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Effects of dietary monounsaturated fatty acids on lipoprotein concentrations, compositions, and subfraction distributions and on VLDL apolipoprotein B kinetics: dose-dependent effects on LDL.
Am J Clin Nutr. 2003 Jul; 78(1):47-56.AJ

Abstract

BACKGROUND

Replacing dietary saturated fatty acids (SFAs) with monounsaturated fatty acids (MUFAs) lowers LDL cholesterol, but the underlying mechanisms remain unclear.

OBJECTIVE

We assessed the effects of replacing dietary SFAs with MUFAs on concentrations and subclass distributions of VLDL, intermediate-density lipoprotein, LDL, and HDL and on VLDL apolipoprotein B kinetics.

DESIGN

Thirty-five moderately hypercholesterolemic, middle-aged volunteers consumed for 6 wk, in random order, diets containing low (L-MUFA; 7.8% of energy from MUFAs), moderate (M-MUFA; 10.3% from MUFAs), or high (H-MUFA; 13.7% from MUFAs) amounts of MUFAs. Fasting blood samples were taken from all subjects after each intervention. VLDL apolipoprotein B kinetic studies were performed in a subgroup after the L-MUFA and H-MUFA diets.

RESULTS

Plasma cholesterol concentrations decreased in a dose-dependent manner with increasing intakes of dietary MUFAs. This change was entirely accounted for by reduced LDL cholesterol (-0.20 and -0.49 mmol/L after the M-MUFA and H-MUFA diets, respectively, compared with the concentration after the L-MUFA diet; P for trend < 0.01). Plasma triacylglycerol and HDL cholesterol were not significantly affected by the dietary intervention, nor were the concentrations of VLDL(1) (S(f) 60-400), VLDL(2) (S(f) 20-60), or intermediate-density lipoprotein (S(f) 12-20). Production and catabolic rates for VLDL(1) and VLDL(2) were also unaffected. HDL and LDL subclass distributions were not significantly altered, but as a consequence of the overall LDL lowering, concentrations of atherogenic LDL-III were 25% lower after the H-MUFA diet than after the L-MUFA diet (P = 0.02).

CONCLUSION

The effects of replacing dietary SFAs with MUFAs on lipoprotein metabolism appear to be almost exclusively limited to the LDL density class.

Authors+Show Affiliations

Department of Pathological Biochemistry, University of Glasgow, Glasgow, United Kingdom . j.gill@bio.gla.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12816770

Citation

Gill, Jason M R., et al. "Effects of Dietary Monounsaturated Fatty Acids On Lipoprotein Concentrations, Compositions, and Subfraction Distributions and On VLDL Apolipoprotein B Kinetics: Dose-dependent Effects On LDL." The American Journal of Clinical Nutrition, vol. 78, no. 1, 2003, pp. 47-56.
Gill JM, Brown JC, Caslake MJ, et al. Effects of dietary monounsaturated fatty acids on lipoprotein concentrations, compositions, and subfraction distributions and on VLDL apolipoprotein B kinetics: dose-dependent effects on LDL. Am J Clin Nutr. 2003;78(1):47-56.
Gill, J. M., Brown, J. C., Caslake, M. J., Wright, D. M., Cooney, J., Bedford, D., Hughes, D. A., Stanley, J. C., & Packard, C. J. (2003). Effects of dietary monounsaturated fatty acids on lipoprotein concentrations, compositions, and subfraction distributions and on VLDL apolipoprotein B kinetics: dose-dependent effects on LDL. The American Journal of Clinical Nutrition, 78(1), 47-56.
Gill JM, et al. Effects of Dietary Monounsaturated Fatty Acids On Lipoprotein Concentrations, Compositions, and Subfraction Distributions and On VLDL Apolipoprotein B Kinetics: Dose-dependent Effects On LDL. Am J Clin Nutr. 2003;78(1):47-56. PubMed PMID: 12816770.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of dietary monounsaturated fatty acids on lipoprotein concentrations, compositions, and subfraction distributions and on VLDL apolipoprotein B kinetics: dose-dependent effects on LDL. AU - Gill,Jason M R, AU - Brown,Jacqueline C, AU - Caslake,Muriel J, AU - Wright,Dawn M, AU - Cooney,Josephine, AU - Bedford,Dorothy, AU - Hughes,David A, AU - Stanley,John C, AU - Packard,Chris J, PY - 2003/6/21/pubmed PY - 2003/7/9/medline PY - 2003/6/21/entrez SP - 47 EP - 56 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 78 IS - 1 N2 - BACKGROUND: Replacing dietary saturated fatty acids (SFAs) with monounsaturated fatty acids (MUFAs) lowers LDL cholesterol, but the underlying mechanisms remain unclear. OBJECTIVE: We assessed the effects of replacing dietary SFAs with MUFAs on concentrations and subclass distributions of VLDL, intermediate-density lipoprotein, LDL, and HDL and on VLDL apolipoprotein B kinetics. DESIGN: Thirty-five moderately hypercholesterolemic, middle-aged volunteers consumed for 6 wk, in random order, diets containing low (L-MUFA; 7.8% of energy from MUFAs), moderate (M-MUFA; 10.3% from MUFAs), or high (H-MUFA; 13.7% from MUFAs) amounts of MUFAs. Fasting blood samples were taken from all subjects after each intervention. VLDL apolipoprotein B kinetic studies were performed in a subgroup after the L-MUFA and H-MUFA diets. RESULTS: Plasma cholesterol concentrations decreased in a dose-dependent manner with increasing intakes of dietary MUFAs. This change was entirely accounted for by reduced LDL cholesterol (-0.20 and -0.49 mmol/L after the M-MUFA and H-MUFA diets, respectively, compared with the concentration after the L-MUFA diet; P for trend < 0.01). Plasma triacylglycerol and HDL cholesterol were not significantly affected by the dietary intervention, nor were the concentrations of VLDL(1) (S(f) 60-400), VLDL(2) (S(f) 20-60), or intermediate-density lipoprotein (S(f) 12-20). Production and catabolic rates for VLDL(1) and VLDL(2) were also unaffected. HDL and LDL subclass distributions were not significantly altered, but as a consequence of the overall LDL lowering, concentrations of atherogenic LDL-III were 25% lower after the H-MUFA diet than after the L-MUFA diet (P = 0.02). CONCLUSION: The effects of replacing dietary SFAs with MUFAs on lipoprotein metabolism appear to be almost exclusively limited to the LDL density class. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/12816770/Effects_of_dietary_monounsaturated_fatty_acids_on_lipoprotein_concentrations_compositions_and_subfraction_distributions_and_on_VLDL_apolipoprotein_B_kinetics:_dose_dependent_effects_on_LDL_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/78.1.47 DB - PRIME DP - Unbound Medicine ER -