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Fenfluramine and 5-hydroxytryptamine. Part 2: Involvement of brain 5-hydroxytryptamine in the anorectic activity of fenfluramine.
Arzneimittelforschung. 1975 Nov; 25(11):1758-62.A

Abstract

As it is well-known, fenfluramine produces anorexia and decrease in brain 5-hydroxytryptamine (5-HT). As it has been suggested that the anorectic effect of fenfluramine may be due to a release of brain 5-HT, we have examined the influence of several drugs active on 5-HT mechanisms and metabolism, on the anorexigenic activity of fenfluramine. These studies were made in relationship with the depletion of 5-HT levels and the concentration of brain fenfluramine or m-trifluoromethyl-isopropylamine. The results have confirmed the involvement of a tryptaminergic mechanism in fenfluramine anorexia and suggest the hypothesis that fenfluramine itself can interfere with the serotoninergic system in the brain (stimulation of tryptaminergic neurons directly).

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

128366

Citation

Duhault, J, et al. "Fenfluramine and 5-hydroxytryptamine. Part 2: Involvement of Brain 5-hydroxytryptamine in the Anorectic Activity of Fenfluramine." Arzneimittel-Forschung, vol. 25, no. 11, 1975, pp. 1758-62.
Duhault J, Boulanger M, Voisin C, et al. Fenfluramine and 5-hydroxytryptamine. Part 2: Involvement of brain 5-hydroxytryptamine in the anorectic activity of fenfluramine. Arzneimittelforschung. 1975;25(11):1758-62.
Duhault, J., Boulanger, M., Voisin, C., Malen, C., & Schmitt, H. (1975). Fenfluramine and 5-hydroxytryptamine. Part 2: Involvement of brain 5-hydroxytryptamine in the anorectic activity of fenfluramine. Arzneimittel-Forschung, 25(11), 1758-62.
Duhault J, et al. Fenfluramine and 5-hydroxytryptamine. Part 2: Involvement of Brain 5-hydroxytryptamine in the Anorectic Activity of Fenfluramine. Arzneimittelforschung. 1975;25(11):1758-62. PubMed PMID: 128366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fenfluramine and 5-hydroxytryptamine. Part 2: Involvement of brain 5-hydroxytryptamine in the anorectic activity of fenfluramine. AU - Duhault,J, AU - Boulanger,M, AU - Voisin,C, AU - Malen,C, AU - Schmitt,H, PY - 1975/11/1/pubmed PY - 1975/11/1/medline PY - 1975/11/1/entrez SP - 1758 EP - 62 JF - Arzneimittel-Forschung JO - Arzneimittelforschung VL - 25 IS - 11 N2 - As it is well-known, fenfluramine produces anorexia and decrease in brain 5-hydroxytryptamine (5-HT). As it has been suggested that the anorectic effect of fenfluramine may be due to a release of brain 5-HT, we have examined the influence of several drugs active on 5-HT mechanisms and metabolism, on the anorexigenic activity of fenfluramine. These studies were made in relationship with the depletion of 5-HT levels and the concentration of brain fenfluramine or m-trifluoromethyl-isopropylamine. The results have confirmed the involvement of a tryptaminergic mechanism in fenfluramine anorexia and suggest the hypothesis that fenfluramine itself can interfere with the serotoninergic system in the brain (stimulation of tryptaminergic neurons directly). SN - 0004-4172 UR - https://www.unboundmedicine.com/medline/citation/128366/Fenfluramine_and_5_hydroxytryptamine__Part_2:_Involvement_of_brain_5_hydroxytryptamine_in_the_anorectic_activity_of_fenfluramine_ L2 - https://antibodies.cancer.gov/detail/CPTC-HLA-B-1 DB - PRIME DP - Unbound Medicine ER -