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Effect of Casearia esculenta root extract on blood glucose and plasma antioxidant status in streptozotocin diabetic rats.
Pol J Pharmacol. 2003 Jan-Feb; 55(1):43-9.PJ

Abstract

Our preliminary study shows that an oral administration of an aqueous extract of Casearia esculenta, an indigenous antidiabetic plant popularly used in South India for diabetes mellitus, lowers blood glucose level under normal and glucose load conditions, and in streptozotocin (STZ)-induced diabetes in rats. The study was further undertaken to evaluate the antioxidant potential of C. esculenta in STZ diabetic rats. Oral administration of C. esculenta root extract at doses of 200 and 300 mg/kg for 45 days resulted in significant reduction in plasma thiobarbituric acid reactive substances (TBARS), hydroperoxide and ceruloplasmin and a significant elevation in plasma reduced glutathione (GSH), ascorbic acid (vitamin C) and alpha-tocopherol (vitamin E). The study indicates that C. esculenta root extract at doses of 200 and 300 mg/kg restored all the antioxidant parameters to near normal value.

Authors+Show Affiliations

Division of Biochemistry, Rajah Muthiah Medical College and Hospital, Annamalai University, Annamalainagar-608 002, Tamilnadu, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12856825

Citation

Prakasam, Annamalai, et al. "Effect of Casearia Esculenta Root Extract On Blood Glucose and Plasma Antioxidant Status in Streptozotocin Diabetic Rats." Polish Journal of Pharmacology, vol. 55, no. 1, 2003, pp. 43-9.
Prakasam A, Sethupathy S, Pugalendi KV. Effect of Casearia esculenta root extract on blood glucose and plasma antioxidant status in streptozotocin diabetic rats. Pol J Pharmacol. 2003;55(1):43-9.
Prakasam, A., Sethupathy, S., & Pugalendi, K. V. (2003). Effect of Casearia esculenta root extract on blood glucose and plasma antioxidant status in streptozotocin diabetic rats. Polish Journal of Pharmacology, 55(1), 43-9.
Prakasam A, Sethupathy S, Pugalendi KV. Effect of Casearia Esculenta Root Extract On Blood Glucose and Plasma Antioxidant Status in Streptozotocin Diabetic Rats. Pol J Pharmacol. 2003 Jan-Feb;55(1):43-9. PubMed PMID: 12856825.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Casearia esculenta root extract on blood glucose and plasma antioxidant status in streptozotocin diabetic rats. AU - Prakasam,Annamalai, AU - Sethupathy,Subramaniam, AU - Pugalendi,Kodukkur V, PY - 2003/7/15/pubmed PY - 2004/2/28/medline PY - 2003/7/15/entrez SP - 43 EP - 9 JF - Polish journal of pharmacology JO - Pol J Pharmacol VL - 55 IS - 1 N2 - Our preliminary study shows that an oral administration of an aqueous extract of Casearia esculenta, an indigenous antidiabetic plant popularly used in South India for diabetes mellitus, lowers blood glucose level under normal and glucose load conditions, and in streptozotocin (STZ)-induced diabetes in rats. The study was further undertaken to evaluate the antioxidant potential of C. esculenta in STZ diabetic rats. Oral administration of C. esculenta root extract at doses of 200 and 300 mg/kg for 45 days resulted in significant reduction in plasma thiobarbituric acid reactive substances (TBARS), hydroperoxide and ceruloplasmin and a significant elevation in plasma reduced glutathione (GSH), ascorbic acid (vitamin C) and alpha-tocopherol (vitamin E). The study indicates that C. esculenta root extract at doses of 200 and 300 mg/kg restored all the antioxidant parameters to near normal value. SN - 1230-6002 UR - https://www.unboundmedicine.com/medline/citation/12856825/Effect_of_Casearia_esculenta_root_extract_on_blood_glucose_and_plasma_antioxidant_status_in_streptozotocin_diabetic_rats_ L2 - http://www.if-pan.krakow.pl/pjp/pdf/2003/1_43.pdf DB - PRIME DP - Unbound Medicine ER -