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Etiology and pathogenesis of uterine leiomyomas: a review.

Abstract

Uterine leiomyomas, or fibroids, represent a major public health problem. It is believed that these tumors develop in the majority of American women and become symptomatic in one-third of these women. They are the most frequent indication for hysterectomy in the United States. Although the initiator or initiators of fibroids are unknown, several predisposing factors have been identified, including age (late reproductive years), African-American ethnicity, nulliparity, and obesity. Nonrandom cytogenetic abnormalities have been found in about 40% of tumors examined. Estrogen and progesterone are recognized as promoters of tumor growth, and the potential role of environmental estrogens has only recently been explored. Growth factors with mitogenic activity, such as transforming growth factor- (subscript)3(/subscript), basic fibroblast growth factor, epidermal growth factor, and insulin-like growth factor-I, are elevated in fibroids and may be the effectors of estrogen and progesterone promotion. These data offer clues to the etiology and pathogenesis of this common condition, which we have analyzed and summarized in this review.

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  • Authors+Show Affiliations

    ,

    Comparative Pathobiology Group, Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.

    ,

    Source

    Environmental health perspectives 111:8 2003 Jun pg 1037-54

    MeSH

    Age Factors
    Cell Transformation, Neoplastic
    Estrogens
    Female
    Growth Substances
    Humans
    Incidence
    Leiomyoma
    Progesterone
    Receptors, Growth Factor
    Risk Factors
    Uterine Neoplasms

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    12826476

    Citation

    Flake, Gordon P., et al. "Etiology and Pathogenesis of Uterine Leiomyomas: a Review." Environmental Health Perspectives, vol. 111, no. 8, 2003, pp. 1037-54.
    Flake GP, Andersen J, Dixon D. Etiology and pathogenesis of uterine leiomyomas: a review. Environ Health Perspect. 2003;111(8):1037-54.
    Flake, G. P., Andersen, J., & Dixon, D. (2003). Etiology and pathogenesis of uterine leiomyomas: a review. Environmental Health Perspectives, 111(8), pp. 1037-54.
    Flake GP, Andersen J, Dixon D. Etiology and Pathogenesis of Uterine Leiomyomas: a Review. Environ Health Perspect. 2003;111(8):1037-54. PubMed PMID: 12826476.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Etiology and pathogenesis of uterine leiomyomas: a review. AU - Flake,Gordon P, AU - Andersen,Janet, AU - Dixon,Darlene, PY - 2003/6/27/pubmed PY - 2003/10/18/medline PY - 2003/6/27/entrez SP - 1037 EP - 54 JF - Environmental health perspectives JO - Environ. Health Perspect. VL - 111 IS - 8 N2 - Uterine leiomyomas, or fibroids, represent a major public health problem. It is believed that these tumors develop in the majority of American women and become symptomatic in one-third of these women. They are the most frequent indication for hysterectomy in the United States. Although the initiator or initiators of fibroids are unknown, several predisposing factors have been identified, including age (late reproductive years), African-American ethnicity, nulliparity, and obesity. Nonrandom cytogenetic abnormalities have been found in about 40% of tumors examined. Estrogen and progesterone are recognized as promoters of tumor growth, and the potential role of environmental estrogens has only recently been explored. Growth factors with mitogenic activity, such as transforming growth factor- (subscript)3(/subscript), basic fibroblast growth factor, epidermal growth factor, and insulin-like growth factor-I, are elevated in fibroids and may be the effectors of estrogen and progesterone promotion. These data offer clues to the etiology and pathogenesis of this common condition, which we have analyzed and summarized in this review. SN - 0091-6765 UR - https://www.unboundmedicine.com/medline/citation/12826476/full_citation L2 - https://ehp.niehs.nih.gov/doi/full/10.1289/ehp.5787?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -