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Optimization of the chiral resolution of baclofen by capillary electrophoresis using beta-cyclodextrin as the chiral selector.
Electrophoresis. 2003 Jun; 24(12-13):2064-2069.E

Abstract

The chiral resolution of baclofen was achieved by capillary electrophoresis using a fused-silica capillary (60 cm x 75 microm ID). The background electrolyte (BGE) was phosphate buffer (pH 7.0, 50 mM)-acetonitrile (95:5 v/v) containing 10 mM beta-cyclodextrin. The applied voltage was 15 kV. The values of alpha and R(s) were 1.06 and 1.00, respectively. The electrophoretic conditions were optimized varying the pH and the ionic strength of the BGE, concentrations of beta-cyclodextrin and acetonitrile and the applied voltage.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Ali I
Pharmaceutical Analysis Laboratory, Biological and Medical Research Department (MBC-03), King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Aboul-Enein HY
Pharmaceutical Analysis Laboratory, Biological and Medical Research Department (MBC-03), King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

MeSH

BaclofenCyclodextrinsElectrophoresis, CapillaryHydrogen-Ion ConcentrationOsmolar ConcentrationStereoisomerismbeta-Cyclodextrins

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12858376

Citation

Ali, Imran, and Hassan Y. Aboul-Enein. "Optimization of the Chiral Resolution of Baclofen By Capillary Electrophoresis Using Beta-cyclodextrin as the Chiral Selector." Electrophoresis, vol. 24, no. 12-13, 2003, pp. 2064-2069.
Ali I, Aboul-Enein HY. Optimization of the chiral resolution of baclofen by capillary electrophoresis using beta-cyclodextrin as the chiral selector. Electrophoresis. 2003;24(12-13):2064-2069.
Ali, I., & Aboul-Enein, H. Y. (2003). Optimization of the chiral resolution of baclofen by capillary electrophoresis using beta-cyclodextrin as the chiral selector. Electrophoresis, 24(12-13), 2064-2069. https://doi.org/10.1002/elps.200305439
Ali I, Aboul-Enein HY. Optimization of the Chiral Resolution of Baclofen By Capillary Electrophoresis Using Beta-cyclodextrin as the Chiral Selector. Electrophoresis. 2003;24(12-13):2064-2069. PubMed PMID: 12858376.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optimization of the chiral resolution of baclofen by capillary electrophoresis using beta-cyclodextrin as the chiral selector. AU - Ali,Imran, AU - Aboul-Enein,Hassan Y, PY - 2003/7/15/pubmed PY - 2004/4/8/medline PY - 2003/7/15/entrez SP - 2064 EP - 2069 JF - Electrophoresis JO - Electrophoresis VL - 24 IS - 12-13 N2 - The chiral resolution of baclofen was achieved by capillary electrophoresis using a fused-silica capillary (60 cm x 75 microm ID). The background electrolyte (BGE) was phosphate buffer (pH 7.0, 50 mM)-acetonitrile (95:5 v/v) containing 10 mM beta-cyclodextrin. The applied voltage was 15 kV. The values of alpha and R(s) were 1.06 and 1.00, respectively. The electrophoretic conditions were optimized varying the pH and the ionic strength of the BGE, concentrations of beta-cyclodextrin and acetonitrile and the applied voltage. SN - 0173-0835 UR - https://www.unboundmedicine.com/medline/citation/12858376/Optimization_of_the_chiral_resolution_of_baclofen_by_capillary_electrophoresis_using_beta_cyclodextrin_as_the_chiral_selector_ DB - PRIME DP - Unbound Medicine ER -