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Resistance training with vascular occlusion: metabolic adaptations in human muscle.
Med Sci Sports Exerc. 2003 Jul; 35(7):1203-8.MS

Abstract

Two recent studies have reported increases in strength and whole muscle cross-sectional area after low-intensity resistance training (LIT) with vascular occlusion (OCC) that are greater than LIT alone (e.g., 22, 25). The OCC stress might be expected to induce metabolic alterations that are consistent with compromised oxygen delivery rather than an increase in strength per se, but this has not been studied.

PURPOSE

We examined the effect of LIT and LIT+OCC on resting metabolites in m. biceps brachii and elbow flexor strength.

METHODS

Eight men (19.5 +/- 0.4 yr) performed 8 wk of LIT at approximately 50% of one-repetition maximum (2 sessions per week; 3-6 sets, 8-10 repetitions, final set to failure); one arm trained with OCC and the other without (CON). :Biopsies obtained before and 72 h after the final training bout revealed that resting [glycogen] was higher (P <or= 0.05) in both arms after LIT (CON: 452 +/- 20 vs 325 +/- 28, OCC: 501 +/- 12 vs 332 +/- 28 mmol.kg-1 dry weight) and the increase was larger in the OCC arm (P <or= 0.05). Resting [ATP] was lower (P <or= 0.05) after LIT in both arms (CON: 20.5 +/- 0.5 vs 22.8 +/- 0.7, OCC: 18.2 +/- 0.6 vs 23.1 +/- 0.5 mmol.kg-1 dry weight), and the decrease was larger in the OCC arm (P <or= 0.05). Maximal isotonic and isokinetic elbow flexor strength increased (P <or= 0.05) after training to a similar extent in both arms.

CONCLUSION

We conclude that [glycogen] was increased and [ATP] was decreased in resting human muscle, 72 h after an 8-wk LIT protocol. OCC potentiated the metabolic changes, perhaps by inducing an ischemic stimulus that enhanced muscle glucose transport and adenine nucleotide catabolism after LIT, but did not augment the increases in strength.

Authors+Show Affiliations

Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12840643

Citation

Burgomaster, Kirsten A., et al. "Resistance Training With Vascular Occlusion: Metabolic Adaptations in Human Muscle." Medicine and Science in Sports and Exercise, vol. 35, no. 7, 2003, pp. 1203-8.
Burgomaster KA, Moore DR, Schofield LM, et al. Resistance training with vascular occlusion: metabolic adaptations in human muscle. Med Sci Sports Exerc. 2003;35(7):1203-8.
Burgomaster, K. A., Moore, D. R., Schofield, L. M., Phillips, S. M., Sale, D. G., & Gibala, M. J. (2003). Resistance training with vascular occlusion: metabolic adaptations in human muscle. Medicine and Science in Sports and Exercise, 35(7), 1203-8.
Burgomaster KA, et al. Resistance Training With Vascular Occlusion: Metabolic Adaptations in Human Muscle. Med Sci Sports Exerc. 2003;35(7):1203-8. PubMed PMID: 12840643.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Resistance training with vascular occlusion: metabolic adaptations in human muscle. AU - Burgomaster,Kirsten A, AU - Moore,Dan R, AU - Schofield,Lee M, AU - Phillips,Stuart M, AU - Sale,Digby G, AU - Gibala,Martin J, PY - 2003/7/4/pubmed PY - 2003/10/22/medline PY - 2003/7/4/entrez SP - 1203 EP - 8 JF - Medicine and science in sports and exercise JO - Med Sci Sports Exerc VL - 35 IS - 7 N2 - UNLABELLED: Two recent studies have reported increases in strength and whole muscle cross-sectional area after low-intensity resistance training (LIT) with vascular occlusion (OCC) that are greater than LIT alone (e.g., 22, 25). The OCC stress might be expected to induce metabolic alterations that are consistent with compromised oxygen delivery rather than an increase in strength per se, but this has not been studied. PURPOSE: We examined the effect of LIT and LIT+OCC on resting metabolites in m. biceps brachii and elbow flexor strength. METHODS: Eight men (19.5 +/- 0.4 yr) performed 8 wk of LIT at approximately 50% of one-repetition maximum (2 sessions per week; 3-6 sets, 8-10 repetitions, final set to failure); one arm trained with OCC and the other without (CON). :Biopsies obtained before and 72 h after the final training bout revealed that resting [glycogen] was higher (P <or= 0.05) in both arms after LIT (CON: 452 +/- 20 vs 325 +/- 28, OCC: 501 +/- 12 vs 332 +/- 28 mmol.kg-1 dry weight) and the increase was larger in the OCC arm (P <or= 0.05). Resting [ATP] was lower (P <or= 0.05) after LIT in both arms (CON: 20.5 +/- 0.5 vs 22.8 +/- 0.7, OCC: 18.2 +/- 0.6 vs 23.1 +/- 0.5 mmol.kg-1 dry weight), and the decrease was larger in the OCC arm (P <or= 0.05). Maximal isotonic and isokinetic elbow flexor strength increased (P <or= 0.05) after training to a similar extent in both arms. CONCLUSION: We conclude that [glycogen] was increased and [ATP] was decreased in resting human muscle, 72 h after an 8-wk LIT protocol. OCC potentiated the metabolic changes, perhaps by inducing an ischemic stimulus that enhanced muscle glucose transport and adenine nucleotide catabolism after LIT, but did not augment the increases in strength. SN - 0195-9131 UR - https://www.unboundmedicine.com/medline/citation/12840643/Resistance_training_with_vascular_occlusion:_metabolic_adaptations_in_human_muscle_ L2 - https://doi.org/10.1249/01.MSS.0000074458.71025.71 DB - PRIME DP - Unbound Medicine ER -