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Complex effects of different green tea catechins on human platelets.

Abstract

Epigallocatechin gallate (EGCG), a major component of green tea, has been previously shown to inhibit platelet aggregation. The effects of other green tea catechins on platelet function are not known. Pre-incubation with EGCG concentration-dependently inhibited thrombin-induced aggregation and phosphorylation of p38 mitogen-activated protein kinase and extracellular signal-regulated kinases-1/2. In contrast EGCG stimulated tyrosine phosphorylation of platelet proteins, including Syk and SLP-76 but inhibited phosphorylation of focal adhesion kinase. Other catechins did not inhibit platelet aggregation. Interestingly, when EGCG was added to stirred platelets, a tyrosine kinase-dependent stimulation of platelet aggregation was observed. The two other catechins containing a galloyl group in the 3' position (catechin gallate, epicatechin gallate) also stimulated platelet aggregation, while catechins without a galloyl group (catechin, epicatechin) or the catechin with a galloyl group in the 2' position (epigallocatechin) did not.

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  • Authors+Show Affiliations

    ,

    Institut für Pharmakologie und Klinische Pharmakologie, Universitätsklinikum Düsseldorf, Moorenstr 5, D-40225 Düsseldorf, Germany.

    , ,

    Source

    FEBS letters 546:2-3 2003 Jul 10 pg 265-70

    MeSH

    Blood Platelets
    Catechin
    Flow Cytometry
    Humans
    Phosphorylation
    Platelet Aggregation
    Signal Transduction
    Tea
    Thrombin
    Tyrosine

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    12832052

    Citation

    Lill, Gereon, et al. "Complex Effects of Different Green Tea Catechins On Human Platelets." FEBS Letters, vol. 546, no. 2-3, 2003, pp. 265-70.
    Lill G, Voit S, Schrör K, et al. Complex effects of different green tea catechins on human platelets. FEBS Lett. 2003;546(2-3):265-70.
    Lill, G., Voit, S., Schrör, K., & Weber, A. A. (2003). Complex effects of different green tea catechins on human platelets. FEBS Letters, 546(2-3), pp. 265-70.
    Lill G, et al. Complex Effects of Different Green Tea Catechins On Human Platelets. FEBS Lett. 2003 Jul 10;546(2-3):265-70. PubMed PMID: 12832052.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Complex effects of different green tea catechins on human platelets. AU - Lill,Gereon, AU - Voit,Simone, AU - Schrör,Karsten, AU - Weber,Artur-Aron, PY - 2003/7/2/pubmed PY - 2003/8/2/medline PY - 2003/7/2/entrez SP - 265 EP - 70 JF - FEBS letters JO - FEBS Lett. VL - 546 IS - 2-3 N2 - Epigallocatechin gallate (EGCG), a major component of green tea, has been previously shown to inhibit platelet aggregation. The effects of other green tea catechins on platelet function are not known. Pre-incubation with EGCG concentration-dependently inhibited thrombin-induced aggregation and phosphorylation of p38 mitogen-activated protein kinase and extracellular signal-regulated kinases-1/2. In contrast EGCG stimulated tyrosine phosphorylation of platelet proteins, including Syk and SLP-76 but inhibited phosphorylation of focal adhesion kinase. Other catechins did not inhibit platelet aggregation. Interestingly, when EGCG was added to stirred platelets, a tyrosine kinase-dependent stimulation of platelet aggregation was observed. The two other catechins containing a galloyl group in the 3' position (catechin gallate, epicatechin gallate) also stimulated platelet aggregation, while catechins without a galloyl group (catechin, epicatechin) or the catechin with a galloyl group in the 2' position (epigallocatechin) did not. SN - 0014-5793 UR - https://www.unboundmedicine.com/medline/citation/12832052/Complex_effects_of_different_green_tea_catechins_on_human_platelets_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014579303005994 DB - PRIME DP - Unbound Medicine ER -