Tags

Type your tag names separated by a space and hit enter

Effect of ascorbic acid consumption on urinary stone risk factors.
J Urol. 2003 Aug; 170(2 Pt 1):397-401.JU

Abstract

PURPOSE

Ascorbic acid (AA) has been implicated as a risk factor for calcium oxalate stones due to its conversion to oxalate and potential acidifying properties. We evaluated the effect of AA consumption on urinary saturation of calcium oxalate (CaOx) and urinary pH.

MATERIALS AND METHODS

A total of 12 normal subjects (NS) and 12 CaOx stone formers (SF) underwent 2, 6-day phases of study while maintained on a controlled metabolic diet. In each phase subjects ingested 1 gm AA or an identical appearing placebo twice daily. On the last 2 days of each phase 2, 24-hour urine collections were analyzed for pH and stone risk factors, and blood specimens were submitted for serum chemistry studies.

RESULTS

No difference in urinary pH was found between placebo and AA phases in NS (6.02 versus 6.02) and SF (6.0 versus 6.0). However, urinary oxalate was statistically significantly higher in the AA versus placebo phase for NS (34.7 versus 28.5 mg, p = 0.008) and SF (41.0 versus 30.5 mg, p <0.001). Likewise, the CaOx relative saturation ratio was significantly higher in the AA versus placebo phase for both groups.

CONCLUSIONS

Ingestion of 2 gm AA daily results in no change in urinary pH but a moderate though statistically significant increase in urinary oxalate in NS (20%) and SF (33%). Stone formers respond no differently to AA than normal subjects. We recommend limiting AA use to less than 2 gm daily in CaOx stone formers.

Authors+Show Affiliations

Department of Urology, The University of Texas Southwestern Medical Center, Dallas, 75390-9110, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

12853784

Citation

Traxer, Olivier, et al. "Effect of Ascorbic Acid Consumption On Urinary Stone Risk Factors." The Journal of Urology, vol. 170, no. 2 Pt 1, 2003, pp. 397-401.
Traxer O, Huet B, Poindexter J, et al. Effect of ascorbic acid consumption on urinary stone risk factors. J Urol. 2003;170(2 Pt 1):397-401.
Traxer, O., Huet, B., Poindexter, J., Pak, C. Y., & Pearle, M. S. (2003). Effect of ascorbic acid consumption on urinary stone risk factors. The Journal of Urology, 170(2 Pt 1), 397-401.
Traxer O, et al. Effect of Ascorbic Acid Consumption On Urinary Stone Risk Factors. J Urol. 2003;170(2 Pt 1):397-401. PubMed PMID: 12853784.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of ascorbic acid consumption on urinary stone risk factors. AU - Traxer,Olivier, AU - Huet,Beverley, AU - Poindexter,John, AU - Pak,Charles Y C, AU - Pearle,Margaret S, PY - 2003/7/11/pubmed PY - 2003/7/31/medline PY - 2003/7/11/entrez KW - Non-programmatic SP - 397 EP - 401 JF - The Journal of urology JO - J. Urol. VL - 170 IS - 2 Pt 1 N2 - PURPOSE: Ascorbic acid (AA) has been implicated as a risk factor for calcium oxalate stones due to its conversion to oxalate and potential acidifying properties. We evaluated the effect of AA consumption on urinary saturation of calcium oxalate (CaOx) and urinary pH. MATERIALS AND METHODS: A total of 12 normal subjects (NS) and 12 CaOx stone formers (SF) underwent 2, 6-day phases of study while maintained on a controlled metabolic diet. In each phase subjects ingested 1 gm AA or an identical appearing placebo twice daily. On the last 2 days of each phase 2, 24-hour urine collections were analyzed for pH and stone risk factors, and blood specimens were submitted for serum chemistry studies. RESULTS: No difference in urinary pH was found between placebo and AA phases in NS (6.02 versus 6.02) and SF (6.0 versus 6.0). However, urinary oxalate was statistically significantly higher in the AA versus placebo phase for NS (34.7 versus 28.5 mg, p = 0.008) and SF (41.0 versus 30.5 mg, p <0.001). Likewise, the CaOx relative saturation ratio was significantly higher in the AA versus placebo phase for both groups. CONCLUSIONS: Ingestion of 2 gm AA daily results in no change in urinary pH but a moderate though statistically significant increase in urinary oxalate in NS (20%) and SF (33%). Stone formers respond no differently to AA than normal subjects. We recommend limiting AA use to less than 2 gm daily in CaOx stone formers. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/12853784/Effect_of_ascorbic_acid_consumption_on_urinary_stone_risk_factors_ L2 - https://www.jurology.com/doi/full/10.1097/01.ju.0000076001.21606.53?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -