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Photometric and clinical assessment of localized UVB phototherapy systems for the high-dosage treatment of stable plaque psoriasis.

Abstract

BACKGROUND

Ultraviolet-B (UVB) light sources are widely used for the safe and effective treatment of inflammatory skin conditions. The recent commercial introduction of fiber-coupled UVB phototherapy systems facilitates the selective exposure and treatment of localized psoriasis plaques while permitting the safe use of high-dosage treatments.

OBJECTIVE

In this study, the performance characteristics and clinical outcome of psoriasis treatments were assessed when using two technologically distinct sources of high-intensity, fiber-optically delivered therapeutic UVB.

METHODS

A pulsed, monochromatic 308 nm excimer laser and a continuous-wave, incoherent UVB light source were compared using photosensitive recording papers, images captured with a CCD camera, and on the healthy and lesional skin of ten psoriasis patients.

RESULTS

Beam profile analyses and minimal erythema dose (MED) test spots revealed distinct energy distribution patterns from the two devices. The Guassian-type laser beam energy distribution complicated MED determinations, whereas skin exposed to light from the incoherent UVB system developed a more uniform erythema. Both systems cleared the treated psoriasis plaques equivalently, requiring no more than two to five weeks of high-dose treatments.

CONCLUSION

When used at equally erythemogenic high doses, both systems produced rapid plaque clearance with minimal side effects. Unlike conventional phototherapy, localized UVB minimizes exposure to the healthy skin, making it suitable for patients with mild to moderate psoriasis, individuals with recalcitrant plaques and for the successful treatment of lesions occurring on most body sites.

Authors+Show Affiliations

,

Center for Dermatology and Laser Surgery, Sacramento, CA 95819, USA. tanghetti@mgci.com

Source

MeSH

Adult
Humans
Laser Therapy
Prospective Studies
Psoriasis
Ultraviolet Therapy

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12850797

Citation

Tanghetti, Emil, and Paul R. Gillis. "Photometric and Clinical Assessment of Localized UVB Phototherapy Systems for the High-dosage Treatment of Stable Plaque Psoriasis." Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology, vol. 5, no. 2, 2003, pp. 101-6.
Tanghetti E, Gillis PR. Photometric and clinical assessment of localized UVB phototherapy systems for the high-dosage treatment of stable plaque psoriasis. J Cosmet Laser Ther. 2003;5(2):101-6.
Tanghetti, E., & Gillis, P. R. (2003). Photometric and clinical assessment of localized UVB phototherapy systems for the high-dosage treatment of stable plaque psoriasis. Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology, 5(2), pp. 101-6.
Tanghetti E, Gillis PR. Photometric and Clinical Assessment of Localized UVB Phototherapy Systems for the High-dosage Treatment of Stable Plaque Psoriasis. J Cosmet Laser Ther. 2003;5(2):101-6. PubMed PMID: 12850797.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Photometric and clinical assessment of localized UVB phototherapy systems for the high-dosage treatment of stable plaque psoriasis. AU - Tanghetti,Emil, AU - Gillis,Paul R, PY - 2003/7/10/pubmed PY - 2003/10/22/medline PY - 2003/7/10/entrez SP - 101 EP - 6 JF - Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology JO - J Cosmet Laser Ther VL - 5 IS - 2 N2 - BACKGROUND: Ultraviolet-B (UVB) light sources are widely used for the safe and effective treatment of inflammatory skin conditions. The recent commercial introduction of fiber-coupled UVB phototherapy systems facilitates the selective exposure and treatment of localized psoriasis plaques while permitting the safe use of high-dosage treatments. OBJECTIVE: In this study, the performance characteristics and clinical outcome of psoriasis treatments were assessed when using two technologically distinct sources of high-intensity, fiber-optically delivered therapeutic UVB. METHODS: A pulsed, monochromatic 308 nm excimer laser and a continuous-wave, incoherent UVB light source were compared using photosensitive recording papers, images captured with a CCD camera, and on the healthy and lesional skin of ten psoriasis patients. RESULTS: Beam profile analyses and minimal erythema dose (MED) test spots revealed distinct energy distribution patterns from the two devices. The Guassian-type laser beam energy distribution complicated MED determinations, whereas skin exposed to light from the incoherent UVB system developed a more uniform erythema. Both systems cleared the treated psoriasis plaques equivalently, requiring no more than two to five weeks of high-dose treatments. CONCLUSION: When used at equally erythemogenic high doses, both systems produced rapid plaque clearance with minimal side effects. Unlike conventional phototherapy, localized UVB minimizes exposure to the healthy skin, making it suitable for patients with mild to moderate psoriasis, individuals with recalcitrant plaques and for the successful treatment of lesions occurring on most body sites. SN - 1476-4172 UR - https://www.unboundmedicine.com/medline/citation/12850797/Photometric_and_clinical_assessment_of_localized_UVB_phototherapy_systems_for_the_high_dosage_treatment_of_stable_plaque_psoriasis_ L2 - http://www.diseaseinfosearch.org/result/6059 DB - PRIME DP - Unbound Medicine ER -