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[Three patients with Parkinson's disease whose therapeutic levels were successfully improved after administration of quetiapine for suppression of psychosis].
No To Shinkei. 2003 May; 55(5):413-7.NT

Abstract

Psychosis characterized by hallucination or delusion, which occurs during drug therapy of parkinsonian patients, is one of the limiting factors for the control of motor symptoms or complications. In the present study, we encountered three patients with Parkinson's disease (PD) at advanced stages; all three patients had severe psychosis and severe wearing-off phenomenon and one had severe orthostatic hypotension. Their psychotic symptoms were successfully treated by administration of quetiapine, resulting in the favorable control of motor fluctuations and elevation of therapeutic levels unless any aggravation of parkinsonism occurs. Although the measure against drug-induced psychosis is principally a reduction of the doses or withdrawal of causative drugs, the effective use of antipsychotic drugs, such as quetiapine, is helpful to suppress psychosis and allow the patient to adjust to antiparkinsonian drugs for the control of symptoms other than psychosis.

Authors+Show Affiliations

Department of Neurology, Wakayama Medical University, 811-1 Kimiidera, Wakayama-City, Wakayama 641-8510, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

jpn

PubMed ID

12833883

Citation

Kodama, Rieko, et al. "[Three Patients With Parkinson's Disease Whose Therapeutic Levels Were Successfully Improved After Administration of Quetiapine for Suppression of Psychosis]." No to Shinkei = Brain and Nerve, vol. 55, no. 5, 2003, pp. 413-7.
Kodama R, Morita S, Miwa H, et al. [Three patients with Parkinson's disease whose therapeutic levels were successfully improved after administration of quetiapine for suppression of psychosis]. No To Shinkei. 2003;55(5):413-7.
Kodama, R., Morita, S., Miwa, H., & Kondo, T. (2003). [Three patients with Parkinson's disease whose therapeutic levels were successfully improved after administration of quetiapine for suppression of psychosis]. No to Shinkei = Brain and Nerve, 55(5), 413-7.
Kodama R, et al. [Three Patients With Parkinson's Disease Whose Therapeutic Levels Were Successfully Improved After Administration of Quetiapine for Suppression of Psychosis]. No To Shinkei. 2003;55(5):413-7. PubMed PMID: 12833883.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Three patients with Parkinson's disease whose therapeutic levels were successfully improved after administration of quetiapine for suppression of psychosis]. AU - Kodama,Rieko, AU - Morita,Shuhei, AU - Miwa,Hideto, AU - Kondo,Tomoyoshi, PY - 2003/7/2/pubmed PY - 2003/9/3/medline PY - 2003/7/2/entrez SP - 413 EP - 7 JF - No to shinkei = Brain and nerve JO - No To Shinkei VL - 55 IS - 5 N2 - Psychosis characterized by hallucination or delusion, which occurs during drug therapy of parkinsonian patients, is one of the limiting factors for the control of motor symptoms or complications. In the present study, we encountered three patients with Parkinson's disease (PD) at advanced stages; all three patients had severe psychosis and severe wearing-off phenomenon and one had severe orthostatic hypotension. Their psychotic symptoms were successfully treated by administration of quetiapine, resulting in the favorable control of motor fluctuations and elevation of therapeutic levels unless any aggravation of parkinsonism occurs. Although the measure against drug-induced psychosis is principally a reduction of the doses or withdrawal of causative drugs, the effective use of antipsychotic drugs, such as quetiapine, is helpful to suppress psychosis and allow the patient to adjust to antiparkinsonian drugs for the control of symptoms other than psychosis. SN - 0006-8969 UR - https://www.unboundmedicine.com/medline/citation/12833883/[Three_patients_with_Parkinson's_disease_whose_therapeutic_levels_were_successfully_improved_after_administration_of_quetiapine_for_suppression_of_psychosis]_ L2 - https://webview.isho.jp/openurl?rft.genre=article&rft.issn=0006-8969&rft.volume=55&rft.issue=5&rft.spage=413 DB - PRIME DP - Unbound Medicine ER -