Tags

Type your tag names separated by a space and hit enter

Is serum leptin level regulated by thyroid functions, lipid metabolism and insulin resistance in polycystic ovary syndrome?
Gynecol Endocrinol 2003; 17(3):223-9GE

Abstract

Our aim was to determine whether serum leptin level is regulated by thyroid hormones, lipid metabolic products and insulin resistance status in women with polycystic ovary syndrome (PCOS). A prospective case-controlled study was carried out in Istanbul University, Cerrahpasa School of Medicine in 25 lean PCOS (L-PCOS) women, 19 obese PCOS (O-PCOS) women and 28 normal women. The diagnosis of PCOS was established according to the clinical, hormonal (elevated luteinizing hormone and serum androgens) and ultrasonographic findings. Fasting serum levels of thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), fasting glucose, insulin, total cholesterol (TC), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), very low-density lipoprotein-cholesterol (VLDL-C) and leptin were measured and compared in the three groups and the correlations between serum levels of leptin and other parameters were evaluated. Serum leptin levels were higher in the O-PCOS group, while its level was comparable between the L-PCOS and control groups. Serum levels of FT4 were significantly lower in both L-PCOS and O-PCOS groups than the control group. Women in both L-PCOS and O-PCOS groups were found to be significantly hyperinsulinemic and insulin resistant. Serum levels of TC, VLDL-C and TG were significantly higher in the O-PCOS group, while serum HDL-C level was lower. There was a poor correlation between serum leptin, and FT4, TC, TG, HDL-C and VLDL-C levels. A significant correlation was observed between serum leptin levels and both BMI and insulin resistance status in PCOS. We believe that, although thyroid hormones and lipid metabolic products do not seem to participate in the regulation of serum leptin levels, BMI and insulin resistance status may have a key role in women with PCOS.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Cerrahpasa School of Medicine, Istanbul University, Kasaneler Sk. Nigarhanim Apt. No:28/11, Erenkoy 81070, Istanbul, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12857430

Citation

Erel, C T., et al. "Is Serum Leptin Level Regulated By Thyroid Functions, Lipid Metabolism and Insulin Resistance in Polycystic Ovary Syndrome?" Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 17, no. 3, 2003, pp. 223-9.
Erel CT, Senturk LM, Kaleli S, et al. Is serum leptin level regulated by thyroid functions, lipid metabolism and insulin resistance in polycystic ovary syndrome? Gynecol Endocrinol. 2003;17(3):223-9.
Erel, C. T., Senturk, L. M., Kaleli, S., Gezer, A., Baysal, B., & Tasan, E. (2003). Is serum leptin level regulated by thyroid functions, lipid metabolism and insulin resistance in polycystic ovary syndrome? Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 17(3), pp. 223-9.
Erel CT, et al. Is Serum Leptin Level Regulated By Thyroid Functions, Lipid Metabolism and Insulin Resistance in Polycystic Ovary Syndrome. Gynecol Endocrinol. 2003;17(3):223-9. PubMed PMID: 12857430.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is serum leptin level regulated by thyroid functions, lipid metabolism and insulin resistance in polycystic ovary syndrome? AU - Erel,C T, AU - Senturk,L M, AU - Kaleli,S, AU - Gezer,A, AU - Baysal,B, AU - Tasan,E, PY - 2003/7/15/pubmed PY - 2003/10/18/medline PY - 2003/7/15/entrez SP - 223 EP - 9 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 17 IS - 3 N2 - Our aim was to determine whether serum leptin level is regulated by thyroid hormones, lipid metabolic products and insulin resistance status in women with polycystic ovary syndrome (PCOS). A prospective case-controlled study was carried out in Istanbul University, Cerrahpasa School of Medicine in 25 lean PCOS (L-PCOS) women, 19 obese PCOS (O-PCOS) women and 28 normal women. The diagnosis of PCOS was established according to the clinical, hormonal (elevated luteinizing hormone and serum androgens) and ultrasonographic findings. Fasting serum levels of thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), fasting glucose, insulin, total cholesterol (TC), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), very low-density lipoprotein-cholesterol (VLDL-C) and leptin were measured and compared in the three groups and the correlations between serum levels of leptin and other parameters were evaluated. Serum leptin levels were higher in the O-PCOS group, while its level was comparable between the L-PCOS and control groups. Serum levels of FT4 were significantly lower in both L-PCOS and O-PCOS groups than the control group. Women in both L-PCOS and O-PCOS groups were found to be significantly hyperinsulinemic and insulin resistant. Serum levels of TC, VLDL-C and TG were significantly higher in the O-PCOS group, while serum HDL-C level was lower. There was a poor correlation between serum leptin, and FT4, TC, TG, HDL-C and VLDL-C levels. A significant correlation was observed between serum leptin levels and both BMI and insulin resistance status in PCOS. We believe that, although thyroid hormones and lipid metabolic products do not seem to participate in the regulation of serum leptin levels, BMI and insulin resistance status may have a key role in women with PCOS. SN - 0951-3590 UR - https://www.unboundmedicine.com/medline/citation/12857430/Is_serum_leptin_level_regulated_by_thyroid_functions_lipid_metabolism_and_insulin_resistance_in_polycystic_ovary_syndrome L2 - https://medlineplus.gov/polycysticovarysyndrome.html DB - PRIME DP - Unbound Medicine ER -