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Comparison of Pueraria lobata with hormone replacement therapy in treating the adverse health consequences of menopause.
Menopause 2003 Jul-Aug; 10(4):352-61M

Abstract

OBJECTIVE

Pueraria lobata (PL) is used as a traditional Chinese herbal remedy for menopausal symptoms, as well as an ingredient in preparations for conditions affecting menopausal women, such as osteoporosis, coronary heart disease, and some hormone-dependent cancers. The scientific basis for its action may be its action as a phytoestrogen.

DESIGN

To examine the effects of PL in comparison with hormone replacement therapy (HRT) on lipid profile, sex hormone levels, bone turnover markers, and indices of cognitive function. For the study, 127 community-living, postmenopausal women aged 50 to 65 years were randomized to receive HRT (n = 43), PL (equivalent to 100 mg isoflavone; n = 45), or no treatment (n = 39) for 3 months. The following measurements were carried out at baseline and after 3 months for all participants: menopausal symptoms questionnaire; neuropsychological tests covering memory, attention, motor speed, and word-finding ability; quality of life (SF36); lipid profile; urinary deoxypyridinoline; dietary phytoestrogen intake and urinary phytoestrogen; estradiol; follicle-stimulating hormone; and luteinizing hormone.

RESULTS

Only participants in the HRT group showed a mean reduction in cholesterol and low-density lipoprotein cholesterol that was significantly different from that of the control group. No significant changes in lipid profile or follicle-stimulating hormone and luteinizing hormone were observed in the PL group compared with the controls. However, both the HRT and PL groups showed an improvement in Mini-Mental State Examination score and attention span compared with the case of participants receiving no treatment. HRT and PL had different effects on cognitive function; HRT improved delayed recall, whereas flexible thinking seemed improved in the PL group.

CONCLUSIONS

This study was unable to demonstrate a scientific basis for the use of PL for improving the health of postmenopausal women in general. However, the effect of PL on cognitive function deserves further study.

Authors+Show Affiliations

Department of Community and Family Medicine, The Chinese University of Hong Kong, Hong Kong. jeanwoowong@cuhk.edu.hkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12851519

Citation

Woo, Jean, et al. "Comparison of Pueraria Lobata With Hormone Replacement Therapy in Treating the Adverse Health Consequences of Menopause." Menopause (New York, N.Y.), vol. 10, no. 4, 2003, pp. 352-61.
Woo J, Lau E, Ho SC, et al. Comparison of Pueraria lobata with hormone replacement therapy in treating the adverse health consequences of menopause. Menopause. 2003;10(4):352-61.
Woo, J., Lau, E., Ho, S. C., Cheng, F., Chan, C., Chan, A. S., ... Sham, A. (2003). Comparison of Pueraria lobata with hormone replacement therapy in treating the adverse health consequences of menopause. Menopause (New York, N.Y.), 10(4), pp. 352-61.
Woo J, et al. Comparison of Pueraria Lobata With Hormone Replacement Therapy in Treating the Adverse Health Consequences of Menopause. Menopause. 2003;10(4):352-61. PubMed PMID: 12851519.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of Pueraria lobata with hormone replacement therapy in treating the adverse health consequences of menopause. AU - Woo,Jean, AU - Lau,Edith, AU - Ho,Suzanne C, AU - Cheng,Francis, AU - Chan,Cynthia, AU - Chan,Agnes S Y, AU - Haines,Christopher J, AU - Chan,Thomas Y K, AU - Li,Martin, AU - Sham,Aprille, PY - 2003/7/10/pubmed PY - 2003/10/8/medline PY - 2003/7/10/entrez SP - 352 EP - 61 JF - Menopause (New York, N.Y.) JO - Menopause VL - 10 IS - 4 N2 - OBJECTIVE: Pueraria lobata (PL) is used as a traditional Chinese herbal remedy for menopausal symptoms, as well as an ingredient in preparations for conditions affecting menopausal women, such as osteoporosis, coronary heart disease, and some hormone-dependent cancers. The scientific basis for its action may be its action as a phytoestrogen. DESIGN: To examine the effects of PL in comparison with hormone replacement therapy (HRT) on lipid profile, sex hormone levels, bone turnover markers, and indices of cognitive function. For the study, 127 community-living, postmenopausal women aged 50 to 65 years were randomized to receive HRT (n = 43), PL (equivalent to 100 mg isoflavone; n = 45), or no treatment (n = 39) for 3 months. The following measurements were carried out at baseline and after 3 months for all participants: menopausal symptoms questionnaire; neuropsychological tests covering memory, attention, motor speed, and word-finding ability; quality of life (SF36); lipid profile; urinary deoxypyridinoline; dietary phytoestrogen intake and urinary phytoestrogen; estradiol; follicle-stimulating hormone; and luteinizing hormone. RESULTS: Only participants in the HRT group showed a mean reduction in cholesterol and low-density lipoprotein cholesterol that was significantly different from that of the control group. No significant changes in lipid profile or follicle-stimulating hormone and luteinizing hormone were observed in the PL group compared with the controls. However, both the HRT and PL groups showed an improvement in Mini-Mental State Examination score and attention span compared with the case of participants receiving no treatment. HRT and PL had different effects on cognitive function; HRT improved delayed recall, whereas flexible thinking seemed improved in the PL group. CONCLUSIONS: This study was unable to demonstrate a scientific basis for the use of PL for improving the health of postmenopausal women in general. However, the effect of PL on cognitive function deserves further study. SN - 1072-3714 UR - https://www.unboundmedicine.com/medline/citation/12851519/Comparison_of_Pueraria_lobata_with_hormone_replacement_therapy_in_treating_the_adverse_health_consequences_of_menopause_ L2 - http://Insights.ovid.com/pubmed?pmid=12851519 DB - PRIME DP - Unbound Medicine ER -