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Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats.
J Biochem Mol Toxicol. 2003; 17(3):193-9.JB

Abstract

Free radicals and oxidative stress have been implicated in the etiology of diabetes and its complications. This in vivo study has examined whether subacute administration of pycnogenol, a French pine bark extract containing procyanidins that have strong antioxidant potential, alters biomarkers of oxidative stress in normal and diabetic rats. Diabetes was induced in female Sprague-Dawley rats by a single injection of streptozotocin (90 mg/kg body weight, ip), resulting (after 30 days) in subnormal body weight, increased serum glucose concentrations, and an increase in liver weight, liver/body weight ratios, total and glycated hemoglobin, and serum aspartate aminotransferase activity. Normal and diabetic rats were treated with pycnogenol (10 mg/kg body weight/day, ip) for 14 days. Pycnogenol treatment significantly reduced blood glucose concentrations in diabetic rats. Biochemical markers for oxidative stress were assessed in the liver, kidney, and heart. Elevated hepatic catalase activity in diabetic rats was restored to normal levels after pycnogenol treatment. Additionally, diabetic rats treated with pycnogenol had significantly elevated levels of reduced glutathione and glutathione redox enzyme activities. The results demonstrate that pycnogenol alters intracellular antioxidant defense mechanisms in streptozotocin-induced diabetic rats.

Authors+Show Affiliations

Moi University Faculty of Health Sciences, Eldoret, Kenya.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12815616

Citation

Maritim, A, et al. "Effects of Pycnogenol Treatment On Oxidative Stress in Streptozotocin-induced Diabetic Rats." Journal of Biochemical and Molecular Toxicology, vol. 17, no. 3, 2003, pp. 193-9.
Maritim A, Dene BA, Sanders RA, et al. Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol. 2003;17(3):193-9.
Maritim, A., Dene, B. A., Sanders, R. A., & Watkins, J. B. (2003). Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats. Journal of Biochemical and Molecular Toxicology, 17(3), 193-9.
Maritim A, et al. Effects of Pycnogenol Treatment On Oxidative Stress in Streptozotocin-induced Diabetic Rats. J Biochem Mol Toxicol. 2003;17(3):193-9. PubMed PMID: 12815616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats. AU - Maritim,A, AU - Dene,B A, AU - Sanders,R A, AU - Watkins,J B,3rd PY - 2003/6/20/pubmed PY - 2004/4/24/medline PY - 2003/6/20/entrez SP - 193 EP - 9 JF - Journal of biochemical and molecular toxicology JO - J Biochem Mol Toxicol VL - 17 IS - 3 N2 - Free radicals and oxidative stress have been implicated in the etiology of diabetes and its complications. This in vivo study has examined whether subacute administration of pycnogenol, a French pine bark extract containing procyanidins that have strong antioxidant potential, alters biomarkers of oxidative stress in normal and diabetic rats. Diabetes was induced in female Sprague-Dawley rats by a single injection of streptozotocin (90 mg/kg body weight, ip), resulting (after 30 days) in subnormal body weight, increased serum glucose concentrations, and an increase in liver weight, liver/body weight ratios, total and glycated hemoglobin, and serum aspartate aminotransferase activity. Normal and diabetic rats were treated with pycnogenol (10 mg/kg body weight/day, ip) for 14 days. Pycnogenol treatment significantly reduced blood glucose concentrations in diabetic rats. Biochemical markers for oxidative stress were assessed in the liver, kidney, and heart. Elevated hepatic catalase activity in diabetic rats was restored to normal levels after pycnogenol treatment. Additionally, diabetic rats treated with pycnogenol had significantly elevated levels of reduced glutathione and glutathione redox enzyme activities. The results demonstrate that pycnogenol alters intracellular antioxidant defense mechanisms in streptozotocin-induced diabetic rats. SN - 1095-6670 UR - https://www.unboundmedicine.com/medline/citation/12815616/Effects_of_pycnogenol_treatment_on_oxidative_stress_in_streptozotocin_induced_diabetic_rats_ L2 - https://doi.org/10.1002/jbt.10078 DB - PRIME DP - Unbound Medicine ER -