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Prevalence of autoantibodies in patients with endemic pemphigus foliaceus (fogo selvagem).
Arch Dermatol Res. 2003 Aug; 295(4):133-7.AD

Abstract

OBJECTIVE

The aim of the present study was to investigate a broad spectrum of autoantibodies in patients with endemic pemphigus foliaceus (EPF)-fogo selvagem-and to determine the possible association between EPF and other autoimmune diseases.

MATERIALS AND METHODS

Indirect immunofluorescence was used to test 120 patients with EPF and 200 healthy controls for the presence of the following autoantibodies: anti-desmoglein-1 (APF), anti-neutrophil cytoplasmic (ANCA), anti-smooth muscle (SMA), anti-mitochondrial (AMA), anti-nuclear (ANA), anti-liver kidney microsomal (LKM), anti-gastric parietal cells (GPCA) and anti-thyroid microsome (TMA).

RESULTS

APF antibodies were detected in 62.5% of the patients (75/120), ANA and SMA in 0.8% (1/120), and TMA in 1.6% (2/120). None of the patients was positive for ANCA, AMA, LKM or GPCA. In the control group, a positivity of 2% was observed for SMA (4/200), 1.5% for TMA (3/200), and 0.5% (1/200) for ANA and GPCA. None of the controls was positive for APF, LKM, AMA or ANCA.

CONCLUSIONS

The prevalence of the autoantibodies ANA, SMA, AMA, GPCA, LKM and ANCA in patients with EPF was similar to that observed in the control group. No association with clinical or laboratory manifestations of other concomitant autoimmune diseases was observed in EPF patients. These results confirm the concept that EPF is an organ-specific autoimmune disease.

Authors+Show Affiliations

Laboratory of Immunopathology, Department of Medical Pathology, University Hospital, Federal University of Paraná, Center for Health Sciences, Rua General Carneiro no. 181, CEP 80060-900 Curitiba-PR, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12844225

Citation

Nisihara, Renato Mitsunori, et al. "Prevalence of Autoantibodies in Patients With Endemic Pemphigus Foliaceus (fogo Selvagem)." Archives of Dermatological Research, vol. 295, no. 4, 2003, pp. 133-7.
Nisihara RM, de Bem RS, Hausberger R, et al. Prevalence of autoantibodies in patients with endemic pemphigus foliaceus (fogo selvagem). Arch Dermatol Res. 2003;295(4):133-7.
Nisihara, R. M., de Bem, R. S., Hausberger, R., Roxo, V. S., Pavoni, D. P., Petzl-Erler, M. L., & de Messias-Reason, I. J. (2003). Prevalence of autoantibodies in patients with endemic pemphigus foliaceus (fogo selvagem). Archives of Dermatological Research, 295(4), 133-7.
Nisihara RM, et al. Prevalence of Autoantibodies in Patients With Endemic Pemphigus Foliaceus (fogo Selvagem). Arch Dermatol Res. 2003;295(4):133-7. PubMed PMID: 12844225.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of autoantibodies in patients with endemic pemphigus foliaceus (fogo selvagem). AU - Nisihara,Renato Mitsunori, AU - de Bem,Ricardo Schmitt, AU - Hausberger,Romeu, AU - Roxo,Valéria Sperandio, AU - Pavoni,Daniela Parada, AU - Petzl-Erler,Maria Luiza, AU - de Messias-Reason,Iara José, Y1 - 2003/07/03/ PY - 2002/11/27/received PY - 2003/03/04/revised PY - 2003/05/23/accepted PY - 2003/7/5/pubmed PY - 2004/5/13/medline PY - 2003/7/5/entrez SP - 133 EP - 7 JF - Archives of dermatological research JO - Arch Dermatol Res VL - 295 IS - 4 N2 - OBJECTIVE: The aim of the present study was to investigate a broad spectrum of autoantibodies in patients with endemic pemphigus foliaceus (EPF)-fogo selvagem-and to determine the possible association between EPF and other autoimmune diseases. MATERIALS AND METHODS: Indirect immunofluorescence was used to test 120 patients with EPF and 200 healthy controls for the presence of the following autoantibodies: anti-desmoglein-1 (APF), anti-neutrophil cytoplasmic (ANCA), anti-smooth muscle (SMA), anti-mitochondrial (AMA), anti-nuclear (ANA), anti-liver kidney microsomal (LKM), anti-gastric parietal cells (GPCA) and anti-thyroid microsome (TMA). RESULTS: APF antibodies were detected in 62.5% of the patients (75/120), ANA and SMA in 0.8% (1/120), and TMA in 1.6% (2/120). None of the patients was positive for ANCA, AMA, LKM or GPCA. In the control group, a positivity of 2% was observed for SMA (4/200), 1.5% for TMA (3/200), and 0.5% (1/200) for ANA and GPCA. None of the controls was positive for APF, LKM, AMA or ANCA. CONCLUSIONS: The prevalence of the autoantibodies ANA, SMA, AMA, GPCA, LKM and ANCA in patients with EPF was similar to that observed in the control group. No association with clinical or laboratory manifestations of other concomitant autoimmune diseases was observed in EPF patients. These results confirm the concept that EPF is an organ-specific autoimmune disease. SN - 0340-3696 UR - https://www.unboundmedicine.com/medline/citation/12844225/Prevalence_of_autoantibodies_in_patients_with_endemic_pemphigus_foliaceus__fogo_selvagem__ L2 - https://link.springer.com/article/10.1007/s00403-003-0412-9 DB - PRIME DP - Unbound Medicine ER -