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No effect of creatine supplementation on human myofibrillar and sarcoplasmic protein synthesis after resistance exercise.
Am J Physiol Endocrinol Metab. 2003 Nov; 285(5):E1089-94.AJ

Abstract

Muscle hypertrophy during resistance training is reportedly increased by creatine supplementation. Having previously failed to find an anabolic effect on muscle protein turnover at rest, either fed or fasted, we have now examined the possibility of a stimulatory effect of creatine in conjunction with acute resistance exercise. Seven healthy men (body mass index, 23 +/- 2 kg/m2, 21 +/- 1 yr, means +/- SE) performed 20 x 10 repetitions of leg extension-flexion at 75% one-repetition maximum in one leg, on two occasions, 4 wk apart, before and after ingesting 21 g/day creatine for 5 days. The subjects ate approximately 21 g maltodextrin + 6 g protein/h for 3 h postexercise. We measured incorporation of [1-13C]leucine into quadriceps muscle proteins in the rested and exercised legs. Leg protein breakdown (as dilution of [2H5]phenylalanine) was also assessed in the exercised and rested leg postexercise. Creatine supplementation increased muscle total creatine by approximately 21% (P < 0.01). Exercise increased the synthetic rates of myofibrillar and sarcoplasmic proteins by two- to threefold (P < 0.05), and leg phenylalanine balance became more positive, but creatine was without any anabolic effect.

Authors+Show Affiliations

Université Catholique de Louvain, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12824083

Citation

Louis, Magali, et al. "No Effect of Creatine Supplementation On Human Myofibrillar and Sarcoplasmic Protein Synthesis After Resistance Exercise." American Journal of Physiology. Endocrinology and Metabolism, vol. 285, no. 5, 2003, pp. E1089-94.
Louis M, Poortmans JR, Francaux M, et al. No effect of creatine supplementation on human myofibrillar and sarcoplasmic protein synthesis after resistance exercise. Am J Physiol Endocrinol Metab. 2003;285(5):E1089-94.
Louis, M., Poortmans, J. R., Francaux, M., Berré, J., Boisseau, N., Brassine, E., Cuthbertson, D. J., Smith, K., Babraj, J. A., Waddell, T., & Rennie, M. J. (2003). No effect of creatine supplementation on human myofibrillar and sarcoplasmic protein synthesis after resistance exercise. American Journal of Physiology. Endocrinology and Metabolism, 285(5), E1089-94.
Louis M, et al. No Effect of Creatine Supplementation On Human Myofibrillar and Sarcoplasmic Protein Synthesis After Resistance Exercise. Am J Physiol Endocrinol Metab. 2003;285(5):E1089-94. PubMed PMID: 12824083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - No effect of creatine supplementation on human myofibrillar and sarcoplasmic protein synthesis after resistance exercise. AU - Louis,Magali, AU - Poortmans,Jacques R, AU - Francaux,Marc, AU - Berré,Jacques, AU - Boisseau,Nathalie, AU - Brassine,Eric, AU - Cuthbertson,Daniel J R, AU - Smith,Kenneth, AU - Babraj,John A, AU - Waddell,Tom, AU - Rennie,Michael J, Y1 - 2003/06/24/ PY - 2003/6/26/pubmed PY - 2003/12/3/medline PY - 2003/6/26/entrez SP - E1089 EP - 94 JF - American journal of physiology. Endocrinology and metabolism JO - Am J Physiol Endocrinol Metab VL - 285 IS - 5 N2 - Muscle hypertrophy during resistance training is reportedly increased by creatine supplementation. Having previously failed to find an anabolic effect on muscle protein turnover at rest, either fed or fasted, we have now examined the possibility of a stimulatory effect of creatine in conjunction with acute resistance exercise. Seven healthy men (body mass index, 23 +/- 2 kg/m2, 21 +/- 1 yr, means +/- SE) performed 20 x 10 repetitions of leg extension-flexion at 75% one-repetition maximum in one leg, on two occasions, 4 wk apart, before and after ingesting 21 g/day creatine for 5 days. The subjects ate approximately 21 g maltodextrin + 6 g protein/h for 3 h postexercise. We measured incorporation of [1-13C]leucine into quadriceps muscle proteins in the rested and exercised legs. Leg protein breakdown (as dilution of [2H5]phenylalanine) was also assessed in the exercised and rested leg postexercise. Creatine supplementation increased muscle total creatine by approximately 21% (P < 0.01). Exercise increased the synthetic rates of myofibrillar and sarcoplasmic proteins by two- to threefold (P < 0.05), and leg phenylalanine balance became more positive, but creatine was without any anabolic effect. SN - 0193-1849 UR - https://www.unboundmedicine.com/medline/citation/12824083/No_effect_of_creatine_supplementation_on_human_myofibrillar_and_sarcoplasmic_protein_synthesis_after_resistance_exercise_ L2 - https://journals.physiology.org/doi/10.1152/ajpendo.00195.2003?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -