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Non-steroidal anti-inflammatory drug use and risk of adult leukemia.

Abstract

Epidemiological studies have suggested that regular use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) may be associated with reduced risk of some types of malignancy. Leukemia incidence and self-reported aspirin, as well as other NSAID use, was examined in a prospective cohort of >28,000 postmenopausal women. Eighty-one incident leukemia cases occurred during the period 1993-2000. The multivariate-adjusted relative risk of leukemia was 0.45 (95% confidence interval: 0.27-0.75) for women who reported using aspirin two or more times per week compared with women who reported no use. Similar inverse associations were observed for the two subtypes of leukemia analyzed. In contrast, for women who reported using nonaspirin NSAIDs, the multivariate-adjusted relative risk of leukemia was 1.31 (95% confidence interval: 0.77-2.22). Analyses that excluded cases diagnosed before 1995 did not notably alter results. To our knowledge, this is the first prospective study to examine the association between NSAID use and incident adult leukemia. Although preliminary, the notable differences observed in leukemia risk between aspirin and nonaspirin NSAID use warrant further investigation.

Authors+Show Affiliations

Division of Epidemiology, University of Minnesota School of Public Health, Minneapolis, Minnesota 55454, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12814999

Citation

Kasum, Christine M., et al. "Non-steroidal Anti-inflammatory Drug Use and Risk of Adult Leukemia." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 12, no. 6, 2003, pp. 534-7.
Kasum CM, Blair CK, Folsom AR, et al. Non-steroidal anti-inflammatory drug use and risk of adult leukemia. Cancer Epidemiol Biomarkers Prev. 2003;12(6):534-7.
Kasum, C. M., Blair, C. K., Folsom, A. R., & Ross, J. A. (2003). Non-steroidal anti-inflammatory drug use and risk of adult leukemia. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 12(6), pp. 534-7.
Kasum CM, et al. Non-steroidal Anti-inflammatory Drug Use and Risk of Adult Leukemia. Cancer Epidemiol Biomarkers Prev. 2003;12(6):534-7. PubMed PMID: 12814999.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-steroidal anti-inflammatory drug use and risk of adult leukemia. AU - Kasum,Christine M, AU - Blair,Cindy K, AU - Folsom,Aaron R, AU - Ross,Julie A, PY - 2003/6/20/pubmed PY - 2004/2/6/medline PY - 2003/6/20/entrez SP - 534 EP - 7 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 12 IS - 6 N2 - Epidemiological studies have suggested that regular use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) may be associated with reduced risk of some types of malignancy. Leukemia incidence and self-reported aspirin, as well as other NSAID use, was examined in a prospective cohort of >28,000 postmenopausal women. Eighty-one incident leukemia cases occurred during the period 1993-2000. The multivariate-adjusted relative risk of leukemia was 0.45 (95% confidence interval: 0.27-0.75) for women who reported using aspirin two or more times per week compared with women who reported no use. Similar inverse associations were observed for the two subtypes of leukemia analyzed. In contrast, for women who reported using nonaspirin NSAIDs, the multivariate-adjusted relative risk of leukemia was 1.31 (95% confidence interval: 0.77-2.22). Analyses that excluded cases diagnosed before 1995 did not notably alter results. To our knowledge, this is the first prospective study to examine the association between NSAID use and incident adult leukemia. Although preliminary, the notable differences observed in leukemia risk between aspirin and nonaspirin NSAID use warrant further investigation. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/12814999/Non_steroidal_anti_inflammatory_drug_use_and_risk_of_adult_leukemia_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=12814999 DB - PRIME DP - Unbound Medicine ER -