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Complex effects of different green tea catechins on human platelets.
FEBS Lett 2003; 546(2-3):265-70FL

Abstract

Epigallocatechin gallate (EGCG), a major component of green tea, has been previously shown to inhibit platelet aggregation. The effects of other green tea catechins on platelet function are not known. Pre-incubation with EGCG concentration-dependently inhibited thrombin-induced aggregation and phosphorylation of p38 mitogen-activated protein kinase and extracellular signal-regulated kinases-1/2. In contrast EGCG stimulated tyrosine phosphorylation of platelet proteins, including Syk and SLP-76 but inhibited phosphorylation of focal adhesion kinase. Other catechins did not inhibit platelet aggregation. Interestingly, when EGCG was added to stirred platelets, a tyrosine kinase-dependent stimulation of platelet aggregation was observed. The two other catechins containing a galloyl group in the 3' position (catechin gallate, epicatechin gallate) also stimulated platelet aggregation, while catechins without a galloyl group (catechin, epicatechin) or the catechin with a galloyl group in the 2' position (epigallocatechin) did not.

Authors+Show Affiliations

Institut für Pharmakologie und Klinische Pharmakologie, Universitätsklinikum Düsseldorf, Moorenstr 5, D-40225 Düsseldorf, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12832052

Citation

Lill, Gereon, et al. "Complex Effects of Different Green Tea Catechins On Human Platelets." FEBS Letters, vol. 546, no. 2-3, 2003, pp. 265-70.
Lill G, Voit S, Schrör K, et al. Complex effects of different green tea catechins on human platelets. FEBS Lett. 2003;546(2-3):265-70.
Lill, G., Voit, S., Schrör, K., & Weber, A. A. (2003). Complex effects of different green tea catechins on human platelets. FEBS Letters, 546(2-3), pp. 265-70.
Lill G, et al. Complex Effects of Different Green Tea Catechins On Human Platelets. FEBS Lett. 2003 Jul 10;546(2-3):265-70. PubMed PMID: 12832052.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Complex effects of different green tea catechins on human platelets. AU - Lill,Gereon, AU - Voit,Simone, AU - Schrör,Karsten, AU - Weber,Artur-Aron, PY - 2003/7/2/pubmed PY - 2003/8/2/medline PY - 2003/7/2/entrez SP - 265 EP - 70 JF - FEBS letters JO - FEBS Lett. VL - 546 IS - 2-3 N2 - Epigallocatechin gallate (EGCG), a major component of green tea, has been previously shown to inhibit platelet aggregation. The effects of other green tea catechins on platelet function are not known. Pre-incubation with EGCG concentration-dependently inhibited thrombin-induced aggregation and phosphorylation of p38 mitogen-activated protein kinase and extracellular signal-regulated kinases-1/2. In contrast EGCG stimulated tyrosine phosphorylation of platelet proteins, including Syk and SLP-76 but inhibited phosphorylation of focal adhesion kinase. Other catechins did not inhibit platelet aggregation. Interestingly, when EGCG was added to stirred platelets, a tyrosine kinase-dependent stimulation of platelet aggregation was observed. The two other catechins containing a galloyl group in the 3' position (catechin gallate, epicatechin gallate) also stimulated platelet aggregation, while catechins without a galloyl group (catechin, epicatechin) or the catechin with a galloyl group in the 2' position (epigallocatechin) did not. SN - 0014-5793 UR - https://www.unboundmedicine.com/medline/citation/12832052/Complex_effects_of_different_green_tea_catechins_on_human_platelets_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014579303005994 DB - PRIME DP - Unbound Medicine ER -