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Efficacy and safety of sildenafil citrate (Viagra) for the treatment of erectile dysfunction in men in Egypt and South Africa.
Int J Impot Res. 2003 Apr; 15 Suppl 1:S25-9.IJ

Abstract

The efficacy of sildenafil citrate (Viagra), an oral agent for the treatment of erectile dysfunction (ED), has been demonstrated in global studies. This 12-week randomized, double-blind, placebo-controlled, parallel-group, flexible-dose study assessed the efficacy and safety of sildenafil to treat ED in men in Egypt and South Africa. Men with ED of varied etiology were randomized to receive sildenafil 50 mg (n=128) or placebo (n=126); doses could be adjusted to 100 or 25 mg. Questions from the International Index of Erectile Function (IIEF) assessing the ability to achieve (Q3) and maintain (Q4) erections demonstrated a significant improvement with sildenafil compared with placebo (P<0.0001). Improved erections were reported by 74% of patients receiving sildenafil and 27% of those receiving placebo (P<0.0001). Headache, dyspepsia, and flushing were the most common adverse events in sildenafil-treated patients. These results are consistent with clinical trials in other countries. We conclude that sildenafil is an efficacious and well-tolerated treatment for men with ED in Egypt and South Africa.

Authors+Show Affiliations

1Medi Clinic Hospital, Pietermaritzburg, South Africa; currently, GI/GU Unit, Pfizer Global Research and Development, New London, Connecticut 06320, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12825106

Citation

Levinson, I P., et al. "Efficacy and Safety of Sildenafil Citrate (Viagra) for the Treatment of Erectile Dysfunction in Men in Egypt and South Africa." International Journal of Impotence Research, vol. 15 Suppl 1, 2003, pp. S25-9.
Levinson IP, Khalaf IM, Shaeer KZ, et al. Efficacy and safety of sildenafil citrate (Viagra) for the treatment of erectile dysfunction in men in Egypt and South Africa. Int J Impot Res. 2003;15 Suppl 1:S25-9.
Levinson, I. P., Khalaf, I. M., Shaeer, K. Z., & Smart, D. O. (2003). Efficacy and safety of sildenafil citrate (Viagra) for the treatment of erectile dysfunction in men in Egypt and South Africa. International Journal of Impotence Research, 15 Suppl 1, S25-9.
Levinson IP, et al. Efficacy and Safety of Sildenafil Citrate (Viagra) for the Treatment of Erectile Dysfunction in Men in Egypt and South Africa. Int J Impot Res. 2003;15 Suppl 1:S25-9. PubMed PMID: 12825106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy and safety of sildenafil citrate (Viagra) for the treatment of erectile dysfunction in men in Egypt and South Africa. AU - Levinson,I P, AU - Khalaf,I M, AU - Shaeer,K Z M, AU - Smart,D O, PY - 2003/6/26/pubmed PY - 2004/2/27/medline PY - 2003/6/26/entrez SP - S25 EP - 9 JF - International journal of impotence research JO - Int. J. Impot. Res. VL - 15 Suppl 1 N2 - The efficacy of sildenafil citrate (Viagra), an oral agent for the treatment of erectile dysfunction (ED), has been demonstrated in global studies. This 12-week randomized, double-blind, placebo-controlled, parallel-group, flexible-dose study assessed the efficacy and safety of sildenafil to treat ED in men in Egypt and South Africa. Men with ED of varied etiology were randomized to receive sildenafil 50 mg (n=128) or placebo (n=126); doses could be adjusted to 100 or 25 mg. Questions from the International Index of Erectile Function (IIEF) assessing the ability to achieve (Q3) and maintain (Q4) erections demonstrated a significant improvement with sildenafil compared with placebo (P<0.0001). Improved erections were reported by 74% of patients receiving sildenafil and 27% of those receiving placebo (P<0.0001). Headache, dyspepsia, and flushing were the most common adverse events in sildenafil-treated patients. These results are consistent with clinical trials in other countries. We conclude that sildenafil is an efficacious and well-tolerated treatment for men with ED in Egypt and South Africa. SN - 0955-9930 UR - https://www.unboundmedicine.com/medline/citation/12825106/Efficacy_and_safety_of_sildenafil_citrate__Viagra__for_the_treatment_of_erectile_dysfunction_in_men_in_Egypt_and_South_Africa_ L2 - http://dx.doi.org/10.1038/sj.ijir.3900970 DB - PRIME DP - Unbound Medicine ER -