Tags

Type your tag names separated by a space and hit enter

Clobetasol propionate 0.05% under occlusion in the treatment of alopecia totalis/universalis.
J Am Acad Dermatol. 2003 Jul; 49(1):96-8.JA

Abstract

BACKGROUND

Efficacy of topical steroids in alopecia areata is still discussed.

OBJECTIVE

The purpose of this study was to evaluate the efficacy of clobetasol propionate 0.05% ointment under occlusion in 28 patients with alopecia areata totalis (AT) or AT/alopecia universalis.

METHODS

A total of 28 patients were instructed to apply 2.5 g of clobetasol propionate to the right side of the scalp every night under occlusion with a plastic film. Treatment was performed 6 days a week for 6 months. When regrowth of terminal hair occurred, treatment was extended over the entire scalp. All patients were followed up for another 6 months.

RESULTS

Of the 28 patients included in the study, 8 were treated successfully (28.5%). Regrowth of terminal hair began on the treated side 6 to 14 weeks after the start of treatment. Of these 8 patients, 3 had a relapse and were not able to maintain hair regrowth.

CONCLUSION

Our study shows that clobetasol propionate 0.05% under occlusion is effective in inducing hair regrowth in patients with AT or AT/alopecia universalis. Occurrence of hair regrowth only on the treated half of the scalp clearly shows that efficacy of treatment is a result of a local and not systemic effect of the drug. Although only 17.8% of patients had long-term benefit by treatment, our results were obtained in a population of patients with severe and refractory forms of the disease.

Authors+Show Affiliations

Department of Dermatology, University of Bologna, Italy. tosti@almadns.unibo.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

12833016

Citation

Tosti, Antonella, et al. "Clobetasol Propionate 0.05% Under Occlusion in the Treatment of Alopecia Totalis/universalis." Journal of the American Academy of Dermatology, vol. 49, no. 1, 2003, pp. 96-8.
Tosti A, Piraccini BM, Pazzaglia M, et al. Clobetasol propionate 0.05% under occlusion in the treatment of alopecia totalis/universalis. J Am Acad Dermatol. 2003;49(1):96-8.
Tosti, A., Piraccini, B. M., Pazzaglia, M., & Vincenzi, C. (2003). Clobetasol propionate 0.05% under occlusion in the treatment of alopecia totalis/universalis. Journal of the American Academy of Dermatology, 49(1), 96-8.
Tosti A, et al. Clobetasol Propionate 0.05% Under Occlusion in the Treatment of Alopecia Totalis/universalis. J Am Acad Dermatol. 2003;49(1):96-8. PubMed PMID: 12833016.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clobetasol propionate 0.05% under occlusion in the treatment of alopecia totalis/universalis. AU - Tosti,Antonella, AU - Piraccini,Bianca Maria, AU - Pazzaglia,Massimiliano, AU - Vincenzi,Colombina, PY - 2003/7/2/pubmed PY - 2003/8/2/medline PY - 2003/7/2/entrez SP - 96 EP - 8 JF - Journal of the American Academy of Dermatology JO - J. Am. Acad. Dermatol. VL - 49 IS - 1 N2 - BACKGROUND: Efficacy of topical steroids in alopecia areata is still discussed. OBJECTIVE: The purpose of this study was to evaluate the efficacy of clobetasol propionate 0.05% ointment under occlusion in 28 patients with alopecia areata totalis (AT) or AT/alopecia universalis. METHODS: A total of 28 patients were instructed to apply 2.5 g of clobetasol propionate to the right side of the scalp every night under occlusion with a plastic film. Treatment was performed 6 days a week for 6 months. When regrowth of terminal hair occurred, treatment was extended over the entire scalp. All patients were followed up for another 6 months. RESULTS: Of the 28 patients included in the study, 8 were treated successfully (28.5%). Regrowth of terminal hair began on the treated side 6 to 14 weeks after the start of treatment. Of these 8 patients, 3 had a relapse and were not able to maintain hair regrowth. CONCLUSION: Our study shows that clobetasol propionate 0.05% under occlusion is effective in inducing hair regrowth in patients with AT or AT/alopecia universalis. Occurrence of hair regrowth only on the treated half of the scalp clearly shows that efficacy of treatment is a result of a local and not systemic effect of the drug. Although only 17.8% of patients had long-term benefit by treatment, our results were obtained in a population of patients with severe and refractory forms of the disease. SN - 0190-9622 UR - https://www.unboundmedicine.com/medline/citation/12833016/Clobetasol_propionate_0_05_under_occlusion_in_the_treatment_of_alopecia_totalis/universalis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190962203007795 DB - PRIME DP - Unbound Medicine ER -