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The impact of LH serum concentration on the clinical outcome of IVF cycles in patients receiving two regimens of clomiphene citrate/gonadotrophin/0.25 mg cetrorelix.
Reprod Biomed Online. 2003 Jun; 6(4):421-6.RB

Abstract

Clomiphene citrate treatment with the association of gonadotrophins and the GnRH antagonist cetrorelix 0.25mg was analysed in two different stimulation protocols for IVF. In protocol I, 18 patients were sequentially stimulated with clomiphene citrate and gonadotrophins. In protocol II, 28 patients started the gonadotrophin injections during the clomiphene citrate administration. LH values significantly dropped after the first 0.25 mg cetrorelix injection in both protocols. A total of 22% and 7% of cycles were cancelled in protocols I and II, respectively, because of poor follicular development. The clinical pregnancy rate following embryo transfer was 18.1% in protocol I and 29.1% in protocol II. In two (11.1%) cycles stimulated according to protocol I and in eight (28.5%) cycles from protocol II, premature LH surges occurred. In patients with premature LH surge, significantly fewer metaphase II oocytes were obtained. The clinical pregnancy rate following embryo transfer was 12.5% in patients with surge compared with 29.6% in patients without. LH values were lower before HCG injection in patients who achieved pregnancy in the study cycle. In conclusion, sequential clomiphene citrate and gonadotrophin administration is not recommended for clomiphene citrate/gonadotrophin/cetrorelix 0.25 cycles. Cetrorelix 0.25 mg/day was associated with a high incidence of premature LH surges and premature LH surges were associated with an adverse cycle outcome.

Authors+Show Affiliations

AZ-VUB, Centre for Reproductive Medicine, Dutch-Speaking Free University of Brussels, Laarbeeklaan 101, 1090 Brussels, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

12831586

Citation

Tavaniotou, Asimina, et al. "The Impact of LH Serum Concentration On the Clinical Outcome of IVF Cycles in Patients Receiving Two Regimens of Clomiphene Citrate/gonadotrophin/0.25 Mg Cetrorelix." Reproductive Biomedicine Online, vol. 6, no. 4, 2003, pp. 421-6.
Tavaniotou A, Albano C, Van Steirteghem A, et al. The impact of LH serum concentration on the clinical outcome of IVF cycles in patients receiving two regimens of clomiphene citrate/gonadotrophin/0.25 mg cetrorelix. Reprod Biomed Online. 2003;6(4):421-6.
Tavaniotou, A., Albano, C., Van Steirteghem, A., & Devroey, P. (2003). The impact of LH serum concentration on the clinical outcome of IVF cycles in patients receiving two regimens of clomiphene citrate/gonadotrophin/0.25 mg cetrorelix. Reproductive Biomedicine Online, 6(4), 421-6.
Tavaniotou A, et al. The Impact of LH Serum Concentration On the Clinical Outcome of IVF Cycles in Patients Receiving Two Regimens of Clomiphene Citrate/gonadotrophin/0.25 Mg Cetrorelix. Reprod Biomed Online. 2003;6(4):421-6. PubMed PMID: 12831586.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of LH serum concentration on the clinical outcome of IVF cycles in patients receiving two regimens of clomiphene citrate/gonadotrophin/0.25 mg cetrorelix. AU - Tavaniotou,Asimina, AU - Albano,Carola, AU - Van Steirteghem,André, AU - Devroey,Paul, PY - 2003/7/2/pubmed PY - 2003/8/9/medline PY - 2003/7/2/entrez SP - 421 EP - 6 JF - Reproductive biomedicine online JO - Reprod Biomed Online VL - 6 IS - 4 N2 - Clomiphene citrate treatment with the association of gonadotrophins and the GnRH antagonist cetrorelix 0.25mg was analysed in two different stimulation protocols for IVF. In protocol I, 18 patients were sequentially stimulated with clomiphene citrate and gonadotrophins. In protocol II, 28 patients started the gonadotrophin injections during the clomiphene citrate administration. LH values significantly dropped after the first 0.25 mg cetrorelix injection in both protocols. A total of 22% and 7% of cycles were cancelled in protocols I and II, respectively, because of poor follicular development. The clinical pregnancy rate following embryo transfer was 18.1% in protocol I and 29.1% in protocol II. In two (11.1%) cycles stimulated according to protocol I and in eight (28.5%) cycles from protocol II, premature LH surges occurred. In patients with premature LH surge, significantly fewer metaphase II oocytes were obtained. The clinical pregnancy rate following embryo transfer was 12.5% in patients with surge compared with 29.6% in patients without. LH values were lower before HCG injection in patients who achieved pregnancy in the study cycle. In conclusion, sequential clomiphene citrate and gonadotrophin administration is not recommended for clomiphene citrate/gonadotrophin/cetrorelix 0.25 cycles. Cetrorelix 0.25 mg/day was associated with a high incidence of premature LH surges and premature LH surges were associated with an adverse cycle outcome. SN - 1472-6483 UR - https://www.unboundmedicine.com/medline/citation/12831586/The_impact_of_LH_serum_concentration_on_the_clinical_outcome_of_IVF_cycles_in_patients_receiving_two_regimens_of_clomiphene_citrate/gonadotrophin/0_25_mg_cetrorelix_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1472-6483(10)62161-X DB - PRIME DP - Unbound Medicine ER -