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Etiology and pathogenesis of uterine leiomyomas: a review.
Environ Health Perspect 2003; 111(8):1037-54EH

Abstract

Uterine leiomyomas, or fibroids, represent a major public health problem. It is believed that these tumors develop in the majority of American women and become symptomatic in one-third of these women. They are the most frequent indication for hysterectomy in the United States. Although the initiator or initiators of fibroids are unknown, several predisposing factors have been identified, including age (late reproductive years), African-American ethnicity, nulliparity, and obesity. Nonrandom cytogenetic abnormalities have been found in about 40% of tumors examined. Estrogen and progesterone are recognized as promoters of tumor growth, and the potential role of environmental estrogens has only recently been explored. Growth factors with mitogenic activity, such as transforming growth factor- (subscript)3(/subscript), basic fibroblast growth factor, epidermal growth factor, and insulin-like growth factor-I, are elevated in fibroids and may be the effectors of estrogen and progesterone promotion. These data offer clues to the etiology and pathogenesis of this common condition, which we have analyzed and summarized in this review.

Authors+Show Affiliations

Comparative Pathobiology Group, Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12826476

Citation

Flake, Gordon P., et al. "Etiology and Pathogenesis of Uterine Leiomyomas: a Review." Environmental Health Perspectives, vol. 111, no. 8, 2003, pp. 1037-54.
Flake GP, Andersen J, Dixon D. Etiology and pathogenesis of uterine leiomyomas: a review. Environ Health Perspect. 2003;111(8):1037-54.
Flake, G. P., Andersen, J., & Dixon, D. (2003). Etiology and pathogenesis of uterine leiomyomas: a review. Environmental Health Perspectives, 111(8), pp. 1037-54.
Flake GP, Andersen J, Dixon D. Etiology and Pathogenesis of Uterine Leiomyomas: a Review. Environ Health Perspect. 2003;111(8):1037-54. PubMed PMID: 12826476.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Etiology and pathogenesis of uterine leiomyomas: a review. AU - Flake,Gordon P, AU - Andersen,Janet, AU - Dixon,Darlene, PY - 2003/6/27/pubmed PY - 2003/10/18/medline PY - 2003/6/27/entrez SP - 1037 EP - 54 JF - Environmental health perspectives JO - Environ. Health Perspect. VL - 111 IS - 8 N2 - Uterine leiomyomas, or fibroids, represent a major public health problem. It is believed that these tumors develop in the majority of American women and become symptomatic in one-third of these women. They are the most frequent indication for hysterectomy in the United States. Although the initiator or initiators of fibroids are unknown, several predisposing factors have been identified, including age (late reproductive years), African-American ethnicity, nulliparity, and obesity. Nonrandom cytogenetic abnormalities have been found in about 40% of tumors examined. Estrogen and progesterone are recognized as promoters of tumor growth, and the potential role of environmental estrogens has only recently been explored. Growth factors with mitogenic activity, such as transforming growth factor- (subscript)3(/subscript), basic fibroblast growth factor, epidermal growth factor, and insulin-like growth factor-I, are elevated in fibroids and may be the effectors of estrogen and progesterone promotion. These data offer clues to the etiology and pathogenesis of this common condition, which we have analyzed and summarized in this review. SN - 0091-6765 UR - https://www.unboundmedicine.com/medline/citation/12826476/full_citation L2 - https://ehp.niehs.nih.gov/doi/full/10.1289/ehp.5787?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -