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Cholesterol-lowering effect of a theaflavin-enriched green tea extract: a randomized controlled trial.
Arch Intern Med 2003; 163(12):1448-53AI

Abstract

BACKGROUND

Tea consumption has been associated with decreased cardiovascular risk, but potential mechanisms of benefit are ill-defined. While epidemiologic studies suggest that drinking multiple cups of tea per day lowers low-density lipoprotein cholesterol (LDL-C), previous trials of tea drinking and administration of green tea extract have failed to show any impact on lipids and lipoproteins in humans. Our objective was to study the impact of a theaflavin-enriched green tea extract on the lipids and lipoproteins of subjects with mild to moderate hypercholesterolemia.

METHODS

Double-blind, randomized, placebo-controlled, parallel-group trial set in outpatient clinics in 6 urban hospitals in China. A total of 240 men and women 18 years or older on a low-fat diet with mild to moderate hypercholesterolemia were randomly assigned to receive a daily capsule containing theaflavin-enriched green tea extract (375 mg) or placebo for 12 weeks. Main outcome measures were mean percentage changes in total cholesterol, LDL-C, high-density lipoprotein cholesterol (HDL-C), and triglyceride levels compared with baseline.

RESULTS

After 12 weeks, the mean +/- SEM changes from baseline in total cholesterol, LDL-C, HDL-C, and triglyceride levels were -11.3% +/- 0.9% (P =.01), -16.4% +/- 1.1% (P =.01), 2.3% +/- 2.1% (P =.27), and 2.6% +/- 3.5% (P =.47), respectively, in the tea extract group. The mean levels of total cholesterol, LDL-C, HDL-C, and triglycerides did not change significantly in the placebo group. No significant adverse events were observed.

CONCLUSION

The theaflavin-enriched green tea extract we studied is an effective adjunct to a low-saturated-fat diet to reduce LDL-C in hypercholesterolemic adults and is well tolerated.

Authors+Show Affiliations

Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA. david.maron@vanderbilt.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12824094

Citation

Maron, David J., et al. "Cholesterol-lowering Effect of a Theaflavin-enriched Green Tea Extract: a Randomized Controlled Trial." Archives of Internal Medicine, vol. 163, no. 12, 2003, pp. 1448-53.
Maron DJ, Lu GP, Cai NS, et al. Cholesterol-lowering effect of a theaflavin-enriched green tea extract: a randomized controlled trial. Arch Intern Med. 2003;163(12):1448-53.
Maron, D. J., Lu, G. P., Cai, N. S., Wu, Z. G., Li, Y. H., Chen, H., ... Zhao, J. (2003). Cholesterol-lowering effect of a theaflavin-enriched green tea extract: a randomized controlled trial. Archives of Internal Medicine, 163(12), pp. 1448-53.
Maron DJ, et al. Cholesterol-lowering Effect of a Theaflavin-enriched Green Tea Extract: a Randomized Controlled Trial. Arch Intern Med. 2003 Jun 23;163(12):1448-53. PubMed PMID: 12824094.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cholesterol-lowering effect of a theaflavin-enriched green tea extract: a randomized controlled trial. AU - Maron,David J, AU - Lu,Guo Ping, AU - Cai,Nai Sheng, AU - Wu,Zong Gui, AU - Li,Yue Hua, AU - Chen,Hui, AU - Zhu,Jian Qiu, AU - Jin,Xue Juan, AU - Wouters,Bert C, AU - Zhao,Jian, PY - 2003/6/26/pubmed PY - 2003/7/8/medline PY - 2003/6/26/entrez SP - 1448 EP - 53 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 163 IS - 12 N2 - BACKGROUND: Tea consumption has been associated with decreased cardiovascular risk, but potential mechanisms of benefit are ill-defined. While epidemiologic studies suggest that drinking multiple cups of tea per day lowers low-density lipoprotein cholesterol (LDL-C), previous trials of tea drinking and administration of green tea extract have failed to show any impact on lipids and lipoproteins in humans. Our objective was to study the impact of a theaflavin-enriched green tea extract on the lipids and lipoproteins of subjects with mild to moderate hypercholesterolemia. METHODS: Double-blind, randomized, placebo-controlled, parallel-group trial set in outpatient clinics in 6 urban hospitals in China. A total of 240 men and women 18 years or older on a low-fat diet with mild to moderate hypercholesterolemia were randomly assigned to receive a daily capsule containing theaflavin-enriched green tea extract (375 mg) or placebo for 12 weeks. Main outcome measures were mean percentage changes in total cholesterol, LDL-C, high-density lipoprotein cholesterol (HDL-C), and triglyceride levels compared with baseline. RESULTS: After 12 weeks, the mean +/- SEM changes from baseline in total cholesterol, LDL-C, HDL-C, and triglyceride levels were -11.3% +/- 0.9% (P =.01), -16.4% +/- 1.1% (P =.01), 2.3% +/- 2.1% (P =.27), and 2.6% +/- 3.5% (P =.47), respectively, in the tea extract group. The mean levels of total cholesterol, LDL-C, HDL-C, and triglycerides did not change significantly in the placebo group. No significant adverse events were observed. CONCLUSION: The theaflavin-enriched green tea extract we studied is an effective adjunct to a low-saturated-fat diet to reduce LDL-C in hypercholesterolemic adults and is well tolerated. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/12824094/Cholesterol_lowering_effect_of_a_theaflavin_enriched_green_tea_extract:_a_randomized_controlled_trial_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/163/pg/1448 DB - PRIME DP - Unbound Medicine ER -