Tags

Type your tag names separated by a space and hit enter

Topical mometasone furoate for vulvar lichen sclerosus.
J Reprod Med. 2003 Jun; 48(6):444-8.JR

Abstract

OBJECTIVE

To assess the efficacy and safety of treating vulvar lichen sclerosus with mometasone furoate, a synthetic analogue of beclomethasone.

STUDY DESIGN

Thirty-one consecutive patients with biopsy-proven vulvar lichen sclerosus (LS) seen at the Florence Vulvar Clinic were entered into the study. Each subject's symptoms and the gross appearance of the lesions were recorded using a severity score according to the authors' previous studies. The patients were treated with a regimen of 0.1% mometasone furoate cream applications to the affected areas once daily for 4 weeks and then twice weekly for 8 weeks. After 12 weeks of treatment, the subjects were asked to rate the changes in their symptoms and were reevaluated by the same examiner for the gross appearance of the lesions. In every patient the before/after treatment total severity scores were compared using Wilcoxon's signed-rank test for statistical significance.

RESULTS

With mometasone furoate all the patients had a significant improvement (P < .001) in the gross aspects of the disease and a very dramatic decrease in symptoms (P < .001), with nearly all the subjects having complete symptomatic remission. Compliance was excellent, and no side effects were observed.

CONCLUSION

The improved risk/benefit ratio of mometasone furoate may minimize the possible long-term side effects expected when using a very potent topical steroid. Therefore, momentasone furoate cream may be an alternative to clobetasol propionate for treatment of vulvar LS, with similar efficacy but higher levels of safety and tolerability.

Authors+Show Affiliations

Departments of Obstetrics and Gynecology, of Dermatology and of Pathology, University of Florence, Careggi, Viale Morgagni 85, 50100 Florence, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

12856516

Citation

Cattaneo, Antonio, et al. "Topical Mometasone Furoate for Vulvar Lichen Sclerosus." The Journal of Reproductive Medicine, vol. 48, no. 6, 2003, pp. 444-8.
Cattaneo A, De Magnis A, Botti E, et al. Topical mometasone furoate for vulvar lichen sclerosus. J Reprod Med. 2003;48(6):444-8.
Cattaneo, A., De Magnis, A., Botti, E., Sonni, L., Carli, P., & Taddei, G. L. (2003). Topical mometasone furoate for vulvar lichen sclerosus. The Journal of Reproductive Medicine, 48(6), 444-8.
Cattaneo A, et al. Topical Mometasone Furoate for Vulvar Lichen Sclerosus. J Reprod Med. 2003;48(6):444-8. PubMed PMID: 12856516.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Topical mometasone furoate for vulvar lichen sclerosus. AU - Cattaneo,Antonio, AU - De Magnis,Angelina, AU - Botti,Elena, AU - Sonni,Lorella, AU - Carli,Paolo, AU - Taddei,Gian Luigi, PY - 2003/7/15/pubmed PY - 2003/10/18/medline PY - 2003/7/15/entrez SP - 444 EP - 8 JF - The Journal of reproductive medicine JO - J Reprod Med VL - 48 IS - 6 N2 - OBJECTIVE: To assess the efficacy and safety of treating vulvar lichen sclerosus with mometasone furoate, a synthetic analogue of beclomethasone. STUDY DESIGN: Thirty-one consecutive patients with biopsy-proven vulvar lichen sclerosus (LS) seen at the Florence Vulvar Clinic were entered into the study. Each subject's symptoms and the gross appearance of the lesions were recorded using a severity score according to the authors' previous studies. The patients were treated with a regimen of 0.1% mometasone furoate cream applications to the affected areas once daily for 4 weeks and then twice weekly for 8 weeks. After 12 weeks of treatment, the subjects were asked to rate the changes in their symptoms and were reevaluated by the same examiner for the gross appearance of the lesions. In every patient the before/after treatment total severity scores were compared using Wilcoxon's signed-rank test for statistical significance. RESULTS: With mometasone furoate all the patients had a significant improvement (P < .001) in the gross aspects of the disease and a very dramatic decrease in symptoms (P < .001), with nearly all the subjects having complete symptomatic remission. Compliance was excellent, and no side effects were observed. CONCLUSION: The improved risk/benefit ratio of mometasone furoate may minimize the possible long-term side effects expected when using a very potent topical steroid. Therefore, momentasone furoate cream may be an alternative to clobetasol propionate for treatment of vulvar LS, with similar efficacy but higher levels of safety and tolerability. SN - 0024-7758 UR - https://www.unboundmedicine.com/medline/citation/12856516/Topical_mometasone_furoate_for_vulvar_lichen_sclerosus_ DB - PRIME DP - Unbound Medicine ER -