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Prevalence of extra-oesophageal manifestations in gastro-oesophageal reflux disease: an analysis based on the ProGERD Study.
Aliment Pharmacol Ther 2003; 17(12):1515-20AP

Abstract

BACKGROUND AND AIMS

Gastro-oesophageal reflux disease (GERD) can be associated with a variety of extra-oesophageal disorders (EED) such as chronic cough, asthma, laryngeal disorder or chest pain. The aim of the study was to estimate and compare the prevalence of EED in a population with symptomatic GERD presenting as either erosive reflux disease (ERD) or non-erosive reflux disease (NERD).

METHODS

Baseline data were collected from a prospective, multicentre, open cohort study (ProGERD) in which patients will be followed for 5 years after initial treatment with esomeprazole. Within the framework of this trial, all patients underwent gastroscopy and filled out a questionnaire designed to assess EED. The influence of potential prognostic factors on the prevalence of EED was analysed by multivariate (stepwise logistic regression) analysis.

RESULTS

6215 patients (3303 male, 2912 female; mean age 54 years) presenting with heartburn were included. EED was detected in 32.8% of all patients. The proportion was significantly higher (P = 0.0002) in ERD patients (34.9%) than in NERD patients (30.5%). As judged from the multivariate analysis, female gender, age, oesophagitis of LA grade C/D, duration of GERD disease greater than 1 years and smoking were significantly associated with EED. ERD patients with oesophagitis of LA grade A or B did not have a significantly higher risk of EED than patients with NERD.

CONCLUSIONS

Patients with GERD have a high probability of experiencing EED, which may be associated with a number of prognostic factors such as duration and severity of GERD. Extra-oesophageal disorders are slightly, but statistically, more prevalent in ERD than in NERD patients.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12823154

Citation

Jaspersen, D, et al. "Prevalence of Extra-oesophageal Manifestations in Gastro-oesophageal Reflux Disease: an Analysis Based On the ProGERD Study." Alimentary Pharmacology & Therapeutics, vol. 17, no. 12, 2003, pp. 1515-20.
Jaspersen D, Kulig M, Labenz J, et al. Prevalence of extra-oesophageal manifestations in gastro-oesophageal reflux disease: an analysis based on the ProGERD Study. Aliment Pharmacol Ther. 2003;17(12):1515-20.
Jaspersen, D., Kulig, M., Labenz, J., Leodolter, A., Lind, T., Meyer-Sabellek, W., ... Malfertheiner, P. (2003). Prevalence of extra-oesophageal manifestations in gastro-oesophageal reflux disease: an analysis based on the ProGERD Study. Alimentary Pharmacology & Therapeutics, 17(12), pp. 1515-20.
Jaspersen D, et al. Prevalence of Extra-oesophageal Manifestations in Gastro-oesophageal Reflux Disease: an Analysis Based On the ProGERD Study. Aliment Pharmacol Ther. 2003 Jun 15;17(12):1515-20. PubMed PMID: 12823154.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of extra-oesophageal manifestations in gastro-oesophageal reflux disease: an analysis based on the ProGERD Study. AU - Jaspersen,D, AU - Kulig,M, AU - Labenz,J, AU - Leodolter,A, AU - Lind,T, AU - Meyer-Sabellek,W, AU - Vieth,M, AU - Willich,S N, AU - Lindner,D, AU - Stolte,M, AU - Malfertheiner,P, PY - 2003/6/26/pubmed PY - 2003/9/17/medline PY - 2003/6/26/entrez SP - 1515 EP - 20 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 17 IS - 12 N2 - BACKGROUND AND AIMS: Gastro-oesophageal reflux disease (GERD) can be associated with a variety of extra-oesophageal disorders (EED) such as chronic cough, asthma, laryngeal disorder or chest pain. The aim of the study was to estimate and compare the prevalence of EED in a population with symptomatic GERD presenting as either erosive reflux disease (ERD) or non-erosive reflux disease (NERD). METHODS: Baseline data were collected from a prospective, multicentre, open cohort study (ProGERD) in which patients will be followed for 5 years after initial treatment with esomeprazole. Within the framework of this trial, all patients underwent gastroscopy and filled out a questionnaire designed to assess EED. The influence of potential prognostic factors on the prevalence of EED was analysed by multivariate (stepwise logistic regression) analysis. RESULTS: 6215 patients (3303 male, 2912 female; mean age 54 years) presenting with heartburn were included. EED was detected in 32.8% of all patients. The proportion was significantly higher (P = 0.0002) in ERD patients (34.9%) than in NERD patients (30.5%). As judged from the multivariate analysis, female gender, age, oesophagitis of LA grade C/D, duration of GERD disease greater than 1 years and smoking were significantly associated with EED. ERD patients with oesophagitis of LA grade A or B did not have a significantly higher risk of EED than patients with NERD. CONCLUSIONS: Patients with GERD have a high probability of experiencing EED, which may be associated with a number of prognostic factors such as duration and severity of GERD. Extra-oesophageal disorders are slightly, but statistically, more prevalent in ERD than in NERD patients. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/12823154/Prevalence_of_extra_oesophageal_manifestations_in_gastro_oesophageal_reflux_disease:_an_analysis_based_on_the_ProGERD_Study_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0269-2813&date=2003&volume=17&issue=12&spage=1515 DB - PRIME DP - Unbound Medicine ER -