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Single dose application of cetrorelix in combination with clomiphene for friendly IVF: results of a feasibility study.
Reprod Biomed Online. 2003 Jun; 6(4):444-7.RB

Abstract

A prospective randomized feasibility study was carried out on 10 patients undergoing IVF treatment using a single-dose LHRH antagonist protocol (cetrorelix, Cetrotide) with clomiphene citrate in combination with either human menopausal gonadotrophin (HMG) (n = 5) or recombinant human FSH (rFSH) (n = 5). Both treatment-groups, HMG and rFSH, were comparable with regard to age (33.2 +/- 2.6 versus 34.4 +/- 4.0 years) BMI (23.2 +/- 2.6 versus 22.7 +/- 1.6) and cause of infertility. They yielded comparable results concerning gonadotrophin dose (19.8 +/- 8.7 versus 17.0 +/- 8.9), stimulation days (6.5 +/- 2.0 versus 5.8 +/- 1.9) and live births (one versus two). No premature LH surge (LH >10 IU/ml and progesterone >1 ng/ml) occurred. The overall baby take-home rate was 30%. In a small number of patients, cetrorelix could be shown to effectively prevent premature LH surges in stimulation protocols combining clomiphene with gonadotrophins with an excellent baby take-home rate per started cycle of 30%.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Hôpital Antoine Béclère, 157 Rue de la Porte de Trivaux, 92141 Clamart, France. joergbengel@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

12831591

Citation

Engel, J B., et al. "Single Dose Application of Cetrorelix in Combination With Clomiphene for Friendly IVF: Results of a Feasibility Study." Reproductive Biomedicine Online, vol. 6, no. 4, 2003, pp. 444-7.
Engel JB, Olivennes F, Fanchin R, et al. Single dose application of cetrorelix in combination with clomiphene for friendly IVF: results of a feasibility study. Reprod Biomed Online. 2003;6(4):444-7.
Engel, J. B., Olivennes, F., Fanchin, R., Frydman, N., Le D슩, A., Blanchet, V., & Frydman, R. (2003). Single dose application of cetrorelix in combination with clomiphene for friendly IVF: results of a feasibility study. Reproductive Biomedicine Online, 6(4), 444-7.
Engel JB, et al. Single Dose Application of Cetrorelix in Combination With Clomiphene for Friendly IVF: Results of a Feasibility Study. Reprod Biomed Online. 2003;6(4):444-7. PubMed PMID: 12831591.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Single dose application of cetrorelix in combination with clomiphene for friendly IVF: results of a feasibility study. AU - Engel,J B, AU - Olivennes,F, AU - Fanchin,R, AU - Frydman,N, AU - Le D슩,A, AU - Blanchet,V, AU - Frydman,R, PY - 2003/7/2/pubmed PY - 2003/8/9/medline PY - 2003/7/2/entrez SP - 444 EP - 7 JF - Reproductive biomedicine online JO - Reprod Biomed Online VL - 6 IS - 4 N2 - A prospective randomized feasibility study was carried out on 10 patients undergoing IVF treatment using a single-dose LHRH antagonist protocol (cetrorelix, Cetrotide) with clomiphene citrate in combination with either human menopausal gonadotrophin (HMG) (n = 5) or recombinant human FSH (rFSH) (n = 5). Both treatment-groups, HMG and rFSH, were comparable with regard to age (33.2 +/- 2.6 versus 34.4 +/- 4.0 years) BMI (23.2 +/- 2.6 versus 22.7 +/- 1.6) and cause of infertility. They yielded comparable results concerning gonadotrophin dose (19.8 +/- 8.7 versus 17.0 +/- 8.9), stimulation days (6.5 +/- 2.0 versus 5.8 +/- 1.9) and live births (one versus two). No premature LH surge (LH >10 IU/ml and progesterone >1 ng/ml) occurred. The overall baby take-home rate was 30%. In a small number of patients, cetrorelix could be shown to effectively prevent premature LH surges in stimulation protocols combining clomiphene with gonadotrophins with an excellent baby take-home rate per started cycle of 30%. SN - 1472-6483 UR - https://www.unboundmedicine.com/medline/citation/12831591/Single_dose_application_of_cetrorelix_in_combination_with_clomiphene_for_friendly_IVF:_results_of_a_feasibility_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1472-6483(10)62165-7 DB - PRIME DP - Unbound Medicine ER -