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New developments in aetiological mechanisms of inflammatory bowel disease.
Eur J Gastroenterol Hepatol 2003; 15(6):585-6EJ

Abstract

This review in depth considers the new knowledge and some hypotheses accumulated during the last few years regarding the aetiology of inflammatory bowel disease. The role of genetic susceptibility, in particular the first gene where a mutation is responsible for part of patients with Crohn's disease, is discussed. The consequence for phenotype variability and the environmental influences regarding manifestation of the disease are analysed by experts. Finally, alternative hypotheses including an immune deficiency and defective local bacterial response are demonstrated.

Authors+Show Affiliations

Department of Internal Medicine I, University Regensburg, Germany. juergen.schoelmerich@klinik.uni-r.de

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12840666

Citation

Schölmerich, Jürgen. "New Developments in Aetiological Mechanisms of Inflammatory Bowel Disease." European Journal of Gastroenterology & Hepatology, vol. 15, no. 6, 2003, pp. 585-6.
Schölmerich J. New developments in aetiological mechanisms of inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2003;15(6):585-6.
Schölmerich, J. (2003). New developments in aetiological mechanisms of inflammatory bowel disease. European Journal of Gastroenterology & Hepatology, 15(6), pp. 585-6.
Schölmerich J. New Developments in Aetiological Mechanisms of Inflammatory Bowel Disease. Eur J Gastroenterol Hepatol. 2003;15(6):585-6. PubMed PMID: 12840666.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New developments in aetiological mechanisms of inflammatory bowel disease. A1 - Schölmerich,Jürgen, PY - 2003/7/4/pubmed PY - 2003/8/26/medline PY - 2003/7/4/entrez SP - 585 EP - 6 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 15 IS - 6 N2 - This review in depth considers the new knowledge and some hypotheses accumulated during the last few years regarding the aetiology of inflammatory bowel disease. The role of genetic susceptibility, in particular the first gene where a mutation is responsible for part of patients with Crohn's disease, is discussed. The consequence for phenotype variability and the environmental influences regarding manifestation of the disease are analysed by experts. Finally, alternative hypotheses including an immune deficiency and defective local bacterial response are demonstrated. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/12840666/New_developments_in_aetiological_mechanisms_of_inflammatory_bowel_disease_ L2 - http://Insights.ovid.com/pubmed?pmid=12840666 DB - PRIME DP - Unbound Medicine ER -