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Telomerase activity in surgical specimens and fine-needle aspiration biopsies from hyperplastic and neoplastic human thyroid tissues.
Am J Surg. 2003 Jul; 186(1):83-8.AJ

Abstract

BACKGROUND

Telomerase activity (TA) indicates malignancy, but activated lymphocytes also express TA. Correlation between TA in thyroid tissues and fine-needle aspiration (FNA) samples and knowledge about TA in adjacent tissue are of importance.

METHODS

The telomeric repeat amplification protocol assay followed by enzyme-linked immunosorbent assay detection was performed on 78 thyroid cases including 53 suspected malignancies, preoperative and perioperative FNA specimens, and adjacent tissue.

RESULTS

Benign lesions in cancer-suspected cases were TA negative. Eight of 13 papillary (62%) and 4 of 5 follicular (80%) tumors were TA positive (TA+). Lower TA was observed in conventional papillary cancer than in follicular, tall cell variant of papillary and anaplastic cancers. Adjacent tissues with lymphocyte infiltration were TA+ in 9 of 17 cases (53%). Nine of 65 adjacent tissues (14%) were TA+. Three of 6 preoperative and 9 of 11 perioperative FNA samples from malignant tumors corresponded to the tissue TA. CONCLUSIONS; High TA may reflect more severe thyroid cancer. Telomerase activity in FNA biopsies does not add reliable diagnostic information, and presence of lymphocytes can give false-positive results.

Authors+Show Affiliations

Division of Surgery, Department of Biomedicine and Surgery, Faculty of Health Sciences, University Hospital, SE-581 85 Linköping, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12842757

Citation

Trulsson, Lena M., et al. "Telomerase Activity in Surgical Specimens and Fine-needle Aspiration Biopsies From Hyperplastic and Neoplastic Human Thyroid Tissues." American Journal of Surgery, vol. 186, no. 1, 2003, pp. 83-8.
Trulsson LM, Velin AK, Herder A, et al. Telomerase activity in surgical specimens and fine-needle aspiration biopsies from hyperplastic and neoplastic human thyroid tissues. Am J Surg. 2003;186(1):83-8.
Trulsson, L. M., Velin, A. K., Herder, A., Söderkvist, P., Rüter, A., & Smeds, S. (2003). Telomerase activity in surgical specimens and fine-needle aspiration biopsies from hyperplastic and neoplastic human thyroid tissues. American Journal of Surgery, 186(1), 83-8.
Trulsson LM, et al. Telomerase Activity in Surgical Specimens and Fine-needle Aspiration Biopsies From Hyperplastic and Neoplastic Human Thyroid Tissues. Am J Surg. 2003;186(1):83-8. PubMed PMID: 12842757.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Telomerase activity in surgical specimens and fine-needle aspiration biopsies from hyperplastic and neoplastic human thyroid tissues. AU - Trulsson,Lena M, AU - Velin,Asa K, AU - Herder,Anders, AU - Söderkvist,Peter, AU - Rüter,Anders, AU - Smeds,Staffan, PY - 2003/7/5/pubmed PY - 2003/8/6/medline PY - 2003/7/5/entrez SP - 83 EP - 8 JF - American journal of surgery JO - Am J Surg VL - 186 IS - 1 N2 - BACKGROUND: Telomerase activity (TA) indicates malignancy, but activated lymphocytes also express TA. Correlation between TA in thyroid tissues and fine-needle aspiration (FNA) samples and knowledge about TA in adjacent tissue are of importance. METHODS: The telomeric repeat amplification protocol assay followed by enzyme-linked immunosorbent assay detection was performed on 78 thyroid cases including 53 suspected malignancies, preoperative and perioperative FNA specimens, and adjacent tissue. RESULTS: Benign lesions in cancer-suspected cases were TA negative. Eight of 13 papillary (62%) and 4 of 5 follicular (80%) tumors were TA positive (TA+). Lower TA was observed in conventional papillary cancer than in follicular, tall cell variant of papillary and anaplastic cancers. Adjacent tissues with lymphocyte infiltration were TA+ in 9 of 17 cases (53%). Nine of 65 adjacent tissues (14%) were TA+. Three of 6 preoperative and 9 of 11 perioperative FNA samples from malignant tumors corresponded to the tissue TA. CONCLUSIONS; High TA may reflect more severe thyroid cancer. Telomerase activity in FNA biopsies does not add reliable diagnostic information, and presence of lymphocytes can give false-positive results. SN - 0002-9610 UR - https://www.unboundmedicine.com/medline/citation/12842757/Telomerase_activity_in_surgical_specimens_and_fine_needle_aspiration_biopsies_from_hyperplastic_and_neoplastic_human_thyroid_tissues_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002961003001193 DB - PRIME DP - Unbound Medicine ER -