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New developments in aetiological mechanisms of inflammatory bowel disease.

Abstract

This review in depth considers the new knowledge and some hypotheses accumulated during the last few years regarding the aetiology of inflammatory bowel disease. The role of genetic susceptibility, in particular the first gene where a mutation is responsible for part of patients with Crohn's disease, is discussed. The consequence for phenotype variability and the environmental influences regarding manifestation of the disease are analysed by experts. Finally, alternative hypotheses including an immune deficiency and defective local bacterial response are demonstrated.

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  • Publisher Full Text
  • Authors+Show Affiliations

    Department of Internal Medicine I, University Regensburg, Germany. juergen.schoelmerich@klinik.uni-r.de

    Source

    MeSH

    Carrier Proteins
    Genetic Predisposition to Disease
    Humans
    Inflammatory Bowel Diseases
    Intracellular Signaling Peptides and Proteins
    Nod2 Signaling Adaptor Protein
    Risk Factors

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    12840666

    Citation

    Schölmerich, Jürgen. "New Developments in Aetiological Mechanisms of Inflammatory Bowel Disease." European Journal of Gastroenterology & Hepatology, vol. 15, no. 6, 2003, pp. 585-6.
    Schölmerich J. New developments in aetiological mechanisms of inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2003;15(6):585-6.
    Schölmerich, J. (2003). New developments in aetiological mechanisms of inflammatory bowel disease. European Journal of Gastroenterology & Hepatology, 15(6), pp. 585-6.
    Schölmerich J. New Developments in Aetiological Mechanisms of Inflammatory Bowel Disease. Eur J Gastroenterol Hepatol. 2003;15(6):585-6. PubMed PMID: 12840666.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - New developments in aetiological mechanisms of inflammatory bowel disease. A1 - Schölmerich,Jürgen, PY - 2003/7/4/pubmed PY - 2003/8/26/medline PY - 2003/7/4/entrez SP - 585 EP - 6 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 15 IS - 6 N2 - This review in depth considers the new knowledge and some hypotheses accumulated during the last few years regarding the aetiology of inflammatory bowel disease. The role of genetic susceptibility, in particular the first gene where a mutation is responsible for part of patients with Crohn's disease, is discussed. The consequence for phenotype variability and the environmental influences regarding manifestation of the disease are analysed by experts. Finally, alternative hypotheses including an immune deficiency and defective local bacterial response are demonstrated. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/12840666/New_developments_in_aetiological_mechanisms_of_inflammatory_bowel_disease_ L2 - http://Insights.ovid.com/pubmed?pmid=12840666 DB - PRIME DP - Unbound Medicine ER -