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Food allergy as a risk factor for life-threatening asthma in childhood: a case-controlled study.
J Allergy Clin Immunol 2003; 112(1):168-74JA

Abstract

BACKGROUND

No objective clinical risk factors exist for pediatric life-threatening asthma.

OBJECTIVES

In this study, we address whether persistent food allergy and degree of atopy are risk factors for life-threatening asthma.

METHODS

By use of a case-controlled design, children (1-16 years) ventilated for an exacerbation of asthma were enrolled. Each case was matched by sex, age, and ethnicity, with 2 controls who had attended with a non-life-threatening exacerbation. All subjects were assessed by means of a questionnaire, spirometry, and skin prick or RAST testing. The data were analyzed by conditional logistic regression.

RESULTS

Nineteen cases and 38 controls were enrolled. Compared with controls, cases were found to have the following risk factors: food allergy (odds ratio, 8.58; 95% CI, 1.85-39.71), multiple allergic diagnoses (4.42; 1.17-16.71), early onset of asthma (6.48; 1.36-30.85), and frequent admissions (14.2; 1.77-113.59). After regression analysis, only frequent admission with asthma (9.85; 1.04-93.27) and food allergy (5.89; 1.06-32.61) were independently associated with life-threatening asthma. Half the cases had food allergy compared with only 10% of controls.

CONCLUSION

This study demonstrates that poorly controlled asthma and food allergy are significant risk factors for life-threatening asthma. More intensive management of this high-risk group of children might help to reduce future morbidity and mortality.

Authors+Show Affiliations

Department of Paediatric Allergy and Clinical Immunology, St Mary's Hospital, London.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12847494

Citation

Roberts, Graham, et al. "Food Allergy as a Risk Factor for Life-threatening Asthma in Childhood: a Case-controlled Study." The Journal of Allergy and Clinical Immunology, vol. 112, no. 1, 2003, pp. 168-74.
Roberts G, Patel N, Levi-Schaffer F, et al. Food allergy as a risk factor for life-threatening asthma in childhood: a case-controlled study. J Allergy Clin Immunol. 2003;112(1):168-74.
Roberts, G., Patel, N., Levi-Schaffer, F., Habibi, P., & Lack, G. (2003). Food allergy as a risk factor for life-threatening asthma in childhood: a case-controlled study. The Journal of Allergy and Clinical Immunology, 112(1), pp. 168-74.
Roberts G, et al. Food Allergy as a Risk Factor for Life-threatening Asthma in Childhood: a Case-controlled Study. J Allergy Clin Immunol. 2003;112(1):168-74. PubMed PMID: 12847494.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Food allergy as a risk factor for life-threatening asthma in childhood: a case-controlled study. AU - Roberts,Graham, AU - Patel,Neeta, AU - Levi-Schaffer,Francesca, AU - Habibi,Parviz, AU - Lack,Gideon, PY - 2003/7/9/pubmed PY - 2003/8/15/medline PY - 2003/7/9/entrez SP - 168 EP - 74 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 112 IS - 1 N2 - BACKGROUND: No objective clinical risk factors exist for pediatric life-threatening asthma. OBJECTIVES: In this study, we address whether persistent food allergy and degree of atopy are risk factors for life-threatening asthma. METHODS: By use of a case-controlled design, children (1-16 years) ventilated for an exacerbation of asthma were enrolled. Each case was matched by sex, age, and ethnicity, with 2 controls who had attended with a non-life-threatening exacerbation. All subjects were assessed by means of a questionnaire, spirometry, and skin prick or RAST testing. The data were analyzed by conditional logistic regression. RESULTS: Nineteen cases and 38 controls were enrolled. Compared with controls, cases were found to have the following risk factors: food allergy (odds ratio, 8.58; 95% CI, 1.85-39.71), multiple allergic diagnoses (4.42; 1.17-16.71), early onset of asthma (6.48; 1.36-30.85), and frequent admissions (14.2; 1.77-113.59). After regression analysis, only frequent admission with asthma (9.85; 1.04-93.27) and food allergy (5.89; 1.06-32.61) were independently associated with life-threatening asthma. Half the cases had food allergy compared with only 10% of controls. CONCLUSION: This study demonstrates that poorly controlled asthma and food allergy are significant risk factors for life-threatening asthma. More intensive management of this high-risk group of children might help to reduce future morbidity and mortality. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/12847494/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091674903013848 DB - PRIME DP - Unbound Medicine ER -