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Angiotensin-converting enzyme insertion/deletion genotype is associated with the activities of plasma coagulation factor VII and X independent of triglyceride metabolism.
Coron Artery Dis. 2003 Jun; 14(4):285-91.CA

Abstract

BACKGROUND

The D allele of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and coagulation activity play important roles in cardiovascular events, however, the precise association between these two risk factors remains unclear.

METHODS

We identified the ACE I/D genotype and measured the plasma coagulation factor VII and X (FVII and FX) activities and serum lipids in 172 patients (110 men and 62 women, mean age 56.7+/-13.3 years) undergoing coronary angiography.

RESULTS

The frequency of the D allele was significantly higher in those with a history of myocardial infarction (MI) than in those with normal coronary arteries, but there was no significant association between FVII and FX activities and the stage of coronary disease. Plasma coagulation factor VII and FX activities were significantly lower in the DD genotype (n=42) than in the II genotype (n=67, P<0.001 and P<0.001, respectively) or the ID genotype (n=63, P<0.01 and P<0.05, respectively). The association of the ACE D allele with lower activities of FVII and FX was also seen in patients with coronary artery disease (CAD). There was a significant association between serum triglyceride levels with FVII and FX, but not with the ACE I/D genotype.

CONCLUSION

We concluded that the ACE I/D polymorphism may contribute more to the onset of MI than the activities of FVII and FX and that the ACE D allele might be associated with lower plasma activities of FVII and FX. The potential link between ACE I/D polymorphism and the plasma activities of FVII and FX is probably independent of triglyceride metabolism.

Authors+Show Affiliations

Division of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12826927

Citation

Okura, Yoshifumi, et al. "Angiotensin-converting Enzyme Insertion/deletion Genotype Is Associated With the Activities of Plasma Coagulation Factor VII and X Independent of Triglyceride Metabolism." Coronary Artery Disease, vol. 14, no. 4, 2003, pp. 285-91.
Okura Y, Hayashi K, Shingu T, et al. Angiotensin-converting enzyme insertion/deletion genotype is associated with the activities of plasma coagulation factor VII and X independent of triglyceride metabolism. Coron Artery Dis. 2003;14(4):285-91.
Okura, Y., Hayashi, K., Shingu, T., Kuga, Y., Nomura, S., Kajiyama, G., Nakashima, Y., & Saku, K. (2003). Angiotensin-converting enzyme insertion/deletion genotype is associated with the activities of plasma coagulation factor VII and X independent of triglyceride metabolism. Coronary Artery Disease, 14(4), 285-91.
Okura Y, et al. Angiotensin-converting Enzyme Insertion/deletion Genotype Is Associated With the Activities of Plasma Coagulation Factor VII and X Independent of Triglyceride Metabolism. Coron Artery Dis. 2003;14(4):285-91. PubMed PMID: 12826927.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Angiotensin-converting enzyme insertion/deletion genotype is associated with the activities of plasma coagulation factor VII and X independent of triglyceride metabolism. AU - Okura,Yoshifumi, AU - Hayashi,Kozo, AU - Shingu,Tetsuji, AU - Kuga,Yoshio, AU - Nomura,Shuichi, AU - Kajiyama,Goro, AU - Nakashima,Yoshiyuki, AU - Saku,Keijiro, PY - 2003/6/27/pubmed PY - 2003/12/11/medline PY - 2003/6/27/entrez SP - 285 EP - 91 JF - Coronary artery disease JO - Coron Artery Dis VL - 14 IS - 4 N2 - BACKGROUND: The D allele of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and coagulation activity play important roles in cardiovascular events, however, the precise association between these two risk factors remains unclear. METHODS: We identified the ACE I/D genotype and measured the plasma coagulation factor VII and X (FVII and FX) activities and serum lipids in 172 patients (110 men and 62 women, mean age 56.7+/-13.3 years) undergoing coronary angiography. RESULTS: The frequency of the D allele was significantly higher in those with a history of myocardial infarction (MI) than in those with normal coronary arteries, but there was no significant association between FVII and FX activities and the stage of coronary disease. Plasma coagulation factor VII and FX activities were significantly lower in the DD genotype (n=42) than in the II genotype (n=67, P<0.001 and P<0.001, respectively) or the ID genotype (n=63, P<0.01 and P<0.05, respectively). The association of the ACE D allele with lower activities of FVII and FX was also seen in patients with coronary artery disease (CAD). There was a significant association between serum triglyceride levels with FVII and FX, but not with the ACE I/D genotype. CONCLUSION: We concluded that the ACE I/D polymorphism may contribute more to the onset of MI than the activities of FVII and FX and that the ACE D allele might be associated with lower plasma activities of FVII and FX. The potential link between ACE I/D polymorphism and the plasma activities of FVII and FX is probably independent of triglyceride metabolism. SN - 0954-6928 UR - https://www.unboundmedicine.com/medline/citation/12826927/Angiotensin_converting_enzyme_insertion/deletion_genotype_is_associated_with_the_activities_of_plasma_coagulation_factor_VII_and_X_independent_of_triglyceride_metabolism_ L2 - https://doi.org/10.1097/01.mca.0000072847.84236.34 DB - PRIME DP - Unbound Medicine ER -