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[Amyloid neuropathies. Histopathological study of peripheral nerve biopsy in 18 cases].
Ann Pathol. 2003 Apr; 23(2):114-20.AP

Abstract

OBJECTIVES

A retrospective study of nerve and muscle biopsies since 1983, with probable amyloidosis, has been performed.

MATERIALS AND METHODS

Eighteen nerve and muscle biopsies, out of 29, were selected.

RESULTS

Endoneurial amyloid deposits were visible on routine sections in 11 cases, revealed by ultrastructural study in 4 cases and by Congo red and/or thioflavine stains in 3 others. Amyloid deposits were marked by anti-transthyretin (TTR) serum in 13 patients, within endoneurium in 11 cases, and only around muscle fibers in 2 others. A mutation in the TTR gene, usually Val30Met, was evidenced in 8 cases and could not be assayed in the 5 others. An immunoglobulin light chain was revealed in amyloid deposits by direct immunofluorescence in the 5 other patients, of whom 4 had multiple myeloma and the fifth a lambda light chain Bence-Jones proteinuria.

CONCLUSION

Nerve biopsy revealed amyloidosis in 10 patients: 5 of them had a mutation in TTR gene, without any family history.

Authors+Show Affiliations

Laboratoire de Neuropathologie, Université Victor Segalen, Bordeaux 2.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

12843966

Citation

Bouillot, Sandrine, et al. "[Amyloid Neuropathies. Histopathological Study of Peripheral Nerve Biopsy in 18 Cases]." Annales De Pathologie, vol. 23, no. 2, 2003, pp. 114-20.
Bouillot S, Vital A, Favereaux A, et al. [Amyloid neuropathies. Histopathological study of peripheral nerve biopsy in 18 cases]. Ann Pathol. 2003;23(2):114-20.
Bouillot, S., Vital, A., Favereaux, A., Ferrer, X., Lagueny, A., & Vital, C. (2003). [Amyloid neuropathies. Histopathological study of peripheral nerve biopsy in 18 cases]. Annales De Pathologie, 23(2), 114-20.
Bouillot S, et al. [Amyloid Neuropathies. Histopathological Study of Peripheral Nerve Biopsy in 18 Cases]. Ann Pathol. 2003;23(2):114-20. PubMed PMID: 12843966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Amyloid neuropathies. Histopathological study of peripheral nerve biopsy in 18 cases]. AU - Bouillot,Sandrine, AU - Vital,Anne, AU - Favereaux,Alexandre, AU - Ferrer,Xavier, AU - Lagueny,Alain, AU - Vital,Claude, PY - 2003/7/5/pubmed PY - 2003/8/9/medline PY - 2003/7/5/entrez SP - 114 EP - 20 JF - Annales de pathologie JO - Ann Pathol VL - 23 IS - 2 N2 - OBJECTIVES: A retrospective study of nerve and muscle biopsies since 1983, with probable amyloidosis, has been performed. MATERIALS AND METHODS: Eighteen nerve and muscle biopsies, out of 29, were selected. RESULTS: Endoneurial amyloid deposits were visible on routine sections in 11 cases, revealed by ultrastructural study in 4 cases and by Congo red and/or thioflavine stains in 3 others. Amyloid deposits were marked by anti-transthyretin (TTR) serum in 13 patients, within endoneurium in 11 cases, and only around muscle fibers in 2 others. A mutation in the TTR gene, usually Val30Met, was evidenced in 8 cases and could not be assayed in the 5 others. An immunoglobulin light chain was revealed in amyloid deposits by direct immunofluorescence in the 5 other patients, of whom 4 had multiple myeloma and the fifth a lambda light chain Bence-Jones proteinuria. CONCLUSION: Nerve biopsy revealed amyloidosis in 10 patients: 5 of them had a mutation in TTR gene, without any family history. SN - 0242-6498 UR - https://www.unboundmedicine.com/medline/citation/12843966/[Amyloid_neuropathies__Histopathological_study_of_peripheral_nerve_biopsy_in_18_cases]_ L2 - https://medlineplus.gov/amyloidosis.html DB - PRIME DP - Unbound Medicine ER -