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Quantification of neuroepithelial bodies and their innervation in fawn-hooded and Wistar rat lungs.
Am J Respir Cell Mol Biol 2004; 30(1):20-30AJ

Abstract

The Fawn-Hooded rat (FHR), a model for primary pulmonary hypertension, shows an unexplained hypersensitivity to airway hypoxia. Because pulmonary neuroepithelial bodies (NEBs) appear to express a functional oxygen-sensing mechanism and an extensive sensory innervation, possible changes in this system should be taken into consideration. In the present study a comparative analysis of NEBs and their selective innervation was performed in FHRs and Wistar control rats. In both rat strains, the number of NEBs was estimated to be around 3,500, approximately 40% of which were innervated by vagal sensory calbindin D28k-immunoreactive (IR) nerve endings and approximately 50% by spinal sensory calcitonin gene-related peptide (CGRP)-IR nerve terminals. The number of intrinsic pulmonary nitrergic neurons and the percentage of pulmonary NEBs revealing a nitrergic innervation were highly significantly lower in FHRs. In both FHRs and Wistar rats, a remarkable morphologic interaction was observed between the intrinsic nitrergic and the CGRP-IR sensory population contacting NEBs. Our findings suggest a possible link between the hypersensitivity to airway hypoxia observed in FHRs and a reduced intrinsic pulmonary nitrergic innervation, possibly via the interaction with pulmonary NEBs and their spinal sensory CGRP-IR innervation.

Authors+Show Affiliations

Department of Biomedical Sciences, University of Antwerp-RUCA, Groenenborgerlaan 171, B-2020 Antwerp, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12816734

Citation

Van Genechten, Jeroen, et al. "Quantification of Neuroepithelial Bodies and Their Innervation in Fawn-hooded and Wistar Rat Lungs." American Journal of Respiratory Cell and Molecular Biology, vol. 30, no. 1, 2004, pp. 20-30.
Van Genechten J, Brouns I, Burnstock G, et al. Quantification of neuroepithelial bodies and their innervation in fawn-hooded and Wistar rat lungs. Am J Respir Cell Mol Biol. 2004;30(1):20-30.
Van Genechten, J., Brouns, I., Burnstock, G., Timmermans, J. P., & Adriaensen, D. (2004). Quantification of neuroepithelial bodies and their innervation in fawn-hooded and Wistar rat lungs. American Journal of Respiratory Cell and Molecular Biology, 30(1), pp. 20-30.
Van Genechten J, et al. Quantification of Neuroepithelial Bodies and Their Innervation in Fawn-hooded and Wistar Rat Lungs. Am J Respir Cell Mol Biol. 2004;30(1):20-30. PubMed PMID: 12816734.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantification of neuroepithelial bodies and their innervation in fawn-hooded and Wistar rat lungs. AU - Van Genechten,Jeroen, AU - Brouns,Inge, AU - Burnstock,Geoff, AU - Timmermans,Jean-Pierre, AU - Adriaensen,Dirk, Y1 - 2003/06/19/ PY - 2003/6/21/pubmed PY - 2004/2/26/medline PY - 2003/6/21/entrez SP - 20 EP - 30 JF - American journal of respiratory cell and molecular biology JO - Am. J. Respir. Cell Mol. Biol. VL - 30 IS - 1 N2 - The Fawn-Hooded rat (FHR), a model for primary pulmonary hypertension, shows an unexplained hypersensitivity to airway hypoxia. Because pulmonary neuroepithelial bodies (NEBs) appear to express a functional oxygen-sensing mechanism and an extensive sensory innervation, possible changes in this system should be taken into consideration. In the present study a comparative analysis of NEBs and their selective innervation was performed in FHRs and Wistar control rats. In both rat strains, the number of NEBs was estimated to be around 3,500, approximately 40% of which were innervated by vagal sensory calbindin D28k-immunoreactive (IR) nerve endings and approximately 50% by spinal sensory calcitonin gene-related peptide (CGRP)-IR nerve terminals. The number of intrinsic pulmonary nitrergic neurons and the percentage of pulmonary NEBs revealing a nitrergic innervation were highly significantly lower in FHRs. In both FHRs and Wistar rats, a remarkable morphologic interaction was observed between the intrinsic nitrergic and the CGRP-IR sensory population contacting NEBs. Our findings suggest a possible link between the hypersensitivity to airway hypoxia observed in FHRs and a reduced intrinsic pulmonary nitrergic innervation, possibly via the interaction with pulmonary NEBs and their spinal sensory CGRP-IR innervation. SN - 1044-1549 UR - https://www.unboundmedicine.com/medline/citation/12816734/Quantification_of_neuroepithelial_bodies_and_their_innervation_in_fawn_hooded_and_Wistar_rat_lungs_ L2 - http://www.atsjournals.org/doi/full/10.1165/rcmb.2003-0097OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -