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[Obstetric complications and risk of schizophrenia. An association appears undisputed, yet mechanisms are still unknown].
Lakartidningen 2003; 100(22):1974-9L

Abstract

This paper reviews the literature on obstetric complications (e.g. premature births and hypoxia at birth) and the later development of schizophrenia. Some forty studies and two meta-analyses are summarised concerning methods and results. The balance of evidence today supports an association between obstetric complications at different points of time: during foetal life, delivery, as well as during neonatal life. This is supported by other studies of early life risk factors, e.g. infections, maternal stress and famine. Presuming there is a causal relationship, the results may support the view that various underlying "mechanisms" may be associated with schizophrenia. On the other hand this does not exclude a final common pathway. One candidate, among others, is the deleterious effects of hypoxia, hypoglycaemia, and hyperbilirubinaemia on the NMDA-receptors. To further understand how the factors are related, the statistical models in epidemiological research have to be improved and co-operation with other disciplines such as neuropathology and genetics is a necessity.

Authors+Show Affiliations

christina.dalman@smd.sll.se

Pub Type(s)

English Abstract
Journal Article
Review

Language

swe

PubMed ID

12833729

Citation

Dalman, Christina. "[Obstetric Complications and Risk of Schizophrenia. an Association Appears Undisputed, yet Mechanisms Are Still Unknown]." Lakartidningen, vol. 100, no. 22, 2003, pp. 1974-9.
Dalman C. [Obstetric complications and risk of schizophrenia. An association appears undisputed, yet mechanisms are still unknown]. Lakartidningen. 2003;100(22):1974-9.
Dalman, C. (2003). [Obstetric complications and risk of schizophrenia. An association appears undisputed, yet mechanisms are still unknown]. Lakartidningen, 100(22), pp. 1974-9.
Dalman C. [Obstetric Complications and Risk of Schizophrenia. an Association Appears Undisputed, yet Mechanisms Are Still Unknown]. Lakartidningen. 2003 May 28;100(22):1974-9. PubMed PMID: 12833729.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Obstetric complications and risk of schizophrenia. An association appears undisputed, yet mechanisms are still unknown]. A1 - Dalman,Christina, PY - 2003/7/2/pubmed PY - 2003/8/6/medline PY - 2003/7/2/entrez SP - 1974 EP - 9 JF - Lakartidningen JO - Lakartidningen VL - 100 IS - 22 N2 - This paper reviews the literature on obstetric complications (e.g. premature births and hypoxia at birth) and the later development of schizophrenia. Some forty studies and two meta-analyses are summarised concerning methods and results. The balance of evidence today supports an association between obstetric complications at different points of time: during foetal life, delivery, as well as during neonatal life. This is supported by other studies of early life risk factors, e.g. infections, maternal stress and famine. Presuming there is a causal relationship, the results may support the view that various underlying "mechanisms" may be associated with schizophrenia. On the other hand this does not exclude a final common pathway. One candidate, among others, is the deleterious effects of hypoxia, hypoglycaemia, and hyperbilirubinaemia on the NMDA-receptors. To further understand how the factors are related, the statistical models in epidemiological research have to be improved and co-operation with other disciplines such as neuropathology and genetics is a necessity. SN - 0023-7205 UR - https://www.unboundmedicine.com/medline/citation/12833729/[Obstetric_complications_and_risk_of_schizophrenia__An_association_appears_undisputed_yet_mechanisms_are_still_unknown]_ L2 - http://www.diseaseinfosearch.org/result/6442 DB - PRIME DP - Unbound Medicine ER -