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Prevention of immunosuppression by sunscreens in humans is unrelated to protection from erythema and dependent on protection from ultraviolet a in the face of constant ultraviolet B protection.
J Invest Dermatol. 2003 Jul; 121(1):184-90.JI

Abstract

Sunscreens have been advocated as an important means of preventing skin cancer. Ultraviolet radiation induced immunosuppression is recognized as an important event in skin cancer development, yet the effectiveness of sunscreens in protecting the human immune system from ultraviolet radiation (i.e. ultraviolet radiation) is still unclear. The only currently accepted method of sunscreen rating is the sun protection factor system based on the prevention of erythema. We determined immune protection factors for six commercially available sunscreens using a nickel contact hypersensitivity model in humans. Both sun protection factor and immune protection factor testing was performed using the same solar simulated ultraviolet radiation source and dose-responses were used to determine endpoints both with and without sunscreens. We found that the immune protection factor did not correlate with the sun protection factor; however, immune protection factor was significantly correlated to the ultraviolet A protective capability of the sunscreens, indicating that sunscreen protection from ultraviolet A is important for the prevention of ultraviolet immunosuppression, when there is constant ultraviolet B protection. We recommend that sunscreens should be rated against their immune protective capability to provide a better indication of their ability to protect against skin cancer.

Authors+Show Affiliations

Poon TS
Department of Medicine (Dermatology), Melanoma and Skin Cancer Research Institute, Sydney Cancer Centre, Royal Prince Alfred Hospital at the University of Sydney, Australia.
Barnetson RS
No affiliation info available
Halliday GM
No affiliation info available

MeSH

AdolescentAdultAgedDermatitis, Allergic ContactDose-Response Relationship, RadiationErythemaHumansImmunocompetenceMiddle AgedNickelSkinSkin NeoplasmsSunburnSunscreening AgentsUltraviolet Rays

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12839580

Citation

Poon, Terence S C., et al. "Prevention of Immunosuppression By Sunscreens in Humans Is Unrelated to Protection From Erythema and Dependent On Protection From Ultraviolet a in the Face of Constant Ultraviolet B Protection." The Journal of Investigative Dermatology, vol. 121, no. 1, 2003, pp. 184-90.
Poon TS, Barnetson RS, Halliday GM. Prevention of immunosuppression by sunscreens in humans is unrelated to protection from erythema and dependent on protection from ultraviolet a in the face of constant ultraviolet B protection. J Invest Dermatol. 2003;121(1):184-90.
Poon, T. S., Barnetson, R. S., & Halliday, G. M. (2003). Prevention of immunosuppression by sunscreens in humans is unrelated to protection from erythema and dependent on protection from ultraviolet a in the face of constant ultraviolet B protection. The Journal of Investigative Dermatology, 121(1), 184-90.
Poon TS, Barnetson RS, Halliday GM. Prevention of Immunosuppression By Sunscreens in Humans Is Unrelated to Protection From Erythema and Dependent On Protection From Ultraviolet a in the Face of Constant Ultraviolet B Protection. J Invest Dermatol. 2003;121(1):184-90. PubMed PMID: 12839580.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of immunosuppression by sunscreens in humans is unrelated to protection from erythema and dependent on protection from ultraviolet a in the face of constant ultraviolet B protection. AU - Poon,Terence S C, AU - Barnetson,Ross StC, AU - Halliday,Gary M, PY - 2003/7/4/pubmed PY - 2003/8/23/medline PY - 2003/7/4/entrez SP - 184 EP - 90 JF - The Journal of investigative dermatology JO - J Invest Dermatol VL - 121 IS - 1 N2 - Sunscreens have been advocated as an important means of preventing skin cancer. Ultraviolet radiation induced immunosuppression is recognized as an important event in skin cancer development, yet the effectiveness of sunscreens in protecting the human immune system from ultraviolet radiation (i.e. ultraviolet radiation) is still unclear. The only currently accepted method of sunscreen rating is the sun protection factor system based on the prevention of erythema. We determined immune protection factors for six commercially available sunscreens using a nickel contact hypersensitivity model in humans. Both sun protection factor and immune protection factor testing was performed using the same solar simulated ultraviolet radiation source and dose-responses were used to determine endpoints both with and without sunscreens. We found that the immune protection factor did not correlate with the sun protection factor; however, immune protection factor was significantly correlated to the ultraviolet A protective capability of the sunscreens, indicating that sunscreen protection from ultraviolet A is important for the prevention of ultraviolet immunosuppression, when there is constant ultraviolet B protection. We recommend that sunscreens should be rated against their immune protective capability to provide a better indication of their ability to protect against skin cancer. SN - 0022-202X UR - https://www.unboundmedicine.com/medline/citation/12839580/Prevention_of_immunosuppression_by_sunscreens_in_humans_is_unrelated_to_protection_from_erythema_and_dependent_on_protection_from_ultraviolet_a_in_the_face_of_constant_ultraviolet_B_protection_ DB - PRIME DP - Unbound Medicine ER -