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Estrogen receptor alpha gene polymorphisms and peak bone density in Chinese nuclear families.
J Bone Miner Res. 2003 Jun; 18(6):1028-35.JB

Abstract

PBD is an important determinant of osteoporotic fractures. Few studies were performed to search for genes underlying PBD variation in Chinese populations. We tested linkage and/or association of the estrogen receptor alpha gene polymorphism with PBD in 401 Chinese nuclear families. This study suggests the ER-alpha gene may have some minor effects on PBM variation in the Chinese population. Low peak bone density (PBD) in adulthood is an important determinant of osteoporotic fractures in the elderly. PBD variation is mainly regulated by genetic factors. Extensive molecular genetics studies have been performed to search for genes underlying PBD variation, largely in whites. Few studies were performed in Chinese populations. In this study, we simultaneously test linkage and/or association of the estrogen receptor alpha (ER-alpha) gene polymorphism with PBD in 401 Chinese nuclear families (both parents plus their female children) of 1260 subjects, with the 458 children generally between 20 and 40 years of age. All the subjects were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) at polymorphic PvuII and XbaI sites inside the ER-alpha gene. Bone mineral density was measured at the lumbar spine (L1-L4) and hip (femoral neck, trochanter, and intertrochanteric region). Raw bone mineral density values were adjusted by age, height, and weight as covariates. We detected marginally significant results for within-family association (transmission disequilibrium; p = 0.054) between the spine bone mineral density variation and the ER-alpha XbaI genotypes. For the hip bone mineral density variation, significant (p < 0.05) linkage results were generally found for the two intragenic markers. Analyses of the haplotypes defined by the two markers confer further evidence for linkage of the ER-alpha with the hip PBD variation. In conclusion, this study suggests that the ER-alpha gene may have minor effects on PBD variation in our Chinese population.

Authors+Show Affiliations

Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Hunan, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12817755

Citation

Qin, Yue-Juan, et al. "Estrogen Receptor Alpha Gene Polymorphisms and Peak Bone Density in Chinese Nuclear Families." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 18, no. 6, 2003, pp. 1028-35.
Qin YJ, Shen H, Huang QR, et al. Estrogen receptor alpha gene polymorphisms and peak bone density in Chinese nuclear families. J Bone Miner Res. 2003;18(6):1028-35.
Qin, Y. J., Shen, H., Huang, Q. R., Zhao, L. J., Zhou, Q., Li, M. X., He, J. W., Mo, X. Y., Lu, J. H., Recker, R. R., & Deng, H. W. (2003). Estrogen receptor alpha gene polymorphisms and peak bone density in Chinese nuclear families. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 18(6), 1028-35.
Qin YJ, et al. Estrogen Receptor Alpha Gene Polymorphisms and Peak Bone Density in Chinese Nuclear Families. J Bone Miner Res. 2003;18(6):1028-35. PubMed PMID: 12817755.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estrogen receptor alpha gene polymorphisms and peak bone density in Chinese nuclear families. AU - Qin,Yue-Juan, AU - Shen,Hui, AU - Huang,Qi-Ren, AU - Zhao,Lan-Juan, AU - Zhou,Qi, AU - Li,Miao-Xin, AU - He,Jin-Wei, AU - Mo,Xiao-Yang, AU - Lu,Jing-Hui, AU - Recker,Robert R, AU - Deng,Hong-Wen, PY - 2003/6/24/pubmed PY - 2004/2/12/medline PY - 2003/6/24/entrez SP - 1028 EP - 35 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J Bone Miner Res VL - 18 IS - 6 N2 - PBD is an important determinant of osteoporotic fractures. Few studies were performed to search for genes underlying PBD variation in Chinese populations. We tested linkage and/or association of the estrogen receptor alpha gene polymorphism with PBD in 401 Chinese nuclear families. This study suggests the ER-alpha gene may have some minor effects on PBM variation in the Chinese population. Low peak bone density (PBD) in adulthood is an important determinant of osteoporotic fractures in the elderly. PBD variation is mainly regulated by genetic factors. Extensive molecular genetics studies have been performed to search for genes underlying PBD variation, largely in whites. Few studies were performed in Chinese populations. In this study, we simultaneously test linkage and/or association of the estrogen receptor alpha (ER-alpha) gene polymorphism with PBD in 401 Chinese nuclear families (both parents plus their female children) of 1260 subjects, with the 458 children generally between 20 and 40 years of age. All the subjects were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) at polymorphic PvuII and XbaI sites inside the ER-alpha gene. Bone mineral density was measured at the lumbar spine (L1-L4) and hip (femoral neck, trochanter, and intertrochanteric region). Raw bone mineral density values were adjusted by age, height, and weight as covariates. We detected marginally significant results for within-family association (transmission disequilibrium; p = 0.054) between the spine bone mineral density variation and the ER-alpha XbaI genotypes. For the hip bone mineral density variation, significant (p < 0.05) linkage results were generally found for the two intragenic markers. Analyses of the haplotypes defined by the two markers confer further evidence for linkage of the ER-alpha with the hip PBD variation. In conclusion, this study suggests that the ER-alpha gene may have minor effects on PBD variation in our Chinese population. SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/12817755/Estrogen_receptor_alpha_gene_polymorphisms_and_peak_bone_density_in_Chinese_nuclear_families_ L2 - https://doi.org/10.1359/jbmr.2003.18.6.1028 DB - PRIME DP - Unbound Medicine ER -