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Characterization of prediagnostic symptoms among primary epithelial ovarian cancer cases and controls.
Gynecol Oncol 2003; 90(1):75-82GO

Abstract

OBJECTIVE

The goal of this study was to characterize types, frequency, combinations, and relative onset of symptoms among ovarian cancer cases and controls.

METHODS

Participants were from an ongoing, population-based, case-control study of primary epithelial ovarian cancer in a 48-country region of North Carolina. Incident cases (N = 267), aged 20-74, were identified by area hospitals on a rapid case ascertainment basis between April 1999 and March 2001. Population-based controls, with at least one intact ovary, frequency matched on age and race, were identified using random-digit dialing (N = 287) and Health Care Financing Administration (HCFA) phone lists (N = 30). Trained nurse-interviewers, using a standardized questionnaire, asked participants about specific symptoms experienced for at least 2 weeks in the year prior to diagnosis (cases)/interview (controls).

RESULTS

More than 90% of cases reported at least one symptom and symptoms were most often the reason for the doctor visit leading to diagnosis (74%), followed by routine examination (12%). Among invasive cases, symptoms with onsets longer before diagnosis (median 5-7 months) included gas/nausea/indigestion; urinary frequency/urgency; bowel irregularity; abnormal menstrual/vaginal bleeding or discharge; pain during intercourse; and ongoing fatigue. Symptoms with onsets closer to diagnosis (median of 2-4 months) included distended/hard abdomen; bloating/feeling of fullness; unexplained weight gain/loss; pelvic/abdominal discomfort; chest pain/respiratory difficulties; and "other" symptoms. Controls reported fewer symptoms than cases (median 1 vs 5 or 6). Control symptoms were of longer duration and much less likely to occur in combination.

CONCLUSION

Earlier diagnosis of ovarian cancer may be possible if women and physicians recognize the importance of combinations of seemingly unrelated symptoms, especially those identified as occurring longer before diagnosis.

Authors+Show Affiliations

Cancer Prevention, Detection and Control Research Program, Box 2949, Duke University Medical Center, Durham, NC 27710, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12821345

Citation

Vine, Marilyn F., et al. "Characterization of Prediagnostic Symptoms Among Primary Epithelial Ovarian Cancer Cases and Controls." Gynecologic Oncology, vol. 90, no. 1, 2003, pp. 75-82.
Vine MF, Calingaert B, Berchuck A, et al. Characterization of prediagnostic symptoms among primary epithelial ovarian cancer cases and controls. Gynecol Oncol. 2003;90(1):75-82.
Vine, M. F., Calingaert, B., Berchuck, A., & Schildkraut, J. M. (2003). Characterization of prediagnostic symptoms among primary epithelial ovarian cancer cases and controls. Gynecologic Oncology, 90(1), pp. 75-82.
Vine MF, et al. Characterization of Prediagnostic Symptoms Among Primary Epithelial Ovarian Cancer Cases and Controls. Gynecol Oncol. 2003;90(1):75-82. PubMed PMID: 12821345.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of prediagnostic symptoms among primary epithelial ovarian cancer cases and controls. AU - Vine,Marilyn F, AU - Calingaert,Brian, AU - Berchuck,Andrew, AU - Schildkraut,Joellen M, PY - 2003/6/25/pubmed PY - 2003/7/25/medline PY - 2003/6/25/entrez SP - 75 EP - 82 JF - Gynecologic oncology JO - Gynecol. Oncol. VL - 90 IS - 1 N2 - OBJECTIVE: The goal of this study was to characterize types, frequency, combinations, and relative onset of symptoms among ovarian cancer cases and controls. METHODS: Participants were from an ongoing, population-based, case-control study of primary epithelial ovarian cancer in a 48-country region of North Carolina. Incident cases (N = 267), aged 20-74, were identified by area hospitals on a rapid case ascertainment basis between April 1999 and March 2001. Population-based controls, with at least one intact ovary, frequency matched on age and race, were identified using random-digit dialing (N = 287) and Health Care Financing Administration (HCFA) phone lists (N = 30). Trained nurse-interviewers, using a standardized questionnaire, asked participants about specific symptoms experienced for at least 2 weeks in the year prior to diagnosis (cases)/interview (controls). RESULTS: More than 90% of cases reported at least one symptom and symptoms were most often the reason for the doctor visit leading to diagnosis (74%), followed by routine examination (12%). Among invasive cases, symptoms with onsets longer before diagnosis (median 5-7 months) included gas/nausea/indigestion; urinary frequency/urgency; bowel irregularity; abnormal menstrual/vaginal bleeding or discharge; pain during intercourse; and ongoing fatigue. Symptoms with onsets closer to diagnosis (median of 2-4 months) included distended/hard abdomen; bloating/feeling of fullness; unexplained weight gain/loss; pelvic/abdominal discomfort; chest pain/respiratory difficulties; and "other" symptoms. Controls reported fewer symptoms than cases (median 1 vs 5 or 6). Control symptoms were of longer duration and much less likely to occur in combination. CONCLUSION: Earlier diagnosis of ovarian cancer may be possible if women and physicians recognize the importance of combinations of seemingly unrelated symptoms, especially those identified as occurring longer before diagnosis. SN - 0090-8258 UR - https://www.unboundmedicine.com/medline/citation/12821345/Characterization_of_prediagnostic_symptoms_among_primary_epithelial_ovarian_cancer_cases_and_controls_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090825803001756 DB - PRIME DP - Unbound Medicine ER -