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HLA-B27 subtypes determination in patients with ankylosing spondylitis from Zulia, Venezuela.
Hum Immunol. 2003 Jul; 64(7):745-9.HI

Abstract

To perform an investigation regarding the distribution of the human leukocyte antigen (HLA)-B27 subtypes in the Zulian population with ankylosing spondylitis (AS), 48 unrelated Mestizos, HLA-B27 positive by serology, were studied using the polymerase chain reaction-specific sequence oligonucleotides probe (PCR-SSOP) and specific sequence primers (SSP) to analyze the polymorphism in exons 2 and 3 of the HLA-B27 gene. Only two of eight HLA-B27 subtypes studied (B*2701-B*2708) were found. The distribution of these alleles in the population of patients was: B*2705, 68.8%, and B*2702, 31.2%. B*2705 subtype showed significant association with patients being male. In the healthy controls, the most common subtype was B*2708. These results were compared with frequencies reported in other Mestizo and Spanish populations and showed significant differences, such as a high frequency of B*2702. Such results show that HLA*B2705 and HLA*B2702 are the subtypes most frequently associated with AS in our Mestizo population and suggest a possible protector role for HLA*B2708, which was found only in the healthy population.

Authors+Show Affiliations

University of Zulia, Zulia, Venezuela.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12826378

Citation

Cipriani, Ana, et al. "HLA-B27 Subtypes Determination in Patients With Ankylosing Spondylitis From Zulia, Venezuela." Human Immunology, vol. 64, no. 7, 2003, pp. 745-9.
Cipriani A, Rivera S, Hassanhi M, et al. HLA-B27 subtypes determination in patients with ankylosing spondylitis from Zulia, Venezuela. Hum Immunol. 2003;64(7):745-9.
Cipriani, A., Rivera, S., Hassanhi, M., Márquez, G., Hernández, R., Villalobos, C., & Montiel, M. (2003). HLA-B27 subtypes determination in patients with ankylosing spondylitis from Zulia, Venezuela. Human Immunology, 64(7), 745-9.
Cipriani A, et al. HLA-B27 Subtypes Determination in Patients With Ankylosing Spondylitis From Zulia, Venezuela. Hum Immunol. 2003;64(7):745-9. PubMed PMID: 12826378.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HLA-B27 subtypes determination in patients with ankylosing spondylitis from Zulia, Venezuela. AU - Cipriani,Ana, AU - Rivera,Sergio, AU - Hassanhi,Manzur, AU - Márquez,Georgina, AU - Hernández,Rosaura, AU - Villalobos,Cecilia, AU - Montiel,Milagros, PY - 2003/6/27/pubmed PY - 2004/2/21/medline PY - 2003/6/27/entrez SP - 745 EP - 9 JF - Human immunology JO - Hum Immunol VL - 64 IS - 7 N2 - To perform an investigation regarding the distribution of the human leukocyte antigen (HLA)-B27 subtypes in the Zulian population with ankylosing spondylitis (AS), 48 unrelated Mestizos, HLA-B27 positive by serology, were studied using the polymerase chain reaction-specific sequence oligonucleotides probe (PCR-SSOP) and specific sequence primers (SSP) to analyze the polymorphism in exons 2 and 3 of the HLA-B27 gene. Only two of eight HLA-B27 subtypes studied (B*2701-B*2708) were found. The distribution of these alleles in the population of patients was: B*2705, 68.8%, and B*2702, 31.2%. B*2705 subtype showed significant association with patients being male. In the healthy controls, the most common subtype was B*2708. These results were compared with frequencies reported in other Mestizo and Spanish populations and showed significant differences, such as a high frequency of B*2702. Such results show that HLA*B2705 and HLA*B2702 are the subtypes most frequently associated with AS in our Mestizo population and suggest a possible protector role for HLA*B2708, which was found only in the healthy population. SN - 0198-8859 UR - https://www.unboundmedicine.com/medline/citation/12826378/HLA_B27_subtypes_determination_in_patients_with_ankylosing_spondylitis_from_Zulia_Venezuela_ DB - PRIME DP - Unbound Medicine ER -