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Effects on the right motor hand-area excitability produced by low-frequency rTMS over human contralateral homologous cortex.
J Physiol. 2003 Sep 01; 551(Pt 2):563-73.JP

Abstract

Repetitive transcranial magnetic stimulation (rTMS) has long lasting effects on cortical excitability at the site of stimulation, on interconnected sites at a distance and on the connections between them. In the present experiments we have used the technique of transcallosal inhibition between the motor cortices to examine all three effects in the same protocol. Ten healthy subjects received 900 rTMS stimuli at 1 Hz from a figure of eight coil over the left motor hand area. The intensity of rTMS was above the threshold for inducing short latency interhemispherical inhibition with a single stimulus (equivalent to 115-120 % resting motor threshold). Before and after the rTMS we evaluated: (1) in the left hemisphere, the amplitude of motor-evoked potentials (MEPs), and contralateral and ipsilateral cortical silent periods (CSP, ISP); (2) in the right hemisphere, MEP, CSP, ISP and short-interval intracortical inhibition and intracortical facilitation (SICI/ICF), and (3) interhemispherical inhibition (IHI) from the left-to-right hemisphere using a paired-pulse method. There were two main effects after rTMS to the left hemisphere: first, the amplitude of MEPs from the right hemisphere increased; second, there was a reduction in the IHI from the left-to-right hemisphere at interstimulus intervals of 7 and 10 ms but not at longer intervals (15-75 ms). Control experiments showed that these effects were not due to afferent inputs produced by the muscle twitches induced during the rTMS. The data are compatible with the notion that rTMS to the left hemisphere leads to reduced interhemispherical inhibition of the right hemisphere and a consequent increase in corticospinal excitability in that hemisphere.

Authors+Show Affiliations

INM Neuromed IRCSS, Pozzilli, IS, University of Rome La Sapienza, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12821724

Citation

Gilio, Francesca, et al. "Effects On the Right Motor Hand-area Excitability Produced By Low-frequency rTMS Over Human Contralateral Homologous Cortex." The Journal of Physiology, vol. 551, no. Pt 2, 2003, pp. 563-73.
Gilio F, Rizzo V, Siebner HR, et al. Effects on the right motor hand-area excitability produced by low-frequency rTMS over human contralateral homologous cortex. J Physiol. 2003;551(Pt 2):563-73.
Gilio, F., Rizzo, V., Siebner, H. R., & Rothwell, J. C. (2003). Effects on the right motor hand-area excitability produced by low-frequency rTMS over human contralateral homologous cortex. The Journal of Physiology, 551(Pt 2), 563-73.
Gilio F, et al. Effects On the Right Motor Hand-area Excitability Produced By Low-frequency rTMS Over Human Contralateral Homologous Cortex. J Physiol. 2003 Sep 1;551(Pt 2):563-73. PubMed PMID: 12821724.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects on the right motor hand-area excitability produced by low-frequency rTMS over human contralateral homologous cortex. AU - Gilio,Francesca, AU - Rizzo,Vincenzo, AU - Siebner,Hartwig R, AU - Rothwell,John C, Y1 - 2003/06/23/ PY - 2003/6/25/pubmed PY - 2004/4/30/medline PY - 2003/6/25/entrez SP - 563 EP - 73 JF - The Journal of physiology JO - J Physiol VL - 551 IS - Pt 2 N2 - Repetitive transcranial magnetic stimulation (rTMS) has long lasting effects on cortical excitability at the site of stimulation, on interconnected sites at a distance and on the connections between them. In the present experiments we have used the technique of transcallosal inhibition between the motor cortices to examine all three effects in the same protocol. Ten healthy subjects received 900 rTMS stimuli at 1 Hz from a figure of eight coil over the left motor hand area. The intensity of rTMS was above the threshold for inducing short latency interhemispherical inhibition with a single stimulus (equivalent to 115-120 % resting motor threshold). Before and after the rTMS we evaluated: (1) in the left hemisphere, the amplitude of motor-evoked potentials (MEPs), and contralateral and ipsilateral cortical silent periods (CSP, ISP); (2) in the right hemisphere, MEP, CSP, ISP and short-interval intracortical inhibition and intracortical facilitation (SICI/ICF), and (3) interhemispherical inhibition (IHI) from the left-to-right hemisphere using a paired-pulse method. There were two main effects after rTMS to the left hemisphere: first, the amplitude of MEPs from the right hemisphere increased; second, there was a reduction in the IHI from the left-to-right hemisphere at interstimulus intervals of 7 and 10 ms but not at longer intervals (15-75 ms). Control experiments showed that these effects were not due to afferent inputs produced by the muscle twitches induced during the rTMS. The data are compatible with the notion that rTMS to the left hemisphere leads to reduced interhemispherical inhibition of the right hemisphere and a consequent increase in corticospinal excitability in that hemisphere. SN - 0022-3751 UR - https://www.unboundmedicine.com/medline/citation/12821724/Effects_on_the_right_motor_hand_area_excitability_produced_by_low_frequency_rTMS_over_human_contralateral_homologous_cortex_ L2 - https://doi.org/10.1113/jphysiol.2003.044313 DB - PRIME DP - Unbound Medicine ER -