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Efficacy of atypical antipsychotics in mood disorders.
J Clin Psychopharmacol. 2003 Jun; 23(3 Suppl 1):S9-14.JC

Abstract

Lithium and valproate are well recognized as mood-stabilizing medications. However, a significant number of patients with bipolar disorder do not respond to or cannot tolerate the side effects of these drugs. As a result, a search for safer and more effective mood stabilizers for the treatment of bipolar disorder is ongoing. Antipsychotic medications have long been used as adjunctive therapy in combination with mood-stabilizing medications. Although conventional neuroleptics (also known as typical antipsychotics) such as haloperidol or chlorpromazine are effective antimanic agents, they do not appear to have any efficacy in treating comorbid depressive symptoms. Furthermore, typical antipsychotics are associated with a number of well-known side effects, such as extrapyramidal symptoms and tardive dyskinesia. Mood-stabilizing effects have recently been reported for a number of newer "atypical" antipsychotics that have a broader spectrum of efficacy and better safety profiles than the typical antipsychotics. The results of several clinical trials suggest that atypical antipsychotics, including risperidone, olanzapine, ziprasidone, and quetiapine, are effective for the treatment of acute mania, and open-label studies suggest that atypical antipsychotics may have long-term mood-stabilizing effects.

Authors+Show Affiliations

University of British Columbia, Vancouver, Canada. yatham@interchange.ubc.ca

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12832944

Citation

Yatham, Lakshmi N.. "Efficacy of Atypical Antipsychotics in Mood Disorders." Journal of Clinical Psychopharmacology, vol. 23, no. 3 Suppl 1, 2003, pp. S9-14.
Yatham LN. Efficacy of atypical antipsychotics in mood disorders. J Clin Psychopharmacol. 2003;23(3 Suppl 1):S9-14.
Yatham, L. N. (2003). Efficacy of atypical antipsychotics in mood disorders. Journal of Clinical Psychopharmacology, 23(3 Suppl 1), S9-14.
Yatham LN. Efficacy of Atypical Antipsychotics in Mood Disorders. J Clin Psychopharmacol. 2003;23(3 Suppl 1):S9-14. PubMed PMID: 12832944.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of atypical antipsychotics in mood disorders. A1 - Yatham,Lakshmi N, PY - 2003/7/2/pubmed PY - 2003/10/22/medline PY - 2003/7/2/entrez SP - S9 EP - 14 JF - Journal of clinical psychopharmacology JO - J Clin Psychopharmacol VL - 23 IS - 3 Suppl 1 N2 - Lithium and valproate are well recognized as mood-stabilizing medications. However, a significant number of patients with bipolar disorder do not respond to or cannot tolerate the side effects of these drugs. As a result, a search for safer and more effective mood stabilizers for the treatment of bipolar disorder is ongoing. Antipsychotic medications have long been used as adjunctive therapy in combination with mood-stabilizing medications. Although conventional neuroleptics (also known as typical antipsychotics) such as haloperidol or chlorpromazine are effective antimanic agents, they do not appear to have any efficacy in treating comorbid depressive symptoms. Furthermore, typical antipsychotics are associated with a number of well-known side effects, such as extrapyramidal symptoms and tardive dyskinesia. Mood-stabilizing effects have recently been reported for a number of newer "atypical" antipsychotics that have a broader spectrum of efficacy and better safety profiles than the typical antipsychotics. The results of several clinical trials suggest that atypical antipsychotics, including risperidone, olanzapine, ziprasidone, and quetiapine, are effective for the treatment of acute mania, and open-label studies suggest that atypical antipsychotics may have long-term mood-stabilizing effects. SN - 0271-0749 UR - https://www.unboundmedicine.com/medline/citation/12832944/Efficacy_of_atypical_antipsychotics_in_mood_disorders_ L2 - https://doi.org/10.1097/01.jcp.0000084036.22282.ea DB - PRIME DP - Unbound Medicine ER -