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Risk of hepatocellular carcinoma and habits of alcohol drinking, betel quid chewing and cigarette smoking: a cohort of 2416 HBsAg-seropositive and 9421 HBsAg-seronegative male residents in Taiwan.
Cancer Causes Control. 2003 Apr; 14(3):241-50.CC

Abstract

OBJECTIVES

Hepatitis B virus (HBV) is a major cause of hepatocellular carcinoma (HCC) in the world. The specific aim of this study is to assess the associations between the risk of HCC and habits of alcohol drinking, betel quid chewing and cigarette smoking among subjects with and without chronic HBV infection.

METHODS

A total of 11,837 male residents in Taiwan were recruited in this community-based cohort study. Hepatitis B surface antigen (HBsAg) and antibody against hepatitis C virus (anti-HCV) in serum were determined by enzyme immunoassay, and the habits of alcohol drinking, betel quid chewing and cigarette smoking were collected through standardized personal interview according to a structured questionnaire. During the follow-up period of 91,885 person-years, 115 incident HCC cases were identified through data linkage with national cancer registry profile. The relative risk (RR) of developing HCC for habits of various substance use and chronic HBV infection were estimated by Cox's proportional hazards regression analyses.

RESULTS

Significantly increased HCC risk was observed for seropositives of HBsAg or anti-HCV, alcohol drinkers, betel quid chewers and cigarette smokers. There was a significant dose-response relationship between the risk of HCC and the number of habits of substance use. The highest multivariate-adjusted HCC risk was observed among HBsAg-seropositive substance users (RRs: 17.9-26.9), followed by HBsAg-seropositive non-users (RRs: 13.1-19.2), HBsAg-seronegative substance users (RRs: 1.6-2.7) and HBsAg-seronegative non-users (referent with RR = 1). The multivariate-adjusted relative HCC risks for habits of use of various substances were more profound among HBsAg-seronegatives than HBsAg-seropositive ones.

CONCLUSION

Habitual alcohol drinking, betel quid chewing and cigarette smoking are associated with an increased risk of HCC. Abstinence from substance use is important for the prevention of HCC in areas where chronic HBV infection is endemic.

Authors+Show Affiliations

Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan, ROC.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12814203

Citation

Wang, Li-Yu, et al. "Risk of Hepatocellular Carcinoma and Habits of Alcohol Drinking, Betel Quid Chewing and Cigarette Smoking: a Cohort of 2416 HBsAg-seropositive and 9421 HBsAg-seronegative Male Residents in Taiwan." Cancer Causes & Control : CCC, vol. 14, no. 3, 2003, pp. 241-50.
Wang LY, You SL, Lu SN, et al. Risk of hepatocellular carcinoma and habits of alcohol drinking, betel quid chewing and cigarette smoking: a cohort of 2416 HBsAg-seropositive and 9421 HBsAg-seronegative male residents in Taiwan. Cancer Causes Control. 2003;14(3):241-50.
Wang, L. Y., You, S. L., Lu, S. N., Ho, H. C., Wu, M. H., Sun, C. A., Yang, H. I., & Chien-Jen, C. (2003). Risk of hepatocellular carcinoma and habits of alcohol drinking, betel quid chewing and cigarette smoking: a cohort of 2416 HBsAg-seropositive and 9421 HBsAg-seronegative male residents in Taiwan. Cancer Causes & Control : CCC, 14(3), 241-50.
Wang LY, et al. Risk of Hepatocellular Carcinoma and Habits of Alcohol Drinking, Betel Quid Chewing and Cigarette Smoking: a Cohort of 2416 HBsAg-seropositive and 9421 HBsAg-seronegative Male Residents in Taiwan. Cancer Causes Control. 2003;14(3):241-50. PubMed PMID: 12814203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of hepatocellular carcinoma and habits of alcohol drinking, betel quid chewing and cigarette smoking: a cohort of 2416 HBsAg-seropositive and 9421 HBsAg-seronegative male residents in Taiwan. AU - Wang,Li-Yu, AU - You,San-Lin, AU - Lu,Sheng-Nan, AU - Ho,Hsi-Chang, AU - Wu,Mei-Hui, AU - Sun,Chien-An, AU - Yang,Hwai-I, AU - Chien-Jen,Chen, PY - 2003/6/20/pubmed PY - 2003/9/17/medline PY - 2003/6/20/entrez SP - 241 EP - 50 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 14 IS - 3 N2 - OBJECTIVES: Hepatitis B virus (HBV) is a major cause of hepatocellular carcinoma (HCC) in the world. The specific aim of this study is to assess the associations between the risk of HCC and habits of alcohol drinking, betel quid chewing and cigarette smoking among subjects with and without chronic HBV infection. METHODS: A total of 11,837 male residents in Taiwan were recruited in this community-based cohort study. Hepatitis B surface antigen (HBsAg) and antibody against hepatitis C virus (anti-HCV) in serum were determined by enzyme immunoassay, and the habits of alcohol drinking, betel quid chewing and cigarette smoking were collected through standardized personal interview according to a structured questionnaire. During the follow-up period of 91,885 person-years, 115 incident HCC cases were identified through data linkage with national cancer registry profile. The relative risk (RR) of developing HCC for habits of various substance use and chronic HBV infection were estimated by Cox's proportional hazards regression analyses. RESULTS: Significantly increased HCC risk was observed for seropositives of HBsAg or anti-HCV, alcohol drinkers, betel quid chewers and cigarette smokers. There was a significant dose-response relationship between the risk of HCC and the number of habits of substance use. The highest multivariate-adjusted HCC risk was observed among HBsAg-seropositive substance users (RRs: 17.9-26.9), followed by HBsAg-seropositive non-users (RRs: 13.1-19.2), HBsAg-seronegative substance users (RRs: 1.6-2.7) and HBsAg-seronegative non-users (referent with RR = 1). The multivariate-adjusted relative HCC risks for habits of use of various substances were more profound among HBsAg-seronegatives than HBsAg-seropositive ones. CONCLUSION: Habitual alcohol drinking, betel quid chewing and cigarette smoking are associated with an increased risk of HCC. Abstinence from substance use is important for the prevention of HCC in areas where chronic HBV infection is endemic. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/12814203/Risk_of_hepatocellular_carcinoma_and_habits_of_alcohol_drinking_betel_quid_chewing_and_cigarette_smoking:_a_cohort_of_2416_HBsAg_seropositive_and_9421_HBsAg_seronegative_male_residents_in_Taiwan_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=12814203.ui DB - PRIME DP - Unbound Medicine ER -