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Increase in neuronal nitric oxide synthase content of the gastroduodenal tract of diabetic rats.
Cell Mol Life Sci 2003; 60(6):1172-9CM

Abstract

This study examined the changes occurring in the pattern of distribution and expression of neuronal nitric oxide synthase (nNOS)-positive nerves in the gastroduodenal tract of streptozotocin-induced diabetic rats. The ganglion cells of the myenteric plexus of the gastric antrum of normal rats contain nNOS. We also observed nNOS-positive neurons and fibres in the myenteric plexus of the duodenum of normal rats. After the onset of diabetes, the number and intensity of staining of nNOS-positive nerve profiles in the gastric antrum and duodenum did not change significantly. However, Western blotting showed a significant increase in the expression of nNOS after the onset of diabetes. In conclusion, diabetes of 4 and 32 weeks duration induced an increase in the tissue content of nNOS in the gastroduodenum of rat. The increase in the level of nNOS in the gastroduodenum of diabetic rats may explain why impaired gastric emptying is common in patients with diabetes.

Authors+Show Affiliations

Department of Human Anatomy, Faculty of Medicine & Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates. eadeghate@uaeu.ac.aeNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12861383

Citation

Adeghate, E, et al. "Increase in Neuronal Nitric Oxide Synthase Content of the Gastroduodenal Tract of Diabetic Rats." Cellular and Molecular Life Sciences : CMLS, vol. 60, no. 6, 2003, pp. 1172-9.
Adeghate E, al-Ramadi B, Saleh AM, et al. Increase in neuronal nitric oxide synthase content of the gastroduodenal tract of diabetic rats. Cell Mol Life Sci. 2003;60(6):1172-9.
Adeghate, E., al-Ramadi, B., Saleh, A. M., Vijayarasathy, C., Ponery, A. S., Arafat, K., ... El-Sharkawy, T. (2003). Increase in neuronal nitric oxide synthase content of the gastroduodenal tract of diabetic rats. Cellular and Molecular Life Sciences : CMLS, 60(6), pp. 1172-9.
Adeghate E, et al. Increase in Neuronal Nitric Oxide Synthase Content of the Gastroduodenal Tract of Diabetic Rats. Cell Mol Life Sci. 2003;60(6):1172-9. PubMed PMID: 12861383.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increase in neuronal nitric oxide synthase content of the gastroduodenal tract of diabetic rats. AU - Adeghate,E, AU - al-Ramadi,B, AU - Saleh,A M, AU - Vijayarasathy,C, AU - Ponery,A S, AU - Arafat,K, AU - Howarth,F C, AU - El-Sharkawy,T, PY - 2003/7/16/pubmed PY - 2003/8/6/medline PY - 2003/7/16/entrez SP - 1172 EP - 9 JF - Cellular and molecular life sciences : CMLS JO - Cell. Mol. Life Sci. VL - 60 IS - 6 N2 - This study examined the changes occurring in the pattern of distribution and expression of neuronal nitric oxide synthase (nNOS)-positive nerves in the gastroduodenal tract of streptozotocin-induced diabetic rats. The ganglion cells of the myenteric plexus of the gastric antrum of normal rats contain nNOS. We also observed nNOS-positive neurons and fibres in the myenteric plexus of the duodenum of normal rats. After the onset of diabetes, the number and intensity of staining of nNOS-positive nerve profiles in the gastric antrum and duodenum did not change significantly. However, Western blotting showed a significant increase in the expression of nNOS after the onset of diabetes. In conclusion, diabetes of 4 and 32 weeks duration induced an increase in the tissue content of nNOS in the gastroduodenum of rat. The increase in the level of nNOS in the gastroduodenum of diabetic rats may explain why impaired gastric emptying is common in patients with diabetes. SN - 1420-682X UR - https://www.unboundmedicine.com/medline/citation/12861383/Increase_in_neuronal_nitric_oxide_synthase_content_of_the_gastroduodenal_tract_of_diabetic_rats_ L2 - https://dx.doi.org/10.1007/s00018-003-2298-2 DB - PRIME DP - Unbound Medicine ER -