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Sensitive determination of pethidine in body fluids by gas chromatography-tandem mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jul 15; 792(1):117-21.JC

Abstract

We have presented a simple and sensitive method for determining pethidine, a narcotic analgesic drug in body fluids by gas chromatography-tandem mass spectrometry (GC-MS/MS). Pethidine and 4'-piperidinoacetophenone (internal standard) were extracted from body fluids with Bond Elut C(18) columns; the recoveries were above 85% for both compounds. The calibration curves for blood and urine showed good linearities in the range of 1.25-40 ng/ml. Its detection limits (signal-to-noise ratio=3) were estimated to be approximately 0.5 ng/ml of whole blood and urine.

Authors+Show Affiliations

Department of Legal Medicine, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Toyoake 470-1192, Japan. akishii@fujita-hu.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12829004

Citation

Ishii, Akira, et al. "Sensitive Determination of Pethidine in Body Fluids By Gas Chromatography-tandem Mass Spectrometry." Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, vol. 792, no. 1, 2003, pp. 117-21.
Ishii A, Tanaka M, Kurihara R, et al. Sensitive determination of pethidine in body fluids by gas chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2003;792(1):117-21.
Ishii, A., Tanaka, M., Kurihara, R., Watanabe-Suzuki, K., Kumazawa, T., Seno, H., Suzuki, O., & Katsumata, Y. (2003). Sensitive determination of pethidine in body fluids by gas chromatography-tandem mass spectrometry. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 792(1), 117-21.
Ishii A, et al. Sensitive Determination of Pethidine in Body Fluids By Gas Chromatography-tandem Mass Spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jul 15;792(1):117-21. PubMed PMID: 12829004.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sensitive determination of pethidine in body fluids by gas chromatography-tandem mass spectrometry. AU - Ishii,Akira, AU - Tanaka,Miwa, AU - Kurihara,Rina, AU - Watanabe-Suzuki,Kanako, AU - Kumazawa,Takeshi, AU - Seno,Hiroshi, AU - Suzuki,Osamu, AU - Katsumata,Yoshinao, PY - 2003/6/28/pubmed PY - 2004/3/3/medline PY - 2003/6/28/entrez SP - 117 EP - 21 JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences JO - J Chromatogr B Analyt Technol Biomed Life Sci VL - 792 IS - 1 N2 - We have presented a simple and sensitive method for determining pethidine, a narcotic analgesic drug in body fluids by gas chromatography-tandem mass spectrometry (GC-MS/MS). Pethidine and 4'-piperidinoacetophenone (internal standard) were extracted from body fluids with Bond Elut C(18) columns; the recoveries were above 85% for both compounds. The calibration curves for blood and urine showed good linearities in the range of 1.25-40 ng/ml. Its detection limits (signal-to-noise ratio=3) were estimated to be approximately 0.5 ng/ml of whole blood and urine. SN - 1570-0232 UR - https://www.unboundmedicine.com/medline/citation/12829004/Sensitive_determination_of_pethidine_in_body_fluids_by_gas_chromatography_tandem_mass_spectrometry_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1570023203001326 DB - PRIME DP - Unbound Medicine ER -