 (NTRK2) gene, IL-1R-associated kinase 2 (IRAK2) gene, p42 mitogen-activated protein kinase 1 (p42MAPK1) gene, inositol 1,4,5-triphosphate receptor type 2 (IP3R2) gene, inositol 1,4,5-triphosphate receptor (IP3R) type 1 (IP3R1) gene, alpha 2,3 sialyltransferase (ST3GAL VI or SITA) gene, thyroid hormone uncoupling protein (TRUP) gene, EMX2-like gene, and human telomerase reverse transcriptase (hTERT) gene. This result brings to 15 the total number of genes targeted by HBV in a study of 22 human liver cancers. Overall, we found that both the inositol 1,4,5-triphosphate receptor gene and the telomerase gene were targeted by HBV in two different tumors. Thus, HBV frequently targets cellular genes involved in cell signalling and some of them may be preferential targets of the viral integration.

Authors+Show Affiliations

INSERM/Pasteur Unit 370, Necker Faculty of Medicine, Necker-Enfants Malades Hospital, Paris 75015, France. paterlini@necker.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12813464

Citation

Paterlini-Bréchot, Patrizia, et al. "Hepatitis B Virus-related Insertional Mutagenesis Occurs Frequently in Human Liver Cancers and Recurrently Targets Human Telomerase Gene." Oncogene, vol. 22, no. 25, 2003, pp. 3911-6.
Paterlini-Bréchot P, Saigo K, Murakami Y, et al. Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene. Oncogene. 2003;22(25):3911-6.
Paterlini-Bréchot, P., Saigo, K., Murakami, Y., Chami, M., Gozuacik, D., Mugnier, C., Lagorce, D., & Bréchot, C. (2003). Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene. Oncogene, 22(25), 3911-6.
Paterlini-Bréchot P, et al. Hepatitis B Virus-related Insertional Mutagenesis Occurs Frequently in Human Liver Cancers and Recurrently Targets Human Telomerase Gene. Oncogene. 2003 Jun 19;22(25):3911-6. PubMed PMID: 12813464.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene. AU - Paterlini-Bréchot,Patrizia, AU - Saigo,Kenichi, AU - Murakami,Yoshiki, AU - Chami,Mounia, AU - Gozuacik,Devrim, AU - Mugnier,Claude, AU - Lagorce,David, AU - Bréchot,Christian, PY - 2003/6/19/pubmed PY - 2003/7/25/medline PY - 2003/6/19/entrez SP - 3911 EP - 6 JF - Oncogene JO - Oncogene VL - 22 IS - 25 N2 - Integration of Hepatitis B Virus (HBV) DNA into liver cell DNA has been well established, but its implication in liver carcinogenesis is still being debated. In particular, insertion of the viral genome into cellular genes has been viewed as a rare event. By using HBV-Alu PCR, we have now isolated, from nine hepatocellular carcinomas, nine HBV-DNA integration sites showing that the viral genome mutates key regulatory cellular genes: neurotropic tyrosin receptor kinase 2 (NTRK2) gene, IL-1R-associated kinase 2 (IRAK2) gene, p42 mitogen-activated protein kinase 1 (p42MAPK1) gene, inositol 1,4,5-triphosphate receptor type 2 (IP3R2) gene, inositol 1,4,5-triphosphate receptor (IP3R) type 1 (IP3R1) gene, alpha 2,3 sialyltransferase (ST3GAL VI or SITA) gene, thyroid hormone uncoupling protein (TRUP) gene, EMX2-like gene, and human telomerase reverse transcriptase (hTERT) gene. This result brings to 15 the total number of genes targeted by HBV in a study of 22 human liver cancers. Overall, we found that both the inositol 1,4,5-triphosphate receptor gene and the telomerase gene were targeted by HBV in two different tumors. Thus, HBV frequently targets cellular genes involved in cell signalling and some of them may be preferential targets of the viral integration. SN - 0950-9232 UR - https://www.unboundmedicine.com/medline/citation/12813464/Hepatitis_B_virus_related_insertional_mutagenesis_occurs_frequently_in_human_liver_cancers_and_recurrently_targets_human_telomerase_gene_ L2 - https://doi.org/10.1038/sj.onc.1206492 DB - PRIME DP - Unbound Medicine ER -