Tags

Type your tag names separated by a space and hit enter

Fuel metabolism in adult individuals with a wide range of body mass index: effect of a family history of type 2 diabetes.
Diabetes Nutr Metab 2003; 16(1):41-7DN

Abstract

OBJECTIVE

To evaluate whether a family history of Type 2 diabetes mellitus (T2DM) is associated with changes of fuel metabolism in normal glucose tolerant men and women with a wide range of BMI.

DESIGN

Cross-sectional study of resting energy expenditure (REE) and substrate oxidation in adult individuals.

SUBJECTS

Ninety-seven normal weight, overweight, and obese men and women, aged 18-45 years: 44 (38 pre-menopausal women and 6 men) with a first-degree family history of T2DM (FH+) and 53 (45 pre-menopausal women and 8 men) with no family history of T2DM (FH-).

MEASUREMENTS

REE, fat-free mass (FFM)-adjusted REE (REE/Kg FFM), respiratory quotient (RQ), substrate oxidation (carbohydrates, lipids, and proteins), energy intake, anthropometric parameters, body composition (evaluated by BIA), blood pressure, insulin sensitivity (as calculated by Homeostatic Model Assessment) and metabolic variables (fasting levels of insulin, glucose, and lipids).

RESULTS

REE, REE/Kg FFM, and lipid oxidation were lower, whereas carbohydrate oxidation and RQ were higher in FH+ than in FH- individuals.

CONCLUSIONS

This study suggests that a family history of T2DM decreases REE, REE/Kg FFM and lipid oxidation, thus possibly contributing to the development of obesity and to the adverse metabolic profile of subjects with a genetic background for T2DM.

Authors+Show Affiliations

Internal Medicine, Endocrinology and Metabolic Diseases, Department of Emergency and Transplant, University of Bari, Bari, Italy. gdepergola@libero.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12848304

Citation

De Pergola, G, et al. "Fuel Metabolism in Adult Individuals With a Wide Range of Body Mass Index: Effect of a Family History of Type 2 Diabetes." Diabetes, Nutrition & Metabolism, vol. 16, no. 1, 2003, pp. 41-7.
De Pergola G, Pannacciulli N, Minenna A, et al. Fuel metabolism in adult individuals with a wide range of body mass index: effect of a family history of type 2 diabetes. Diabetes Nutr Metab. 2003;16(1):41-7.
De Pergola, G., Pannacciulli, N., Minenna, A., Martina, R. A., Cannito, F., & Giorgino, R. (2003). Fuel metabolism in adult individuals with a wide range of body mass index: effect of a family history of type 2 diabetes. Diabetes, Nutrition & Metabolism, 16(1), pp. 41-7.
De Pergola G, et al. Fuel Metabolism in Adult Individuals With a Wide Range of Body Mass Index: Effect of a Family History of Type 2 Diabetes. Diabetes Nutr Metab. 2003;16(1):41-7. PubMed PMID: 12848304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fuel metabolism in adult individuals with a wide range of body mass index: effect of a family history of type 2 diabetes. AU - De Pergola,G, AU - Pannacciulli,N, AU - Minenna,A, AU - Martina,R A, AU - Cannito,F, AU - Giorgino,R, PY - 2003/7/10/pubmed PY - 2003/12/19/medline PY - 2003/7/10/entrez SP - 41 EP - 7 JF - Diabetes, nutrition & metabolism JO - Diabetes Nutr. Metab. VL - 16 IS - 1 N2 - OBJECTIVE: To evaluate whether a family history of Type 2 diabetes mellitus (T2DM) is associated with changes of fuel metabolism in normal glucose tolerant men and women with a wide range of BMI. DESIGN: Cross-sectional study of resting energy expenditure (REE) and substrate oxidation in adult individuals. SUBJECTS: Ninety-seven normal weight, overweight, and obese men and women, aged 18-45 years: 44 (38 pre-menopausal women and 6 men) with a first-degree family history of T2DM (FH+) and 53 (45 pre-menopausal women and 8 men) with no family history of T2DM (FH-). MEASUREMENTS: REE, fat-free mass (FFM)-adjusted REE (REE/Kg FFM), respiratory quotient (RQ), substrate oxidation (carbohydrates, lipids, and proteins), energy intake, anthropometric parameters, body composition (evaluated by BIA), blood pressure, insulin sensitivity (as calculated by Homeostatic Model Assessment) and metabolic variables (fasting levels of insulin, glucose, and lipids). RESULTS: REE, REE/Kg FFM, and lipid oxidation were lower, whereas carbohydrate oxidation and RQ were higher in FH+ than in FH- individuals. CONCLUSIONS: This study suggests that a family history of T2DM decreases REE, REE/Kg FFM and lipid oxidation, thus possibly contributing to the development of obesity and to the adverse metabolic profile of subjects with a genetic background for T2DM. SN - 0394-3402 UR - https://www.unboundmedicine.com/medline/citation/12848304/Fuel_metabolism_in_adult_individuals_with_a_wide_range_of_body_mass_index:_effect_of_a_family_history_of_type_2_diabetes_ L2 - https://ClinicalTrials.gov/search/term=12848304 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -